Skip to main content
About the Institute
  • English
  • Français
  • Español
  • Russian
  • Portuguese

Breadcrumb

  1. Home
  2. Gastroenterology
  3. Could the gut microbiota be a tuberculosis signature?
  • Our publications
    • News
    • Microbiota Mag
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • Partnerships
    • Press room
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
    • Xpeer App
  • Useful documents
    • Infographics
    • IBS Diagnosis Check List
    About the Institute

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

Lay public section

Find here your dedicated section
Gastroenterology
Gynecology
Pediatrics
Dermatology

Breadcrumb

  1. Home
  2. Gastroenterology
  3. Could the gut microbiota be a tuberculosis signature?
Gastroenterology

Could the gut microbiota be a tuberculosis signature?

Tuberculosis
Pulmonology Gastroenterology

While tuberculosis-associated disruptions of the gut microbiota have already been described, a study went even further in the characterization of this dysbiosis and identified some species that signal this disease.

Gastroenterology
Gynecology
Pediatrics
Dermatology
  • Our publications
    • News
    • Microbiota Mag
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • Partnerships
    • Press room
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
    • Xpeer App
  • Useful documents
    • Infographics
    • IBS Diagnosis Check List
    About the Institute

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

Lay public section

Find here your dedicated section

Sources

This article is based on scientific information

Sharing is caring

Your colleagues might be interested in this topic. Why not share it?

  • Facebook
  • Twitter
  • LinkedIn
  • Mail

About this article

Created 15 July 2019
Updated 02 November 2021

 

The ability of the gut microbiota to remotely communicate with organs such as the brain, liver or lungs has often been reported in the scientific literature, as well as associations between dysbiosis and some diseases. In this context, a Chinese team focused on the gut microbiota specificities of patients with tuberculosis (TB) caused by Mycobacterium tuberculosis.To describe them, the researchers compared the microbiota of 46 patients with TB to that of 31 control subjects, using (sidenote:  Shotgun sequencing method is more accurate than 16S rARN. ) .

Less diversified gut microbiota

First finding: the microbiota of patients with TB showed significantly lower bacterial abundance and diversity (Shannon index). It was also characterized by a decreased or increased presence of some species compared to the control group. In total, 23 species were less abundant in the microbiota of patients with TB, while 2 were more abundant (unclassified Coprobacillus and Clostridum bolteae).

Decreased SCFA metabolism

Another notable finding: among the 23 decreased bacterial species in patients with TB, 9 produce short-chain fatty acids (SCFA), components which are largely involved in inflammatory and immune responses. In particular, five butyrate-producing species (Roseburia inulinivorans, R. hominis, R. intestinalis, Eubacterium rectale and Coprococcus comes), two lactate- and acetate-producing species (Bifidobacterium adolescentis and B. longum) and two acetate- and propionate- producing species (Ruminococcus obeum and Akkermansia muciniphila) were found in decreased amounts. In line with these changes in bacterial composition, SCFA fermentation was significantly lower in patients with TB.

Identifying tuberculosis patients based on their microbiota?

Finally, based on modeling studies, the researchers characterized 3 bacterial species (Haemophilus parainfluenzae, R. inulinivorans and R. hominis) whose presence could discriminate between healthy and tuberculosis patients. The healthy and diseased states could also be distinguished by some genetic variations (SNP, Single Nucleotide Polymorphism) in the B. vulgaris species. As for several disorders affecting different body systems (type 2 diabetes, autism, etc.), tuberculosis seems to be associated to a dysbiosis of the gut microbiota. However, it is not yet possible to determine whether it is a cause or a consequence of the disease, since mechanistic data currently available from animal studies are compatible with both hypotheses.

 

Sources

Hu Y, Feng Y, Wu J et al. The Gut Microbiome Signatures Discriminate Healthy From Pulmonary Tuberculosis Patients. Front Cell Infect Microbiol. 2019 Apr 3;9:90. 

Tags
Predicator Tuberculosis Short-chain fatty acid SCFA Lungs

en_view en_sources

    Created 15 July 2019
    Updated 02 November 2021

    About this article

    To know more about this topic.

    Main topic

    Tuberculosis

    Medical practice

    Pulmonology Gastroenterology

    Content type

    News
    Gastroenterology

    Everything you need to know about Irritable Bowel Syndrome (IBS)

    Accrediting training, infographics, expert’s video,...

