Skip to main content
About the Institute
  • English
  • Français
  • Español
  • Russian
  • Portuguese
  • Polish

Breadcrumb

  1. Home
  2. Gastroenterology
  3. Green Mediterranean diet: what links between cardiometabolic health and gut microbiota?
  • Our publications
    • News
    • Microbiota Mag
    • Thematic pages
    • Experts' point of view
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • About us
    • International Microbiota Observatory
    • Press room
    • Partnerships
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
  • Useful documents
    • How to talk about
    • Infographics
    • IBS Diagnosis Check List
    • Patients Stories

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube
    • Instagram
    • Bluesky

Lay public section

Find here your dedicated section
Gastroenterology
Gynecology
Pediatrics
General Medicine

Breadcrumb

  1. Home
  2. Gastroenterology
  3. Green Mediterranean diet: what links between cardiometabolic health and gut microbiota?
Gastroenterology

Green Mediterranean diet: what links between cardiometabolic health and gut microbiota?

Diet
Gastroenterology

The well-established benefits of the Mediterranean diet on cardiovascular health may involve the gut microbiota. Work by Israeli researchers published in Genome Medicine1 reveals the impact of an even more plant-rich diet on the microbial structure and enzymatic activity of the gut flora, weight loss and several cardiometabolic markers.

Gastroenterology
Gynecology
Pediatrics
General Medicine
  • Our publications
    • News
    • Microbiota Mag
    • Thematic pages
    • Experts' point of view
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • About us
    • International Microbiota Observatory
    • Press room
    • Partnerships
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
  • Useful documents
    • How to talk about
    • Infographics
    • IBS Diagnosis Check List
    • Patients Stories

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube
    • Instagram
    • Bluesky

Lay public section

Find here your dedicated section

Sources

This article is based on scientific information

Sharing is caring

Your colleagues might be interested in this topic. Why not share it?

  • Facebook
  • Twitter
  • LinkedIn
  • Mail
Photo: Régime méditerranéen « vert » : quels liens entre santé cardiométabolique et microbiote intestinal ?

About this article

Created 10 June 2022
Updated 25 June 2024

It is a diet that is now unanimously recommended by the international learned societies of cardiology and diabetology. 2,3,4 Epidemiological studies show that the Mediterranean diet is associated with better general health and a significant reduction in cardiometabolic risks.  Recent studies go further and suggest an additional benefit on morbi-mortality of the reduction of animal proteins and fats in favor of their vegetable equivalents (nuts, seeds, olive oil, etc.) in the Mediterranean diet.

Green-Med, a diet based on plants and their polyphenols

Researchers have conducted a study corroborating these results while providing a better understanding of the role of the microbiota in these effects. They randomized 294 participants from the DIRECT-PLUS5 cohort over 30 years of age (88% men) with abdominal obesity and/or dyslipidemia into three groups: standard healthy diet recommendations, Mediterranean diet and "Green-Med", an "optimized" Mediterranean diet. The Green-Med incorporates Mankai duckweed (100 g per day), an Asian plant rich in fiber and plant protein that reduces the amount of meat, and green tea (3 to 4 cups per day). The authors highlighted the high content of polyphenols in these foods, which are capable of modifying the taxonomic structure of the intestinal microbiota and intervening in fat metabolism. 6 Both diets were supplemented with nuts (28g per day) and were isocaloric and restrictive (1500-1800 kcal for men and 1200-1400 kcal for women). All three groups combined the diet with moderate physical activity.

Changes in the structure and enzymatic activity of the microbiota

Fecal samples from the participants were collected and analyzed by sequencing at baseline and at 6 months. All subjects showed changes in the structure of their gut microbiota. Green-Med led to even more substantial changes, mainly in its rare (<50%), person-specific, and diet-influenced species. Specifically, it led to an increase in Prevotella, signaling adherence to a "vegetarian" diet, and a decrease in Bifidobacteria, known to improve dietary glycemic index and facilitate weight loss. The researchers also found a reduction in the biosynthesis of branched-chain amino acids, metabolites involved in obesity and insulin resistance. 

Superior results on weight and cardiometabolic markers

The Green-Med was more effective in terms of weight loss (-6.5% vs -5.4% for the Mediterranean diet and -1.58% for the standard diet). In addition, improvements following a similar trend were observed on markers of cardiovascular risk, with a decrease in Framingham score, waist circumference, mean blood pressure, insulin resistance and plasma leptin levels.

-6,5 % Green-Med

-5,4 % Mediterranean diet

-1,58 % standard diet

 According to the researchers' modelling, these benefits are partly related to the impact of changes in the microbiota caused by Green-Med, contributing for example to 12% of the weight loss and 18% in the reduction of the Framingham score.

For the authors, this study highlights the food-microbiota-host interactions and confirms the benefits of the Green MED diet on cardiometabolic health, whose effects are partly mediated by a change in the composition and function of the host gut microbiome.

Sources

1. Rinott E, Meir AY, Tsaban G et al. The effects of the Green-Mediterranean diet on cardiometabolic health are linked to gut microbiome modifications: a randomized controlled trial. Genome Med. 2022 Mar 10;14(1):29

2. Visseren FLJ, Mach F, Smulders YM, et al. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice. Eur Heart J. 2021 Sep 7;42(34):3227-3337

3. Arnett DK, Blumenthal RS, Albert MA, et al. 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines, Circulation. 2019 Sep 10;140(11):e596-e646

4. American Diabetes Association AD. 4. Lifestyle management: standards of medical care in diabetes-2018. Diabetes Care. 2018;41(Suppl 1):S38–50.

