Skip to main content
About the Institute
  • English
  • Français
  • Español
  • Portuguese
  • Polish

Breadcrumb

  1. Home
  2. Gastroenterology
  3. Microgravity, microbiota, and bone density
  • Our publications
    • News
    • Microbiota Mag
    • Thematic pages
    • Experts' point of view
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • About us
    • International Microbiota Observatory
    • Press room
    • Partnerships
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
  • Useful documents
    • How to talk about
    • Infographics
    • IBS Diagnosis Check List
    • Patients Stories

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube
    • Instagram
    • Bluesky

Lay public section

Find here your dedicated section
Gastroenterology
Gynecology
Pediatrics
General Medicine

Breadcrumb

  1. Home
  2. Gastroenterology
  3. Microgravity, microbiota, and bone density
Gastroenterology

Microgravity, microbiota, and bone density

Osteoporosis
Gastroenterology General Medicine

Loss of bone density is a well-known side-effect of microgravity for astronauts. According to a recent study on mice published in the journal Cell Reports, the microbiota may be able to counteract it.

Gastroenterology
Gynecology
Pediatrics
General Medicine
  • Our publications
    • News
    • Microbiota Mag
    • Thematic pages
    • Experts' point of view
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • About us
    • International Microbiota Observatory
    • Press room
    • Partnerships
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
  • Useful documents
    • How to talk about
    • Infographics
    • IBS Diagnosis Check List
    • Patients Stories

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube
    • Instagram
    • Bluesky

Lay public section

Find here your dedicated section

Sources

This article is based on scientific information

Sharing is caring

Your colleagues might be interested in this topic. Why not share it?

  • Facebook
  • Twitter
  • LinkedIn
  • Mail

About this article

Created 06 July 2023
Updated 10 February 2025

Though not as high-profile as space dog Laika, astronaut mice have taken part in a major Nasa research program.

The aim was to evaluate the effects of microgravity on bone homeostasis, with the ultimate goal of finding ways to mitigate the consequences of extended space travel. Spaceflight is associated with altered bone formation and increased bone resorption.

18.05.2022 Gut microbiota and vitamin D: a promising team in the fight against osteoporosis? Read more

Recent studies have established a link between changes in the gut microbiota and bone diseases such as osteoporosis via effects on the immune system, endocrine regulation, vitamin and nutrient deficiencies, and energy metabolism through short-chain fatty acids (SCFAs). To better understand the mechanisms involved in bone health, the Rodent Research 5 mission assessed the influence of microgravity on the gut and oral microbiota of 20 female mice that spent 4.5 weeks (10 rodents) or 9 weeks (10 rodents) in the International Space Station (ISS). This is the equivalent of several years in space for Neil Armstrong, since human life expectancy is 30 to 40 times longer than that of these small rodents.

Worldwide, osteoporosis causes more than 8.9 million fractures annually, resulting in an osteoporotic fracture every 3 seconds.

Effects of extended space travel

After 4.5 weeks in space, the rodents’ microbiota remained broadly similar in terms of diversity to that of 20 control rodents who stayed behind on Earth under identical conditions, except for microgravity. However, a more prolonged stay in the ISS (9 weeks) saw increased gut microbiota diversity, with a higher relative abundance of Firmicutes and a lower relative abundance of Bacteroidetes. More specifically, a longer stay in space led to an enrichment in Lactobacillus murinus (from the Firmicutes phylum) and Dorea sp. compared to the mice who had a 4.5-week stay. 
Moreover, compared with the rodents who remained on Earth, those that spent 9 weeks in space had enriched metabolic pathways associated with the production of lactic, malic and butyric acids, as well as glutathione and amino acids such as leucine and isoleucine.

