Skip to main content
About the Institute
  • English
  • Français
  • Español
  • Russian
  • Portuguese
  • Polish

Breadcrumb

  1. Home
  2. Gastroenterology
  3. Gut dysbiosis in SARS-CoV-2 infected monkeys
  • Our publications
    • News
    • Microbiota Mag
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • Partnerships
    • Press room
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
    • Xpeer App
  • Useful documents
    • Infographics
    • IBS Diagnosis Check List
    About the Institute

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

Lay public section

Find here your dedicated section
Gastroenterology
Gynecology
Pediatrics
Dermatology

Breadcrumb

  1. Home
  2. Gastroenterology
  3. Gut dysbiosis in SARS-CoV-2 infected monkeys
Gastroenterology

Gut dysbiosis in SARS-CoV-2 infected monkeys

Covid-19
Pulmonology Gastroenterology

A French team from the Lille Center for Infection and Immunity, in collaboration with CEA, INRAE, the Pasteur Institute and the Saint-Antoine Hospital in Paris, has shown that SARS-CoV-2, the virus that causes Covid-19, provokes a gut dysbiosis in monkeys which persists even after the virus has been eliminated.

Gastroenterology
Gynecology
Pediatrics
Dermatology
  • Our publications
    • News
    • Microbiota Mag
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • Partnerships
    • Press room
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
    • Xpeer App
  • Useful documents
    • Infographics
    • IBS Diagnosis Check List
    About the Institute

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

Lay public section

Find here your dedicated section

Sources

This article is based on scientific information

Sharing is caring

Your colleagues might be interested in this topic. Why not share it?

  • Facebook
  • Twitter
  • LinkedIn
  • Mail
Actu PRO : Dysbiose intestinale chez les macaques infectés par le SARS-CoV-2

About this article

Created 08 June 2021
Updated 30 March 2022

The tightly regulated interplay between gut microbiota and host influences many physiological functions including immune homeostasis. A body of preclinical and clinical evidence shows that gut microbiota composition is transiently altered in the context of acute viral respiratory infections. In the case of Covid-19, studying the gut microbiota during infection is particularly important, given that SARS-CoV-2 can bind to ACE2 receptors in the gut, the virus is found in the intestine in up to 25% of patients, and the gut microbiota alterations associated with pulmonary and intestinal complications are likely to influence disease severity. This preclinical study is the first to investigate the role of SARS-CoV-2 infection in dynamic changes in the gut microbiota of monkeys.

The monkey: a good model for SARS-CoV-2 infection

The human data currently available on Covid-19 are abundant but do not allow the disease to be followed throughout its course, from pre-infection to post-resolution. The researchers used two species of monkeys (cynomolgus monkey and rhesus monkey) to fill in certain missing pieces of the infection puzzle. These non-human primates are a suitable model for the study of Covid-19, since SARS-CoV-2 infection led to virus replication in their upper and lower respiratory tracts, resulting in lung pathology and respiratory disease with no overt clinical symptoms. Two monkeys from each species were infected intranasally and intratracheally. Blood (to measure cytokine levels) and stool samples were collected 9 days prior to infection and at 0, 3, 5, 7, 10, 13, 20, and 26 days post-infection (dpi). Two of the monkeys had transient diarrhea at 4 dpi.

Covid-19: persistent dysbiosis even after resolution...

16S rRNA gene sequencing revealed significant changes in the composition of the monkeys’ gut microbiota, with a peak at 10-13 dpi. Some alterations in the microbiota persisted after SARS-CoV-2 was eliminated from the upper respiratory tract (virus undetectable in the nasopharynx and trachea at 20 dpi, but still detectable in the stool of two monkeys) and even at 26 dpi. A significant number of changes in the abundance of bacterial taxa were observed during infection, particularly at 13 dpi. In particular, the relative abundance of Acinetobacter and some genera of the Ruminococcaceae family was positively correlated with the presence of SARS-CoV-2 in the upper respiratory tract.

...and a gut microbiota with altered functional activity

A metabolomic approach was used to evaluate the functional consequences of the changes in the gut microbiota associated with the infection. The aim here was to quantify three of the most important categories of microbiota-derived metabolites: short-chain fatty acids (SCFAs), bile acids, and tryptophan metabolites. SCFA levels changed over the course of the infection, particularly between 2 and 13 dpi. Changes in several bile acids and tryptophan metabolites were also identified in infected animals. The relative abundance of several taxa known to be SCFA producers (mostly from the Ruminococcaceae family) was negatively correlated with certain systemic inflammatory markers, while the genus Streptococcus was strongly and positively correlated with the same markers. This study shows that experimental infection with SARS-CoV-2 in monkeys is associated with a disruption of the gut microbiota’s composition and functional activity. The persistence of dysbiosis after resolution of the infection may play a role in the long Covid-19 symptoms currently being reported in humans.

Sources

Sokol H, Contreras V, Maisonnasse P, et al. SARS-CoV-2 infection in nonhuman primates alters the composition and functional activity of the gut microbiota. Gut Microbes. 2021;13(1):1-19.

