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The microbiota as a barrier against rotavirus

A segmented filamentous bacterium found in the microbiota of some mice gives them the ability to resist rotavirus-induced infections. A more frequent renewal of the intestinal epithelium could explain this barrier effect.   When a virus enters the digestive tract and is about to infect in...
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Could the metabolome be used to better diagnose c. Difficile infections?

Two large families of metabolites (the first are derived from leucine and the second from bile acids) could have the potential to discriminate between a C. difficile infection and an asymptomatic C. difficile colonization.   Clostridioides difficile* infection (CDI) affects about 450,000 ...
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The intestinal microbiota could increase rotavirus vaccine effectiveness

Preliminary results suggest that targeted changes in the intestinal microbiota could improve rotavirus vaccine immunogenicity, which is decreasing in developing countries where prevalence of this disease is highest.   Rotavirus vaccination, although effective in Western countries, is much...
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IBD

Chronic inflammatory bowel diseases (IBDs), like Crohn’s disease and ulcerative colitis, are correlated with an imbalance in the microbiota.
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Infectious diarrhea

The intestinal equilibrium is significantly affected in cases of infectious diarrhea. Studying the microbial ecosystem over the course of the infection has resulted in notable progress in the treatment of this disorder.
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