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Could the metabolome be used to better diagnose c. Difficile infections?

Two large families of metabolites (the first are derived from leucine and the second from bile acids) could have the potential to discriminate between a C. difficile infection and an asymptomatic C. difficile colonization.   Clostridioides difficile* infection (CDI) affects about 450,000 ...

Fecal transplant and recurrent Clostridium difficile infections: bacteriophages are necessary in donors

According to a Canadian study, the diversity and relative abundance in donors’ bacteriophages seem to have an impact on the success of fecal transplants in patients with recurrent Clostridium difficile infections.   Despite the positive results obtained with fecal microbiota transplants (...

Success of fecal transplant is conditioned by intestinal mycobiota

Proliferation of an opportunistic yeast in the intestines could be the cause of fecal transplant failure in the treatment of Clostridium difficile infections. Outcome might be improved by reversing fungal dysbiosis.   In ten years, fecal microbiota transplants (FMT) have led to recovery r...
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Antibiotic-associated diarrhea

Antibiotics, by disturbing the intestinal microbiota, can cause more-or-less severe diarrhea.

Fecal transplants

Fecal transplant consists of implanting a healthy microbiota through natural passages into a patient to restore their microbial ecosystem. Fecal transplant is an intervention that has been known and practiced for a long time, since the first signs of its use appear in China in the 4th century. Ho...
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