Skip to main content
About the Institute
  • English
  • Français
  • Español
  • Russian
  • Portuguese

Breadcrumb

  1. Home
  2. Gastroenterology
  3. Fecal transplant and recurrent Clostridium difficile infections: bacteriophages are necessary in donors
  • Our publications
    • News
    • Microbiota Mag
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • Partnerships
    • Press room
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
    • Xpeer App
  • Useful documents
    • Infographics
    • IBS Diagnosis Check List
    About the Institute

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

Lay public section

Find here your dedicated section
Gastroenterology
Gynecology
Pediatrics
Dermatology

Breadcrumb

  1. Home
  2. Gastroenterology
  3. Fecal transplant and recurrent Clostridium difficile infections: bacteriophages are necessary in donors
Gastroenterology

Fecal transplant and recurrent Clostridium difficile infections: bacteriophages are necessary in donors

C difficile
Gastroenterology

According to a Canadian study, the diversity and relative abundance in donors’ bacteriophages seem to have an impact on the success of fecal transplants in patients with recurrent Clostridium difficile infections.

Gastroenterology
Gynecology
Pediatrics
Dermatology
  • Our publications
    • News
    • Microbiota Mag
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • Partnerships
    • Press room
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
    • Xpeer App
  • Useful documents
    • Infographics
    • IBS Diagnosis Check List
    About the Institute

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

Lay public section

Find here your dedicated section

Sources

This article is based on scientific information

Sharing is caring

Your colleagues might be interested in this topic. Why not share it?

  • Facebook
  • Twitter
  • LinkedIn
  • Mail
Actu PRO : Greffe fécale et infection récidivante à Clostridium difficile : des bactériophages essentiels chez les donneurs

About this article

Created 04 June 2019
Updated 06 October 2021

 

Despite the positive results obtained with fecal microbiota transplants (FMT) as a first-line treatment for recurrent Clostridium difficile infections (rCDI), 8 to 50% of patients relapse. Recent works have shown the potential influence of bacteriophages–a virus that infects bacteria within the gut microbiota–on the success rate of fecal transplants. A Canadian team thus studied the impact of bacteriophage populations in donors and patients with rCDI treated with FMT via colonoscopy.

Impact of FMT on bacteriophages

Unsurprisingly, all 19 recipients from this trial had a less diversified gut microbiota than the 7 donors. The diversity of their bacteriophages was greater than that of donors and of the 96 control subjects. This was potentially due the administration of vancomycin in the 24 hours before the transplant, which could trigger the induction of phages. The FMT, which was effective from the first administration in 12 patients, led to a reduction of this increased diversity. For the 7 patients who received a second FMT, bacteriophage diversity was only reduced on the second attempt.

Importance of donors’ profile

On the bacterial front, recipients’ profile became more similar to the donors’ after a successful transplant: increased levels of Bacteroidetes and Firmicutes, decreased levels of Proteobacteria, which were prevalent until then (mainly species from the Klebsiella and Escherichia genera). Nevertheless, no difference was observed between patients who had a positive response after the first transplant and those who did not. On the contrary, donors’ bacteriophages seem to be correlated to the successful or failed outcome of the transplant: greater diversity as well as decreased relative abundance were associated to a successful FMT. But before using donors’ bacteriophage composition as a prognostic factor for FMT in the treatment of rCDI, the researchers call for revised research methods into this facet of the gut flora which is still largely unknown. They believe these results are probably only the “tip of the iceberg”.

 

Sources

Park H, Laffin MR, Jovel J et al. The success of fecal microbial transplantation in Clostridium difficile infection correlates with bacteriophage relative abundance in the donor: a retrospective cohort study, Gut Microbes. 2019;10(6):676-687

Old sources

 

 

Tags
Fecal transplant AAD Dysbiosis CDI Clostridium difficile Bacteriophage

en_view en_sources

    Created 04 June 2019
    Updated 06 October 2021

    About this article

    To know more about this topic.

    Main topic

    C difficile

    Medical practice

    Gastroenterology

    Content type

    News
    Gastroenterology

    Everything you need to know about Irritable Bowel Syndrome (IBS)

    Accrediting training, infographics, expert’s video, thematic folder, news… Biocodex Microbiota Institute pr...

