Skip to main content
About the Institute
  • English
  • Français
  • Español
  • Russian
  • Portuguese

Breadcrumb

  1. Home
  2. Gastroenterology
  3. Crohn’s disease: is the ileal microbiota a predictive factor of recurrence?
  • Our publications
    • News
    • Microbiota Mag
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • Partnerships
    • Press room
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
    • Xpeer App
  • Useful documents
    • Infographics
    About the Institute

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

Lay public section

Find here your dedicated section
Gastroenterology
Gynecology
Pediatrics
Dermatology

Breadcrumb

  1. Home
  2. Gastroenterology
  3. Crohn’s disease: is the ileal microbiota a predictive factor of recurrence?
Gastroenterology

Crohn’s disease: is the ileal microbiota a predictive factor of recurrence?

Crohn's disease
Gastroenterology

Using the gut microbiota to predict postoperative recurrence in Crohn’s disease: such is the possibility raised by a French study conducted in patients who underwent bowel resection.

Gastroenterology
Gynecology
Pediatrics
Dermatology
  • Our publications
    • News
    • Microbiota Mag
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • Partnerships
    • Press room
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
    • Xpeer App
  • Useful documents
    • Infographics
    About the Institute

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

Lay public section

Find here your dedicated section

Sources

This article is based on scientific information

Sharing is caring

Your colleagues might be interested in this topic. Why not share it?

  • Facebook
  • Twitter
  • Mail
Actu PRO : Crohn : le microbiote iléal, facteur prédictif de récidive ?

About this article

Created 29 October 2019
Updated 06 October 2021

 

While 50 to 75% of patients with Crohn’s disease will require at least one bowel resection during their lifetime, recurrence is observed in about 50% of them in the 5 years following their operation. Endoscopy is the gold-standard method to diagnose relapse. However, it can only be carried out a few months after the operation, thus delaying a potentially necessary early therapeutic intervention. The identification of early predictive factors of recurrence is thus of major interest.

Persistent dysbiosis

According to a multicenter study published in Gut and headed by Pr. Harry Sokol’s team, the microbiota present in the ileal mucosa could very well be one of these factors. To reach this conclusion, the researchers analyzed the composition of the microbiota extracted during bowel resection surgery (Tr), and later during follow-up endoscopy (Ts), in 201 patients. Result? Bowel resection caused a significant change in the microbiota in all patients and an improvement of the initial dysbiosis, but its effects were less pronounced in those who were relapsing. In the latter, between Tr and Ts, there was a decrease of alpha diversity, a more significant increase of several species from the Alphaproteobacteria class, and a lesser increase in some species from the Firmicutes phylum and the Lachnospiraceae and Ruminococcaceae families, which are believed to be markers of intestinal health.

Using the microbiota to predict recurrence

In modeling studies (some models take into account the factors modulating the recurrence risk: previous resection, tobacco use, male gender are aggravating factors while (sidenote: anti-TNF (Tumor Necrosis Factor) drugs are used to control inflammation. )  use is a protective factor), the researchers went further by identifying several taxa that are overabundant during the resection and that could be significant recurrence markers, especially bacteria from the Gammaproteobacteria class, Ruminococcus gnavus group and Corynebacterium genus. Despite some limitations, this study suggests that the composition of the microbiota at the time of bowel resection could predict recurrence and steer the postoperative therapeutic approach. There are however obstacles to the implementation of such an approach, especially the frequent preoperative use of antibiotics, which alter the microbiota and jeopardize its use as a predictive tool.

 

Sources

Sokol H, Brot L, Stefanescu C et al. Prominence of ileal mucosa-associated microbiota to predict postoperative endoscopic recurrence in Crohn's disease. Gut. 2020 Mar;69(3):462-472.

Tags
IBD Predictor Crohn’s disease Ileal microbiota Resection Recurrence

en_view en_sources

    Created 29 October 2019
    Updated 06 October 2021

    About this article

    To know more about this topic.

