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  3. Vaginal Microbiota #12
Gynecology

Vaginal Microbiota #12

Pre-eclampsia

By Prof. Markku Voutilainen
Turku University Faculty of Medicine; Turku University Hospital, Department of Gastroenterology, Turku, Finland

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Coloured scanning electron micrograph (SEM) of Prevotella melaninogenica, formerly known as Bacteroides melaninogenicus, is Gram-negative, anaerobic, rod to coccobacillus shaped, prokaryote (bacterium)

Coloured scanning electron micrograph (SEM) of Prevotella melaninogenica, formerly known as Bacteroides melaninogenicus, is Gram-negative, anaerobic, rod to coccobacillus shaped, prokaryote (bacterium).

About this article

Author

Voutilainen Markku Prof Markku Voutilainen
Created 24 August 2021
Updated 12 August 2024

SEVERE PRE-ECLAMPSIA AND MICROBIOTA

Lin CY, Lin CY, Yeh YM, et al. Severe preeclampsia is associated with a higher relative abundance of Prevotella bivia in the vaginal microbiota. Sci Rep 2020; 10: 18249.

Severe preeclampsia (SPE) is a hypertensive disorder of pregnancy that can have serious consequences for both mother and child. It is characterized by hypertension and manifestations of a multisystem disorders. The role the vaginal microbiota may play in the pathogenesis of SPE remains unknown. The present study revealed that women with SPE had increased relative abundance of vaginal Prevotella bivia (Pb). Pb is an anaerobic gram-negative bacterial species that was previously associated with pelvic inflammatory disease and bacterial vaginosis. Previous studies have shown that obesity was a risk factor for SPE and that vaginal microbiota of obese women was characterized by increased diversity and predominance of Prevotella spp. In this study, the Body Mass Index (BMI) was the strongest SPE predictor and the authors suggest that the higher relative abundance of Pb in the vaginal microbial, which is tightly regulate by BMI, may be involved in the pathogenesis of SPE.

CERVICAL MUCUS ESSENTIAL FOR FEMALE REPRODUCTIVE HEALTH

Lacroix G, Gouyer V, Gottrand F, Desseyn JL. The cervicovaginal mucus barrier. Int J Mol Sci 2020; 21: 8266.

Cervical mucus (CM) is key for women health: it protects vaginal epithelium, helps to maintain fertility and fecundity. In this study, the authors assessed its role in both the physiological state and in bacterial vaginosis. Normal vaginal microbiota is characterized by Lactobacillus spp dominance. Undisturbed cooperation between vaginal microbiota, CM and host cells is necessary for vaginal health. This includes acidification by lactic acid, production of reactive oxygen species, interaction between mucins and cells, and diffusion of signaling cells. Bacterial vaginosis, which may cause preterm birth, is characterized by depletion of Lactobacilli leading to impaired vaginal barrier function. During pregnancy, a cervical mucus plug (CMP) is formed to prevent the vaginal microbes to ascend into the uterus, which protects the fetus from pathogens. CMP contains mucus, antimicrobial compounds and immune cells. A shorter, more permeable and less mucoadhesive CMP has been found in women at high risk for preterm birth compared with those at low risk. In addition to oral or vaginally administered antibiotics, bacterial vaginosis may be treated by restoring vaginal Lactobacillus flora. In conclusion, CM is essential for the fertility and protects from bacterial vaginosis and sexually transmitted infections, which increase the risk of infertility and preterm births.

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Reproductive system Microbiome Flora
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    Microbiota 12 - April 2021
    • Overview
      • Covid-19 & the gut microbiota
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    Created 24 August 2021
    Updated 12 August 2024

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    Main topic

    Pre-eclampsia

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    Press review

    Author

    Voutilainen Markku Prof Markku Voutilainen
    Skin Microbiota #12
    Focus

    Microbiota 12 - April 2021

    Overview

    Covid-19 & the gut microbiota Crosstalk between the gut microbiota and the host's immune response to combat infections

    Commented article

    Longitudinal multi-omics analysis reveals subset-specific mechanisms underlying irritable bowel syndrome Duodenal microbiota in stunted undernourished children with enteropathy

    Congress Review

    Microbiota highlights from ueg week virtual 2020

    Press review

    Gut Microbiota #12 Skin Microbiota #12 Vaginal Microbiota #12
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