    Find out more

    Your IBS Diagnosis Check List

    How many patients suffering from gut disorder do you see per week? How many are diagnosed with Irrita...

    Find out more

    Human milk nutrient fortifiers alter the developing gastrointestinal microbiota of very-low-birth-weight infants

    Commented article - Children's section By Pr. Emma...

    Find out more

    Impact of beer and non alcoholic consumption on the gut microbiota

    By Pr. Bernd SchnablDivision of Gastroenterology, S...

    Find out more

    Gut Microbiota #17

    By Pr. Satu PekkalaAcademy of Finland Research Fellow, Faculty of Sport and Health Sciences, Universi...

    Find out more

    Gut Microbiota # 16

    By Pr. Satu PekkalaAcademy of Finland Research Fellow, Faculty of Sport and Health Sciences, Universi...

    Find out more

    Highlights from the UEGW

    By Dr. Lucas WautersGastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium ...

    Find out more

    The Gut-Brain axis

    By Pr. Sarkis K. Mazmanian, John W. Bostick, Nadia SuryawinataBiology and Biological Engineering, Cal...

    Find out more

    Continue reading

    News
    SII, microbiote intestinal et dépression : un triptyque pour mieux comprendre la maladie
    27.07.2022

    IBS, gut microbiota and depression: a trio shedding light on the disease

    Read the article
    Actu PRO : Cancer du poumon : le microbiote intestinal signerait un stade précoce
    02.07.2020

    Gut microbiota could be an indicator of early-stage lung cancer

    Read the article
    Obesity: Is a bacterial fatty acid involved?
    15.05.2023

    Obesity: Is a bacterial fatty acid involved?

    Read the article
    Photo: Endométriose : une clé de sa progression au sein du microbiote intestinal
    09.05.2023

    Endometriosis: A key to its progression in the gut microbiota?

    Read the article
    16.11.2022

    Alcohol use disorders: in microbiota veritas?

    Read the article
    Photo: Atténuer la dénutrition avec des biotiques ?
    26.04.2023

    Mitigating malnutrition with biotics?

    Read the article
    25.04.2023

    F. prausnitzii : a biomarker of chronic fatigue syndrome

    Read the article
    Photo: Quand les interactions sociales façonnent nos microbiotes
    05.04.2023

    The role of social interactions in shaping our microbiota

    Read the article
    What's worth reading about microbiota
    Follow us on Twitter
    Read our thematic folder
    The Janus face of Antibiotics: Life Savers & Microbiota Disrupters
    Microbiota 17 EN
    Check out our latest magazine
    The first 1000 days of life
    • Our publications
      • News
      • Microbiota Mag
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographics
      • IBS Diagnosis Check List
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube

    Lay public section

    Find here your dedicated section
    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology
    • English
    • Français
    • Español
    • Russian
    • Portuguese

    Browse the site

    • Our publications
      • News
      • Microbiota Mag
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographics
      • IBS Diagnosis Check List
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

    Lay public section

    Find here your dedicated section

    Redirection

    You are about to be redirected and leave our website

    • Be redirected
    • Stay on the Biocodex Microbiota Institute's website

    Stay with us !

    Join the Microbiota Community of HCPs and researchers and receive “Microbiota Digest” and "Microbiota Mag" to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    Explore

    Obesity: Is a bacterial fatty acid involved?
    15.05.2023

    Obesity: Is a bacterial fatty acid involved?

    Read the article
    Photo: Endométriose : une clé de sa progression au sein du microbiote intestinal
    09.05.2023

    Endometriosis: A key to its progression in the gut microbiota?

    Read the article
    Photo: Atténuer la dénutrition avec des biotiques ?
    26.04.2023

    Mitigating malnutrition with biotics?

    Read the article

    Stay updated

    Join the Microbiota Community of HCPs and researchers and receive “Microbiota Digest” and "Microbiota Mag" to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    • Our publications
      • News
      • Microbiota Mag
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographics
      • IBS Diagnosis Check List
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology

    Lay public section

    Find here your dedicated section

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

    © 2022 Biocodex. All rights reserved.

    • Cookies Policy
    • Data protection policy
    • GTU
    • Sitemap
    • Cookies settings
    Biocodex logo