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Mutational signature of e. Coli in colorectal cancer

A team has recently proved how certain genotoxic strains of Escherichia coli damage DNA, leading to an increased risk of colorectal cancer. In the future, will it be possible to curb this process?   While various species of the gut microbiota are linked to colorectal cancer (CRC), a direc...
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What if manipulating the microbiota could improve the response to immunotherapy?

Gut microbiota may modulate responses to immunotherapy. Although it is too early to propose a scientifically validated cocktail of probiotics, the use of antibiotics during therapy should be better justified.   More effective and less toxic than chemotherapy, CAR-T cell immunotherapy is t...
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Colorectal cancer: from dysbiosis to DNA alteration

The role of dysbiosis in the pathogenesis of colorectal cancer is revealed: it seems to promote colon carcinogenesis via DNA alterations in the host. This could mean that a non-invasive blood test could be used for detection purposes.   Colorectal cancer (CRC) is one of the most common ma...
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