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Does an unbalanced microbiota at age one lead to allergies at age five?

Allergies
Pediatrics Pulmonology Gastroenterology

Delayed maturation of the gut microbiota in early childhood appears to be a universal sign of subsequent allergy development. Could the metabolites involved serve as markers for these allergies or even help prevent them?

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Microbiote déséquilibré à 1 an, allergie à 5 ans ?

About this article

Created 10 November 2023
Updated 14 November 2023

Asthma, allergic rhinitis, food allergies, and atopic dermatitis are often studied on their own, despite having many similar mechanisms (inflammatory responses, immunoglobulin E). Could something else they have in common be the gut microbiota, which matures in parallel with the infant immune system? To find out, data from 1,115 children included in the vast (sidenote: https://childstudy.ca/ ) longitudinal study were used: 592 children diagnosed with one or more allergic disorders after the age of 5, and 523 children with no signs of allergic sensitization. Regression analysis revealed several risk factors, such as male gender, paternal or maternal history, and antibiotic use before the age of one. Breastfeeding up to six months of age and Caucasian ethnicity appear to be protective.

Less mature gut microbiota

An analysis of stool samples collected at three months and one year of age revealed a delay in microbiota diversification in the children who subsequently developed allergies. Whereas control children had age-appropriate gut flora at age one, future allergic children showed a delay in the maturation of their microbiota. Less maturation of the microbiota at age one seems to be associated with an increased risk of allergic disorders at age five, regardless of the allergy.

24.06.2021 Gut microbiota not yet considered “adult” at 5 years old? Read more

Gut microbiota dysbiosis

A gut dysbiosis at age one also characterizes future allergic children: depleted levels of four bacterial species that produce short-chain fatty acids (butyrate-producing Anaerostipes hadrus, Fusicatenibacter saccharivorans and Eubacterium hallii, and acetate-producing Blautia wexlerae) and an increased abundance of five bacteria generally considered pathogenic (Eggerthella lenta, Escherichia coli, Enterococcus faecalis, Clostridium innocuum, and Tyzzerella nexilis). Enrichment in C. innocuum and T. nexilis is correlated with antibiotic use; the abundance of C. innocuum, E. lenta, E. faecalis, and T. nexilis depends on whether or not the baby is breast-fed at six months; while the abundance of C. innocuum and E. lenta is correlated with paternal atopy, and so on.

Actu PRO : Moins d’antibiotiques, moins de dysbiose, moins d’asthme pédiatrique 10.06.2020 Fewer antibiotics, less dysbiosis, less childhood asthma Read more

Metabolites to predict or prevent?

In parallel, the researchers identified 11 metabolic pathways significantly altered in at least two of the allergy diagnoses: nine deleterious pathways correlated mainly with E. coli, while two protective pathways were linked to the bacteria B. wexlerae, F. saccharivorans, A. hadrus, and E. hallii.
A metabolite analysis led to associations with age predicted by the gut microbiota: elevated trace amines (phenylethylamine, tryptamine, and tyramine) promoted inflammation and reduced butyrate production. Thus, the association between altered microbiota maturation and allergies at age five appears to be mediated by these metabolites, which may represent first-choice targets for predicting and/or preventing the development of pediatric allergies.

Microbiota, a diplomatic immunity?

Learn more
Sources

Hoskinson C, Dai DLY, Del Bel KL et al. Delayed gut microbiota maturation in the first year of life is a hallmark of pediatric allergic disease. Nat Commun. 2023 Aug 29;14(1):4785. doi: 10.1038/s41467-023-40336-4.

Tags
Allergies Food allergies Allergic rhinitis Dysbiosis Butyrate Microbiome Flora

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    Created 10 November 2023
    Updated 14 November 2023

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