Tags
Immunity Dysbiosis Covid-19 Monkey Virus Coronavirus SARS-CoV-2

en_view en_sources

    Created 08 June 2021
    Updated 30 March 2022

    About this article

    To know more about this topic.

    Main topic

    Covid-19

    Medical practice

    Pulmonology Gastroenterology

    Content type

    News
    Gastroenterology

    A pan-cancer mycobiome analysis reveals fungal involvement in gastrointestinal and lung tumours

    COMMENTED ARTICLE - ADULTS’ SECTION By Pr. Harry S...

    Find out more

    Artificial sweeteners, gut microbiota and metabolic health: an interaction requiring close examination

    By Pr. Karine ClémentSorbonne University, Inserm, U...

    Find out more

    Gut Microbiota #18

    By Pr. Satu PekkalaAcademy of Finland Research Fellow, Faculty of Sport and Health Sciences, Universi...

    Find out more

    Highlights of Gut Microbiota for Health - World Summit 2023

    By Dr. Nicolas BenechGastroenterology and hepatology, Microbiota Study Group, Hospices Civils de Lyon...

    Find out more

    Rural environment reduces allergic inflammation by modulating the gut microbiota

    Commented article - Children's section By Pr. Emma...

    Find out more

    Everything you need to know about Irritable Bowel Syndrome (IBS)

    Accrediting training, infographics, expert’s video,...

    Find out more

    Your IBS Diagnosis Check List

    How many patients suffering from gut disorder do you see per week? How many are diagnosed with Irrita...

    Find out more

    Human milk nutrient fortifiers alter the developing gastrointestinal microbiota of very-low-birth-weight infants

    Commented article - Children's section By Pr. Emma...

    Find out more

    Continue reading

    News
    Everything you need to know about the microbiota gut-brain axis
    22.05.2023

    Everything you need to know about the microbiota gut-brain axis

    Read the article
    SII, microbiote intestinal et dépression : un triptyque pour mieux comprendre la maladie
    27.07.2022

    IBS, gut microbiota and depression: a trio shedding light on the disease

    Read the article
    Actu PRO : Cancer du poumon : le microbiote intestinal signerait un stade précoce
    02.07.2020

    Gut microbiota could be an indicator of early-stage lung cancer

    Read the article
    Obesity: Is a bacterial fatty acid involved?
    15.05.2023

    Obesity: Is a bacterial fatty acid involved?

    Read the article
    Photo: Endométriose : une clé de sa progression au sein du microbiote intestinal
    09.05.2023

    Endometriosis: A key to its progression in the gut microbiota?

    Read the article
    16.11.2022

    Alcohol use disorders: in microbiota veritas?

    Read the article
    Photo: Atténuer la dénutrition avec des biotiques ?
    26.04.2023

    Mitigating malnutrition with biotics?

    Read the article
    25.04.2023

    F. prausnitzii : a biomarker of chronic fatigue syndrome

    Read the article
    What's worth reading about microbiota
    Follow us on Twitter
    Read our thematic folder
    The Janus face of Antibiotics: Life Savers & Microbiota Disrupters
    Microbiota 17 EN
    Check out our latest magazine
    The first 1000 days of life
    • Our publications
      • News
      • Microbiota Mag
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographics
      • IBS Diagnosis Check List
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube

    Lay public section

    Find here your dedicated section
    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology
    • English
    • Français
    • Español
    • Russian
    • Portuguese
    • Polish

    Browse the site

    • Our publications
      • News
      • Microbiota Mag
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographics
      • IBS Diagnosis Check List
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

    Lay public section

    Find here your dedicated section

    Redirection

    You are about to be redirected and leave our website

    • Be redirected
    • Stay on the Biocodex Microbiota Institute's website

    Stay with us !

    Join the Microbiota Community of HCPs and researchers and receive “Microbiota Digest” and "Microbiota Mag" to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    Explore

    Artificial sweeteners, gut microbiota and metabolic health: an interaction requiring close examination

    By Pr. Karine ClémentSorbonne University, Inserm, U...

    Find out more

    Urinary and Urethral Microbiota #18

    By Pr. Satu PekkalaAcademy of Finland Research Fellow, Faculty of Sport and Health Sciences, Universi...

    Find out more

    Vaginal Microbiota #18

    By Pr. Satu PekkalaAcademy of Finland Research Fellow, Faculty of Sport and Health Sciences, Universi...

    Find out more

    Stay updated

    Join the Microbiota Community of HCPs and researchers and receive “Microbiota Digest” and "Microbiota Mag" to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    • Our publications
      • News
      • Microbiota Mag
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographics
      • IBS Diagnosis Check List
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology

    Lay public section

    Find here your dedicated section

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

    © 2022 Biocodex. All rights reserved.

    • Cookies Policy
    • Data protection policy
    • GTU
    • Sitemap
    • Cookies settings
    Biocodex logo