Skip to main content
About the Institute
  • English
  • Français
  • Español
  • Russian
  • Portuguese

Breadcrumb

  1. Home
  2. Microbiota, breastfeeding and early puberty
  • Our publications
    • News
    • Microbiota Mag
    • Thematic pages
    • Experts' point of view
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • About us
    • International Microbiota Observatory
    • Press room
    • Partnerships
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
    • Xpeer App
  • Useful documents
    • Infographics
    • IBS Diagnosis Check List
    • Patients Stories

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

Lay public section

Find here your dedicated section
Gastroenterology
Gynecology
Pediatrics
Dermatology

Breadcrumb

  1. Home
  2. Microbiota, breastfeeding and early puberty

Microbiota, breastfeeding and early puberty

Breastfeeding
Pediatrics

Maternal high-fat diet during lactation disrupts the intestinal microbiota of young mice, increases the likelihood of early puberty in young females and generates insulin insensitivity. The sharing of microbiota, through cohabitation with the offspring of mothers fed on a regular diet, reverses this trend.

Gastroenterology
Gynecology
Pediatrics
Dermatology
  • Our publications
    • News
    • Microbiota Mag
    • Thematic pages
    • Experts' point of view
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • About us
    • International Microbiota Observatory
    • Press room
    • Partnerships
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
    • Xpeer App
  • Useful documents
    • Infographics
    • IBS Diagnosis Check List
    • Patients Stories

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

Lay public section

Find here your dedicated section

Sources

This article is based on scientific information

Sharing is caring

Your colleagues might be interested in this topic. Why not share it?

  • Facebook
  • Twitter
  • LinkedIn
  • Mail
Photo : Microbiota, breastfeeding and early puberty

About this article

Created 22 April 2020
Updated 30 March 2022

Each year, early puberty affects 20 out of every 10,000 girls worldwide, with childhood obesity increasing the risk of occurrence. Since 2010, greater attention has been paid to the effects of the intestinal microbiota on energy homeostasis and obesity. Although many factors may influence the gut microbiota (use of antibiotics, etc.), breastfeeding seems to play a primary role in its development. Researchers have therefore manipulated the diet of lactating female mice in order to assess the influence of diet on the risk of obesity and early puberty among their offspring. For three weeks from the birth of their pups, female mice were fed either a normal calorie diet (NCD) containing 12% fat or a high-fat diet (HFD) containing 60% fat. 21 days after birth, all the young mice were weaned, fed a normal calorie diet and randomly placed in cages alongside four young mice from NCD mothers, four young mice from HFD mothers or two young mice from NCD mothers and two young mice from HFD mothers. The goal was to measure the impact of this cohabitation and assess whether it reversed any effects of a maternal high-fat diet upon offspring.

Impact of maternal diet during breastfeeding

A high-fat diet for mothers during lactation influenced the development of their offspring’s microbiota. For example, there was an increase in the proportion of Streptococcaceae and Peptostreptococcaceae in the intestinal microbiota of the young mice. In addition, the offspring of HFD mothers had microbiota with significantly less richness. A maternal high-fat diet also resulted in childhood obesity, early puberty, irregular menstrual cycles and signs of impaired glucose metabolism in female offspring. However, early puberty was not observed in young males.

Effects of sharing microbiota

Since mice are coprophagous animals, they share their microbiota via the fecal-oral route. Following cohabitation with the offspring of NCD mothers, the offspring of HFD mothers saw the abundance of their microbiota increase, reversing the effects of the maternal high-fat diet. This also protected females against early puberty and insensitivity to insulin. However, no protective effect was observed on the weight or body fat of HFD offspring.

A new therapeutic approach for metabolic disorders?

According to the authors, breastfeeding plays a critical role in the development of a normal metabolic and reproductive function among offspring. Insulin resistance associated with a microbiota dysbiosis increases the likelihood of early puberty where this results from a high-fat maternal diet during breastfeeding. Consequently, microbiota may represent a new therapeutic target in the treatment of metabolic and reproductive disorders.

