Overactive bladder: the urinary microbiota at fault

Vignette

Overactive bladder may be induced or made more likely by anomalies in the urinary microbiota

 

This is what an English team suggested by clearly showing the differences in bladder microbiota composition in women affected with this syndrome when compared with healthy women. To compare these microbiotas, researchers took urine samples and analyzed bacteria from 60 women visiting the doctor for that reason and 35 control subjects. They obtained a wide variety of bacterial genera (up to 95 different ones), although each woman had on average five different strains. The most frequently encountered were Staphylococcus, Streptococcus, Corynebacterium and Lactobacillus. Moreover, the authors noted significant differences between the two groups. The women with overactive bladder had Lactobacillus demonstrably less often than control subjects (20% vs. 43%). Conversely, Proteus was found more frequently (23% vs. 3%). Is there a correlation between bladder bacterial profiles and both the nature of symptoms, and the course of the disease? These studies may lead to the development of therapeutic tools based on the modification of the microbiota

 

Sources:
Curtiss N et al. A case controlled study examining the bladder microbiome in women with Overactive Bladder (OAB) and healthy controls. European Journal of Obstetrics & Gynecology and Reproductive Biology 214 (2017) 31–35