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Bacteria that deliver treatment to the heart of the tumor

Release molecules directly in the heart of the tumor to assist the immune response and facilitate regression: this is the challenge taken up by probiotic bacteria specially designed to reach their target, multiply and release their cellular content.   While immune checkpoint inhibitors (I...
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Cancer immunotherapy: no prior antibiotic treatment

Gut dysbiosis caused by the prior use of broad-spectrum antibiotics could impact the efficacy of cancer immunotherapy, in turn leading to a decrease in overall patient survival.   Immune checkpoint inhibitor (ICI) therapy is a form of immunotherapy that provides a new therapeutic option a...
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Fecal transplant: a solution for ici-induced colitis?

A preliminary trial with two patients showed that an allogeneic fecal microbiota transplant could help resorb refractory immune checkpoint inhibitor-associated colitis. This avenue remains to be explored as the field of immuno-oncology is blossoming.   The latest therapeutic advances in o...
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