Skip to main content
  • English
  • Français
  • Español
  • Russian
  • Portuguese

Breadcrumb

  1. Home
  2. Pediatrics
  3. The microbiota as a barrier against rotavirus
  • Our publications
    • News
    • Microbiota Mag
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • Partnerships
    • Press room
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
    • Xpeer App
  • Useful documents
    • Infographic
    About the Institute

    Join the microbiota community

    • Facebook
    • Twitter
    • YouTube

Lay public section

Find here your dedicated section
Gastroenterology
Gynecology
Pediatrics
Dermatology

Breadcrumb

  1. Home
  2. Pediatrics
  3. The microbiota as a barrier against rotavirus
Pediatrics

The microbiota as a barrier against rotavirus

Diarrhea
Pediatrics Gastroenterology

A segmented filamentous bacterium found in the microbiota of some mice gives them the ability to resist rotavirus-induced infections. A more frequent renewal of the intestinal epithelium could explain this barrier effect.

Gastroenterology
Gynecology
Pediatrics
Dermatology
  • Our publications
    • News
    • Microbiota Mag
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • Partnerships
    • Press room
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
    • Xpeer App
  • Useful documents
    • Infographic
    About the Institute

    Join the microbiota community

    • Facebook
    • Twitter
    • YouTube

Lay public section

Find here your dedicated section

Sources

This article is based on scientific information

Sharing is caring

Your colleagues might be interested in this topic. Why not share it?

  • Facebook
  • Twitter
  • Mail
Photo : The microbiota as a barrier against rotavirus

About this article

Created 28 January 2020
Updated 30 March 2022

 

When a virus enters the digestive tract and is about to infect intestinal cells, it is not alone: billions of bacteria from the microbiota are also there and can modulate its infectious potential. Scientists arrived at this conclusion accidentally while working on Rag1-KO mice, a model of immunodeficient mice with chronic rotavirus infection (RV).

The microbiota as a barrier against rotavirus

These researchers non-intentionally observed the birth of a line of RV-resistant mice, which they called (sidenote: GSU stands for Georgia State University, where these mice were born ) . They then tried to understand the origin of this resistant phenotype. When Rag1-KO mice were fed the feces of GSU mice, they became resistant to RV, thus proving the role of the microbiota of GSU mice.

A segmented filamentous bacterium is involved

A series of discriminating treatments (heat, filtrations, several antimicrobial agents) complemented by an analysis of the microbiome of GSU mice indicated the specific presence of Candidatus arthromitus species, which is a (sidenote: Bacteria from the Clostridiales family, that colonize the gut of many species )  (SFB). This presence was confirmed through electron microscopy at the ileum level. In vitro, the SFB strain had the same ability as GSU mice feces to reduce the infection of epithelial cells by rotavirus. In vivo and isolated from the microbiota, it still provided, by itself, a protection against RV to immunosuppressed germ-free mice, and reduced the incidence of diarrhea in newborn non-immunodeficient mice, thus proving its own protective effect.

A new non-immune mechanism

Contrary to the researchers’ initial hypothesis, no known immune mechanism mediating the resistance to RV was involved (neither IL-22/IL-17 nor interferon λ). Several non-immune pathways could coexist: SFB could degrade a surface compound of RV and prevent it from interacting with the epithelium. But the main underlying mechanism seems to be located on the host side: the renewal of villi epithelial cells could be accelerated under the influence of SFB, thus causing the quick expulsion of cells potentially infected by RV. The microbiota could thus become a key pool to develop new strategies against viral infections.

Sources

Zhenda Shi, Jun Zou, Zhan Zhang, et al. Segmented Filamentous Bacteria Prevent and Cure Rotavirus Infection. Cell. 2019 Oct 17;179(3):644-658.e13.

Tags
Immunity Rotavirus Gastroenteritis Diarrhea Immune system Infection

en_view en_sources

    Created 28 January 2020
    Updated 30 March 2022

    About this article

    To know more about this topic.

    Main topic

    Diarrhea

    Medical practice

    Pediatrics Gastroenterology

    Content type

    News

    Continue reading

    News
    26.04.2022

    Severe obesity: the vicious circle of biotin metabolism

    Read the article
    22.04.2022

    SCFAs: new intestinal markers of Parkinson’s disease?

    Read the article

    New perspectives in autism: the role of microbiota in social communication

    Overview By Dr. Vincent Trebossen Child and Adolescent P...

    Find out more

    Infographics to share with your patients!

    Download original graphic material to explain to your patients the role of the microbiota in their daily he...

    Find out more
    15.04.2022

    Multiple sclerosis and microbiota: does meat consumption play a role?

    Read the article

    Association between fungal dysbiosis and environment

    The fungal portion of the gut microbiota (or mycobiota) has been much less studied than the bacterial porti...

    Find out more
    08.04.2022

    Inflammatory Bowel Disease (IBD): do microplastics condition severity?

    Read the article
    04.04.2022

    The microbiota, a significant factor in smoking cessation

    Read the article
    What's worth reading about microbiota
    Follow us on Twitter
    Read our thematic folder
    The Janus face of Antibiotics: Life Savers & Microbiota Disrupters
    NL13_cover
    Check out latest newsletter
    IBS, Microbiota & Covid-19
    • Our publications
      • News
      • Microbiota Mag
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographic
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • YouTube

    Lay public section

    Find here your dedicated section
    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology
    • English
    • Français
    • Español
    • Russian
    • Portuguese

    Browse the site

    • Our publications
      • News
      • Microbiota Mag
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographic
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • YouTube

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology

    Join the microbiota community

    • Facebook
    • Twitter
    • YouTube

    Lay public section

    Find here your dedicated section

    en_redirection

    en_you_are_about_to_leave

    • en_be_redirected
    • en_stay_on_biocodex

    Stay with us !

    Join the Microbiota Community of HCPs and researchers and receive once a month the “Microbiota Digest” to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    Explore

    04.05.2022

    Miscarriage: Is vaginal dysbiosis a suspect?

    Read the article
    26.04.2022

    Severe obesity: the vicious circle of biotin metabolism

    Read the article
    22.04.2022

    SCFAs: new intestinal markers of Parkinson’s disease?

    Read the article

    Stay updated

    Join the Microbiota Community of HCPs and researchers and receive once a month the “Microbiota Digest” to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    • Our publications
      • News
      • Microbiota Mag
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographic
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • YouTube

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology

    Lay public section

    Find here your dedicated section

    Join the microbiota community

    • Facebook
    • Twitter
    • YouTube

    © 2022 Biocodex. All rights reserved.

    • Cookies Policy
    • Data protection policy
    • GTU
    • Sitemap
    • Cookies settings
    Biocodex logo