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Colorectal cancer: from dysbiosis to DNA alteration

The role of dysbiosis in the pathogenesis of colorectal cancer is revealed: it seems to promote colon carcinogenesis via DNA alterations in the host. This could mean that a non-invasive blood test could be used for detection purposes.   Colorectal cancer (CRC) is one of the most common ma...
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Cancer immunotherapy: no prior antibiotic treatment

Gut dysbiosis caused by the prior use of broad-spectrum antibiotics could impact the efficacy of cancer immunotherapy, in turn leading to a decrease in overall patient survival.   Immune checkpoint inhibitor (ICI) therapy is a form of immunotherapy that provides a new therapeutic option a...
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Key role of tumor bacteria in pancreatic cancer

The composition of pancreatic tumor microbiome, which is impacted by the gut microbiota, could modulate the patient’s immune response and the growth of adenocarcinoma. Could this discovery rekindle the interest in fecal transplants?   Pancreatic ductal adenocarcinoma (PDAC) is a dreaded c...
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