Skip to main content
About the Institute
  • English
  • Français
  • Español
  • Russian
  • Portuguese
  • Polish

Breadcrumb

  1. Home
  2. Pediatrics
  3. Can microbiota prevent peanut allergy?
  • Our publications
    • News
    • Microbiota Mag
    • Thematic pages
    • Experts' point of view
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • About us
    • International Microbiota Observatory
    • Press room
    • Partnerships
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
  • Useful documents
    • How to talk about
    • Infographics
    • IBS Diagnosis Check List
    • Patients Stories

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube
    • Instagram
    • Bluesky

Lay public section

Find here your dedicated section
Gastroenterology
Gynecology
Pediatrics
General Medicine

Breadcrumb

  1. Home
  2. Pediatrics
  3. Can microbiota prevent peanut allergy?
Pediatrics

Can microbiota prevent peanut allergy?

Allergies
Gastroenterology Pediatrics

Patients who go on to develop a peanut allergy may have a specific microbial signature even before the allergy manifests, starting from their very first months of life.

Gastroenterology
Gynecology
Pediatrics
General Medicine
  • Our publications
    • News
    • Microbiota Mag
    • Thematic pages
    • Experts' point of view
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • About us
    • International Microbiota Observatory
    • Press room
    • Partnerships
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
  • Useful documents
    • How to talk about
    • Infographics
    • IBS Diagnosis Check List
    • Patients Stories

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube
    • Instagram
    • Bluesky

Lay public section

Find here your dedicated section

Sources

This article is based on scientific information

Sharing is caring

Your colleagues might be interested in this topic. Why not share it?

  • Facebook
  • Twitter
  • LinkedIn
  • Mail

About this article

Created 26 December 2023
Updated 24 June 2024

A growing body of research is pointing to the existence of distinct microbiotic signatures for different food allergies. This field of research is helping to position the microbiota as a central player in the development of such allergies. A new longitudinal study published recently in the Journal of Allergy & Clinical Immunology has shed new light on possible links between the onset of a peanut allergy and microbiota.
 
As this allergy generally develops during infancy, the researchers studied the microbiota of children at risk of developing a peanut allergy at the age of 10 months (SD: 3.1), then at 9 years (SD: 0.6). Within this population, 35 (28.7%) of the children developed a peanut allergy before the age of 9.

A different gut microbiota signature from the very first months of life

These 35 children in the PA (Peanut Allergy) group had a less diverse microbiota at inclusion (p=0.014) than the NPA (Non-Peanut Allergy) group. Their microbiota diversified with age, while that of the NPA group remained stable.

At age 9, both groups showed a comparable microbiotic diversity.

At inclusion, the PA group had a higher proportion of Clostridium sensu stricto 1 sp, while Streptococcus sp was more prevalent in the NPA group. By the age of 9, the relative abundance of these two species was normal in both populations. Conversely, the abundance of the Bifidobacterium sp species dropped in the PA group and even became higher in the NPA population.

Allergy development is identified as being associated with altered levels of 139 metabolites in the metabolome (FDR ≤ 0.05). 

These metabolites are associated with a histidine metabolism pathway (FDR = 0.037, pathway impact = 0.28).
Six short-chain fatty acids were studied in particular. The butyrate and isovalerate levels dropped in the PA group, while the isovalerate level remained stable in the NPA group with an increase in butyrate.

Microbiota 14_Mas 15.12.2021 Ethnicity associations with food sensitisation are mediated by gut microbiota development in the first year of life Read more

Is there a pathophysiological mechanism of peanut allergy?

The authors speculate that the lower microbiota diversity in PA infants may suggest that they have less stable gut communities during this phase of rapid immune system development.

The reduced relative abundance of Bifidobacterium sp, known for its use as an anti-allergy probiotic and for inducing mast cell apoptosis in mice, could also play a role in the development of allergies. 

The authors also note that the micro-organisms present in the gut of children predisposed to developing this allergy species capable of producing metabolites originating from the histidine metabolism pathway, the precursor of histamine, the effector characteristic of allergic reactions.

This study therefore advances our understanding of the close links between microbiota and allergy, and raises the question of the possible benefits of gut microbiota supplementation in preventing PA.

Recommended by our community

"A great favor to people confronting allergies" "Very good analysis"  -@LoveforSoil (From Biocodex Microbiota Institute on X)

"Very good..thank"  -@thinhhoang_tk (From Biocodex Microbiota Institute on X)

Sources

1. Chun Y, Grishin A, Rose R, Zhao W, Arditi Z, Zhang L, Wood RA, Burks AW, Jones SM, Leung DYM, Jones DR, Sampson HA, Sicherer SH, Bunyavanich S. Longitudinal dynamics of the gut microbiome and metabolome in peanut allergy development, Journal of Allergy and Clinical Immunology (2023). DOI: 10.1016/j.jaci.2023.08.012

Tags
Metabolome Peanut Immunity Microbiome Flora

    See also

    Microbiota mag 17_bandeau synthèse Microbial colonization as a determinant factor for health during the first 1000 days of life
    Microbiote déséquilibré à 1 an, allergie à 5 ans ? Does an unbalanced microbiota at age one lead to allergies at age five?
    Created 26 December 2023
    Updated 24 June 2024

    About this article

    To know more about this topic.