    Main topic

    Crohn's disease

    Medical practice

    Gastroenterology

    Content type

    News
    Gastroenterology

    Everything you need to know about Irritable Bowel Syndrome (IBS)

    Accrediting training, infographics, expert’s video, thematic folder, news… Biocodex Microbiota Institute pr...

    Find out more

    Your IBS Diagnosis Check List

    How many patients suffering from gut disorder do you see per week? How many are diagnosed with Irritable Bo...

    Find out more

    Gut Microbiota #17

    By Pr. Satu PekkalaAcademy of Finland Research Fellow, Faculty of Sport and Health Sciences, University of ...

    Find out more

    Impact of beer and non alcoholic comsumption on the gut microbiota

    By Pr. Bernd SchnablDivision of Gastroenterology, San Diego Digestive Diseases Research Center (SDDRC), UC ...

    Find out more

    Gut Microbiota # 16

    By Pr. Satu PekkalaAcademy of Finland Research Fellow, Faculty of Sport and Health Sciences, University of ...

    Find out more

    Highlights from the UEGW

    By Dr. Lucas WautersGastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium

    Find out more

    The Gut-Brain axis

    By Pr. Sarkis K. Mazmanian, John W. Bostick, Nadia SuryawinataBiology and Biological Engineering, Californi...

    Find out more

    Human milk nutrient fortifiers alter the developing gastrointestinal microbiota of very-low-birth-weight infants

    Commented article - Children's section By Pr. Emmanuel M...

    Find out more

    Continue reading

    News
    23.01.2023

    Idiopathic urethritis in men: new infectious etiologies?

    Read the article
    13.01.2023

    Insomnia in seniors: a link with the gut microbiota

    Read the article
    03.01.2023

    Almonds: limited effects on the gut microbiota

    Read the article
    14.12.2022

    Microplastics in takeaway food put gut and oral flora at risk

    Read the article
    16.12.2022

    Does the gut microbiota influence vaccine efficacy?

    Read the article
    05.12.2022

    Can gut bacteria and metabolites help the earlier prediction of necrotizing enterocolitis in newborns?

    Read the article
    Photo: WAAW 2022 (HCPs)
    25.10.2022

    Microbiota at the forefront of antibiotic resistance

    Read the article
    25.10.2022

    Antibiotics: Dr Jekyll and Mr Hyde

    Read the article
    What's worth reading about microbiota
    Follow us on Twitter
    Read our thematic folder
    The Janus face of Antibiotics: Life Savers & Microbiota Disrupters
    NL13_cover
    Check out latest newsletter
    IBS, Microbiota & Covid-19
    • Our publications
      • News
      • Microbiota Mag
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographics
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube

    Lay public section

    Find here your dedicated section
    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology
    • English
    • Français
    • Español
    • Russian
    • Portuguese

    Browse the site

    • Our publications
      • News
      • Microbiota Mag
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographics
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

    Lay public section

    Find here your dedicated section

    Redirection

    You are about to be redirected and leave our website

    • Be redirected
    • Stay on the Biocodex Microbiota Institute's website

    Stay with us !

    Join the Microbiota Community of HCPs and researchers and receive “Microbiota Digest” and "Microbiota Mag" to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    Explore

    23.01.2023

    Idiopathic urethritis in men: new infectious etiologies?

    Read the article

    Impact of beer and non alcoholic comsumption on the gut microbiota

    By Pr. Bernd SchnablDivision of Gastroenterology, San Diego Digestive Diseases Research Center (SDDRC), UC ...

    Find out more

    Skin Microbiota #17

    By Pr. Satu PekkalaAcademy of Finland Research Fellow, Faculty of Sport and Health Sciences, University of ...

    Find out more

    Stay updated

    Join the Microbiota Community of HCPs and researchers and receive “Microbiota Digest” and "Microbiota Mag" to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    • Our publications
      • News
      • Microbiota Mag
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographics
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology

    Lay public section

    Find here your dedicated section

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

    © 2022 Biocodex. All rights reserved.

    • Cookies Policy
    • Data protection policy
    • GTU
    • Sitemap
    • Cookies settings
    Biocodex logo