    Find out more

    Your IBS Diagnosis Check List

    How many patients suffering from gut disorder do you see per week? How many are diagnosed with Irritable Bo...

    Find out more

    Human milk nutrient fortifiers alter the developing gastrointestinal microbiota of very-low-birth-weight infants

    Commented article - Children's section By Pr. Emmanuel M...

    Find out more

    Impact of beer and non alcoholic consumption on the gut microbiota

    By Pr. Bernd SchnablDivision of Gastroenterology, San Diego Digestive Diseases Research Center (SDDRC), UC ...

    Find out more

    Gut Microbiota #17

    By Pr. Satu PekkalaAcademy of Finland Research Fellow, Faculty of Sport and Health Sciences, University of ...

    Find out more

    Gut Microbiota # 16

    By Pr. Satu PekkalaAcademy of Finland Research Fellow, Faculty of Sport and Health Sciences, University of ...

    Find out more

    Highlights from the UEGW

    By Dr. Lucas WautersGastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium

    Find out more

    The Gut-Brain axis

    By Pr. Sarkis K. Mazmanian, John W. Bostick, Nadia SuryawinataBiology and Biological Engineering, Californi...

    Find out more

    Continue reading

    News
    SII, microbiote intestinal et dépression : un triptyque pour mieux comprendre la maladie
    27.07.2022

    IBS, gut microbiota and depression: a trio shedding light on the disease

    Read the article
    Actu PRO : Cancer du poumon : le microbiote intestinal signerait un stade précoce
    02.07.2020

    Gut microbiota could be an indicator of early-stage lung cancer

    Read the article
    Obesity: Is a bacterial fatty acid involved?
    15.05.2023

    Obesity: Is a bacterial fatty acid involved?

    Read the article
    Photo: Endométriose : une clé de sa progression au sein du microbiote intestinal
    09.05.2023

    Endometriosis: A key to its progression in the gut microbiota?

    Read the article
    16.11.2022

    Alcohol use disorders: in microbiota veritas?

    Read the article
    Photo: Atténuer la dénutrition avec des biotiques ?
    26.04.2023

    Mitigating malnutrition with biotics?

    Read the article
    25.04.2023

    F. prausnitzii : a biomarker of chronic fatigue syndrome

    Read the article
    Photo: Quand les interactions sociales façonnent nos microbiotes
    05.04.2023

    The role of social interactions in shaping our microbiota

    Read the article
    What's worth reading about microbiota
    Follow us on Twitter
    Read our thematic folder
    The Janus face of Antibiotics: Life Savers & Microbiota Disrupters
    Microbiota 17 EN
    Check out our latest magazine
    The first 1000 days of life
    • Our publications
      • News
      • Microbiota Mag
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographics
      • IBS Diagnosis Check List
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube

    Lay public section

    Find here your dedicated section
    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology
    • English
    • Français
    • Español
    • Russian
    • Portuguese

    Browse the site

    • Our publications
      • News
      • Microbiota Mag
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographics
      • IBS Diagnosis Check List
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

    Lay public section

    Find here your dedicated section

    Redirection

    You are about to be redirected and leave our website

    • Be redirected
    • Stay on the Biocodex Microbiota Institute's website

    Stay with us !

    Join the Microbiota Community of HCPs and researchers and receive “Microbiota Digest” and "Microbiota Mag" to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    Explore

    Obesity: Is a bacterial fatty acid involved?
    15.05.2023

    Obesity: Is a bacterial fatty acid involved?

    Read the article
    Photo: Endométriose : une clé de sa progression au sein du microbiote intestinal
    09.05.2023

    Endometriosis: A key to its progression in the gut microbiota?

    Read the article
    Photo: Atténuer la dénutrition avec des biotiques ?
    26.04.2023

    Mitigating malnutrition with biotics?

    Read the article

    Stay updated

    Join the Microbiota Community of HCPs and researchers and receive “Microbiota Digest” and "Microbiota Mag" to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    • Our publications
      • News
      • Microbiota Mag
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographics
      • IBS Diagnosis Check List
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology

    Lay public section

    Find here your dedicated section

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

    © 2022 Biocodex. All rights reserved.

    • Cookies Policy
    • Data protection policy
    • GTU
    • Sitemap
    • Cookies settings
    Biocodex logo