1 in 3 women over age 50 years will experience osteoporotic fractures

1 in 5 men over age 50 years will experience osteoporotic fractures

Links with bone density

These metabolites are linked to bone mineral density in rodents. For example, glutathione promotes the survival of osteoblast precursors and thus bone regeneration, while leucine and isoleucine, two branched-chain amino acids, are actively imported into osteoblasts during chondrogenesis. 
From here it is only a short step to deducing that the microbiota and bodies of the mice are trying to compensate for bone loss during periods of microgravity. However, the researchers refuse to take this step until their hypotheses have been clearly confirmed by mechanistic studies. Nevertheless, the implications may be far-reaching: the identification of potential treatments, such as probiotic bacteria to help maintain bone health, may be beneficial to the health of astronauts in space, as well as that of ordinary earthlings suffering from osteopenia or osteoporosis.

Sources

Bedree JK, Kerns K, Chen T et al. Specific host metabolite and gut microbiome alterations are associated with bone loss during spaceflight. Cell Rep. 2023 Apr 10:112299.

Tags
Osteoporosis Space Microbiome Flora

    See also

    Gut microbiota and age-related frailty
    Photo : The gut microbiome and neurodegeneration The gut microbiome and neurodegeneration
    Created 06 July 2023
    Updated 10 February 2025

    About this article

    To know more about this topic.

    Main topic

    Osteoporosis

    Medical practice

    Gastroenterology General Medicine

    Content type

    News

    Continue reading

    News
    30.10.2024

    From gut to bone: how microbiota affects fragility fracture risk

    Read the article
    18.05.2022

    Gut microbiota and vitamin D: a promising team in the fight against osteoporosis?

    Read the article
    • Our publications
      • News
      • Microbiota Mag
      • Thematic pages
      • Experts' point of view
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • About us
      • International Microbiota Observatory
      • Press room
      • Partnerships
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
    • Useful documents
      • How to talk about
      • Infographics
      • IBS Diagnosis Check List
      • Patients Stories

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube
      • Instagram
      • Bluesky

    Lay public section

    Find here your dedicated section
    Gastroenterology
    Gynecology
    Pediatrics
    General Medicine
    • English
    • Français
    • Español
    • Portuguese
    • Polish

    Browse the site

    • Our publications
      • News
      • Microbiota Mag
      • Thematic pages
      • Experts' point of view
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • About us
      • International Microbiota Observatory
      • Press room
      • Partnerships
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
    • Useful documents
      • How to talk about
      • Infographics
      • IBS Diagnosis Check List
      • Patients Stories

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube
      • Instagram
      • Bluesky

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    General Medicine

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube
    • Instagram
    • Bluesky

    Lay public section

    Find here your dedicated section

    Redirection

    You are about to be redirected and leave our website

    • Be redirected
    • Stay on the Biocodex Microbiota Institute's website

    Stay with us !

    Join the Microbiota Community of HCPs and researchers and receive “Microbiota Digest” and "Microbiota Mag" to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    Explore

    14.05.2025

    Towards worldwide redefinition of healthy vaginal microbiota

    Read the article
    07.05.2025

    The microbial-metabolic nexus in colon cancer

    Read the article
    02.05.2025

    A new lens on chlamydia: beyond behavior, into the microbiome

    Read the article

    Stay updated

    Join the Microbiota Community of HCPs and researchers and receive “Microbiota Digest” and "Microbiota Mag" to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    • Our publications
      • News
      • Microbiota Mag
      • Thematic pages
      • Experts' point of view
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • About us
      • International Microbiota Observatory
      • Press room
      • Partnerships
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
    • Useful documents
      • How to talk about
      • Infographics
      • IBS Diagnosis Check List
      • Patients Stories

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube
      • Instagram
      • Bluesky

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    General Medicine

    Lay public section

    Find here your dedicated section

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube
    • Instagram
    • Bluesky

    © 2025 Biocodex. All rights reserved.

    • Legal notice
    • GTU
    • Data protection policy
    • Sitemap
    • Cookies settings
    • Digital accessibility : partially compliant
    Biocodex logo