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The microbiota as a barrier against rotavirus

A segmented filamentous bacterium found in the microbiota of some mice gives them the ability to resist rotavirus-induced infections. A more frequent renewal of the intestinal epithelium could explain this barrier effect.   When a virus enters the digestive tract and is about to infect in...
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Could the metabolome be used to better diagnose c. Difficile infections?

Two large families of metabolites (the first are derived from leucine and the second from bile acids) could have the potential to discriminate between a C. difficile infection and an asymptomatic C. difficile colonization.   Clostridioides difficile* infection (CDI) affects about 450,000 ...
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The intestinal microbiota could increase rotavirus vaccine effectiveness

Preliminary results suggest that targeted changes in the intestinal microbiota could improve rotavirus vaccine immunogenicity, which is decreasing in developing countries where prevalence of this disease is highest.   Rotavirus vaccination, although effective in Western countries, is much...
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Fecal transplants

Fecal transplant consists of implanting a healthy microbiota through natural passages into a patient to restore their microbial ecosystem. Fecal transplant is an intervention that has been known and practiced for a long time, since the first signs of its use appear in China in the 4th century. Ho...
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