5. Tsaban G, Meir AY, Rinott E, et al. The effect of green Mediterranean diet on cardiometabolic risk; a randomised controlled trial Cardiac risk factors and prevention. Heart. 2020;0:1–8.

6. Huang J, Wang Y, Xie Z et al. The anti-obesity effects of green tea in human intervention and basic molecular studies. Eur J Clin Nutr. 2014 Oct;68(10):1075-87

Tags
Mediterranean diet Diet Cardiovascular disease Food Microbiome Flora

    See also

    Could fibers modify the microbiota?
    Dampening gastrointestinal inflammation through nutrition
    Created 10 June 2022
    Updated 25 June 2024

    About this article

    To know more about this topic.

    Main topic

    Diet

    Medical practice

    Gastroenterology

    Content type

    News
    Gastroenterology

    Association between fungal dysbiosis and environment

    The fungal portion of the gut microbiota (or mycobiota) has been much less studied than the bacterial...

    Find out more

    Your IBS Diagnosis Check List

    How many patients suffering from gut disorder do you see per week? How many are diagnosed with Irrita...

    Find out more

    Probiotics: what exactly are we talking about?

    From the Latin pro and Greek bios meaning “for life”, the term “probiotic” was suggested over 60 year...

    Find out more

    How do you choose a probiotic for your patient?

    Faced with a plethora of products on the market, it's not always easy for health professionals to sug...

    Find out more

    The Janus face of Antibiotics: Life Savers and Microbiota Disruptors

    A page turns: with the advent of antibiotics in the...

    Find out more

    Fecal transplantation - ready for prime time?

    Congress review By Pr. Danny De Looze Department of Gastroenterology University Hospital Gent, Belgi...

    Find out more

    Focus on antibiotic associated diarrhea (AAD)

    Find out more

    Dampening gastrointestinal inflammation through nutrition

    by Dr Genelle Healey

    Find out more

    Continue reading

    News
    Actu PRO : Malnutrition : agir sur le microbiote pour améliorer la croissance, un prototype à l’essai
    08.07.2021

    Malnutrition: acting on the microbiota in order to improve growth, a trial prototype

    Read the article
    07.05.2025

    The microbial-metabolic nexus in colon cancer

    Read the article
    07.02.2025

    Your functional dyspepsia diagnosis check list

    Read the article
    17.04.2025

    Sensitivity to the additive E466: the role of the microbiota

    Read the article
    Photo HCPs: Clinical context over quick fix: the fresh consensus on microbiome testing
    11.04.2025

    Clinical context over quick fix: the fresh consensus on microbiome testing

    Read the article
    22.11.2023

    Is vaginal microbiota transfer the new miracle for C-section babies?

    Read the article
    Actu PRO : Alcoolisme : expliquer les troubles sociaux grâce au microbiote
    27.01.2021

    Alcoholism: explaining social disorders thanks to the microbiota

    Read the article
    20.03.2025

    Entacapone and the gut: a hidden impact on parkinson’s care

    Read the article
    • Our publications
      • News
      • Microbiota Mag
      • Thematic pages
      • Experts' point of view
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • About us
      • International Microbiota Observatory
      • Press room
      • Partnerships
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
    • Useful documents
      • How to talk about
      • Infographics
      • IBS Diagnosis Check List
      • Patients Stories

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube
      • Instagram
      • Bluesky

    Lay public section

    Find here your dedicated section
    Gastroenterology
    Gynecology
    Pediatrics
    General Medicine
    • English
    • Français
    • Español
    • Russian
    • Portuguese
    • Polish

    Browse the site

    • Our publications
      • News
      • Microbiota Mag
      • Thematic pages
      • Experts' point of view
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • About us
      • International Microbiota Observatory
      • Press room
      • Partnerships
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
    • Useful documents
      • How to talk about
      • Infographics
      • IBS Diagnosis Check List
      • Patients Stories

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube
      • Instagram
      • Bluesky

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    General Medicine

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube
    • Instagram
    • Bluesky

    Lay public section

    Find here your dedicated section

    Redirection

    You are about to be redirected and leave our website

    • Be redirected
    • Stay on the Biocodex Microbiota Institute's website

    Stay with us !

    Join the Microbiota Community of HCPs and researchers and receive “Microbiota Digest” and "Microbiota Mag" to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    Explore

    14.05.2025

    Towards worldwide redefinition of healthy vaginal microbiota

    Read the article
    07.05.2025

    The microbial-metabolic nexus in colon cancer

    Read the article
    02.05.2025

    A new lens on chlamydia: beyond behavior, into the microbiome

    Read the article

    Stay updated

    Join the Microbiota Community of HCPs and researchers and receive “Microbiota Digest” and "Microbiota Mag" to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    • Our publications
      • News
      • Microbiota Mag
      • Thematic pages
      • Experts' point of view
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • About us
      • International Microbiota Observatory
      • Press room
      • Partnerships
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
    • Useful documents
      • How to talk about
      • Infographics
      • IBS Diagnosis Check List
      • Patients Stories

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube
      • Instagram
      • Bluesky

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    General Medicine

    Lay public section

    Find here your dedicated section

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube
    • Instagram
    • Bluesky

    © 2025 Biocodex. All rights reserved.

    • Legal notice
    • GTU
    • Data protection policy
    • Sitemap
    • Cookies settings
    • Digital accessibility : partially compliant
    Biocodex logo