Sources

Wang M, Zhang Y, Miller D, Rehman NO, et al. Microbial reconstitution reverses early female puberty induced by maternal high-fat diet during lactation. Endocrinology. 2020 Feb 1;161(2):bqz041.

Tags
Puberty Maternal diet Breastfeeding Metabolic disease Insulin

en_view en_sources

    Created 22 April 2020
    Updated 30 March 2022

    About this article

    To know more about this topic.

    Main topic

    Breastfeeding

    Medical practice

    Pediatrics

    Content type

    News

    Continue reading

    News
    Microbiote déséquilibré à 1 an, allergie à 5 ans ?
    10.11.2023

    Does an unbalanced microbiota at age one lead to allergies at age five?

    Read the article

    Infographics to share with your patients!

    Download original graphic material to explain to your patients the role of the microbiota in their daily he...

    Find out more
    26.10.2023

    Can antibiotics promote the growth of harmful bacteria in the gut?

    Read the article

    How do you choose a probiotic for your patient?

    Faced with a plethora of products on the market, it's not always easy for health professionals to suggest a...

    Find out more
    Intestinal bacteria, illustration.
    24.08.2023

    Everything you need to know about probiotics

    Read the article
    Antibiotiques : le mycobiote des nourrissons sous influence
    16.08.2022

    The effect of antibiotics on infant mycobiota

    Read the article
    Actu PRO : Une antibiothérapie prophylactique péri-partum appauvrit le lait maternel en Bifidobacterium
    12.03.2019

    Peripartum prophylactic antibiotic therapy decreases bifidobacterium levels in breast milk

    Read the article
    24.11.2020

    Antibiotics and risk of IBD in adults

    Read the article
    What's worth reading about microbiota
    Follow us on X
    Read our thematic folder
    The Janus face of Antibiotics: Life Savers & Microbiota Disrupters
    Microbiota 17 EN
    Check out our latest magazine
    The first 1000 days of life
    • Our publications
      • News
      • Microbiota Mag
      • Thematic pages
      • Experts' point of view
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • About us
      • International Microbiota Observatory
      • Press room
      • Partnerships
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographics
      • IBS Diagnosis Check List
      • Patients Stories

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube

    Lay public section

    Find here your dedicated section
    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology
    • English
    • Français
    • Español
    • Russian
    • Portuguese

    Browse the site

    • Our publications
      • News
      • Microbiota Mag
      • Thematic pages
      • Experts' point of view
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • About us
      • International Microbiota Observatory
      • Press room
      • Partnerships
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographics
      • IBS Diagnosis Check List
      • Patients Stories

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

    Lay public section

    Find here your dedicated section

    Redirection

    You are about to be redirected and leave our website

    • Be redirected
    • Stay on the Biocodex Microbiota Institute's website

    Stay with us !

    Join the Microbiota Community of HCPs and researchers and receive “Microbiota Digest” and "Microbiota Mag" to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    Explore

    Antimicrobial resistance: Doctor, your role is essential! Patient, your behavior is key!

    In November, Biocodex and the Biocodex Microbiota Institu...

    Find out more
    22.11.2023

    Is vaginal microbiota transfer the new miracle for C-section babies?

    Read the article
    14.11.2023

    Immunotherapy coupled with FMT in patients with refractory melanoma: a Phase I trial

    Read the article

    Stay updated

    Join the Microbiota Community of HCPs and researchers and receive “Microbiota Digest” and "Microbiota Mag" to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    • Our publications
      • News
      • Microbiota Mag
      • Thematic pages
      • Experts' point of view
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • About us
      • International Microbiota Observatory
      • Press room
      • Partnerships
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographics
      • IBS Diagnosis Check List
      • Patients Stories

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology

    Lay public section

    Find here your dedicated section

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

    © 2022 Biocodex. All rights reserved.

    • Cookies Policy
    • Data protection policy
    • GTU
    • Sitemap
    • Cookies settings
    • Digital accessibility : partially compliant
    Biocodex logo