    Main topic

    Allergies

    Medical practice

    Gastroenterology Pediatrics

    Content type

    News
    Pediatrics

    The Janus face of Antibiotics: Life Savers and Microbiota Disruptors

    A page turns: with the advent of antibiotics in the...

    Find out more

    Focus on antibiotic associated diarrhea (AAD)

    Find out more

    Nasal microbiota: a reliable marker of bronchiolitis severity

    The severity of bronchiolitis in newborns may be as...

    Find out more

    Dampening gastrointestinal inflammation through nutrition

    by Dr Genelle Healey

    Find out more

    The infant's gut at the heart of immunity

    By Dr Travis J. De Wolfe

    Find out more

    Factors influencing microbiota development and maturation of the immune system early in life

    Birth represents the biggest substantial environmen...

    Find out more

    From diarrhea to chronic diseases: the well-documented consequences of antibiotic-related gut microbiota dysbiosis

    Antibiotic treatment may sometimes take place witho...

    Find out more

    51st annual Meeting ESPGHAN

    Congress review By Dr. Solange Heller Rouassant Pediatrician with specialty in Pediatric Gastroenter...

    Find out more

    Continue reading

    News
    Actu PRO : Malnutrition : agir sur le microbiote pour améliorer la croissance, un prototype à l’essai
    08.07.2021

    Malnutrition: acting on the microbiota in order to improve growth, a trial prototype

    Read the article
    22.11.2023

    Is vaginal microbiota transfer the new miracle for C-section babies?

    Read the article
    Everything you need to know about Microbiota & Immunity
    15.09.2022

    Everything you need to know about Microbiota & Immunity

    Read the article
    03.07.2024

    Gut dysbiosis in men: what are the consequences for their children?

    Read the article
    Intestinal bacteria, illustration.
    24.08.2023

    Everything you need to know about probiotics

    Read the article
    11.03.2022

    When an infant’s sleep hinges on a few bacteria

    Read the article
    04.03.2022

    Antibiotics and cesarean delivery: how do they affect the newborn microbiota?

    Read the article
    Photo: Atténuer la dénutrition avec des biotiques ?
    26.04.2023

    Mitigating malnutrition with biotics?

    Read the article
    • Our publications
      • News
      • Microbiota Mag
      • Thematic pages
      • Experts' point of view
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • About us
      • International Microbiota Observatory
      • Press room
      • Partnerships
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
    • Useful documents
      • How to talk about
      • Infographics
      • IBS Diagnosis Check List
      • Patients Stories

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube
      • Instagram
      • Bluesky

    Lay public section

    Find here your dedicated section
    Gastroenterology
    Gynecology
    Pediatrics
    General Medicine
    • English
    • Français
    • Español
    • Russian
    • Portuguese
    • Polish

    Browse the site

    • Our publications
      • News
      • Microbiota Mag
      • Thematic pages
      • Experts' point of view
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • About us
      • International Microbiota Observatory
      • Press room
      • Partnerships
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
    • Useful documents
      • How to talk about
      • Infographics
      • IBS Diagnosis Check List
      • Patients Stories

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube
      • Instagram
      • Bluesky

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    General Medicine

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube
    • Instagram
    • Bluesky

    Lay public section

    Find here your dedicated section

    Redirection

    You are about to be redirected and leave our website

    • Be redirected
    • Stay on the Biocodex Microbiota Institute's website

    Stay with us !

    Join the Microbiota Community of HCPs and researchers and receive “Microbiota Digest” and "Microbiota Mag" to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    Explore

    14.05.2025

    Towards worldwide redefinition of healthy vaginal microbiota

    Read the article
    07.05.2025

    The microbial-metabolic nexus in colon cancer

    Read the article
    02.05.2025

    A new lens on chlamydia: beyond behavior, into the microbiome

    Read the article

    Stay updated

    Join the Microbiota Community of HCPs and researchers and receive “Microbiota Digest” and "Microbiota Mag" to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    • Our publications
      • News
      • Microbiota Mag
      • Thematic pages
      • Experts' point of view
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • About us
      • International Microbiota Observatory
      • Press room
      • Partnerships
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
    • Useful documents
      • How to talk about
      • Infographics
      • IBS Diagnosis Check List
      • Patients Stories

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube
      • Instagram
      • Bluesky

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    General Medicine

    Lay public section

    Find here your dedicated section

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube
    • Instagram
    • Bluesky

    © 2025 Biocodex. All rights reserved.

    • Legal notice
    • GTU
    • Data protection policy
    • Sitemap
    • Cookies settings
    • Digital accessibility : partially compliant
    Biocodex logo