Skip to main content
About the Institute
  • English
  • Français
  • Español
  • Russian

Breadcrumb

  1. Home
  2. Microbiota 8 - October 2019
  3. Gut microbiota and age-related frailty
  • Our publications
    • News
    • Microbiota Mag
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • Partnerships
    • Press room
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
    • Xpeer App
  • Useful documents
    • Infographic
    About the Institute

    Join the microbiota community

    • Facebook
    • Twitter
    • YouTube

Lay public section

Find here your dedicated section
Gastroenterology
Gynecology
Pediatrics
Dermatology

Breadcrumb

  1. Home
  2. Microbiota 8 - October 2019
  3. Gut microbiota and age-related frailty
Gastroenterology

Gut microbiota and age-related frailty

Elderly health

Press review

By Pr. Markku Voutilainen
Turku University Faculty of Medicine; Turku University Hospital, Department of Gastroenterology, Turku, Finland

Gastroenterology
Gynecology
Pediatrics
Dermatology
  • Our publications
    • News
    • Microbiota Mag
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • Partnerships
    • Press room
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
    • Xpeer App
  • Useful documents
    • Infographic
    About the Institute

    Join the microbiota community

    • Facebook
    • Twitter
    • YouTube

Lay public section

Find here your dedicated section

Sources

This article is based on scientific information

Sharing is caring

Your colleagues might be interested in this topic. Why not share it?

  • Facebook
  • Twitter
  • Mail

Sections

About this article

Created 25 August 2021
Updated 04 November 2021

The authors have reviewed the role of gut microbiota and dysbiosis in the development of age-related frailty.[1] The physical manifestations of frailty are weight loss, muscle weakness, fatigue, sedendary lifestyle and slow gai. Muscle weakness is due to sarcopenia characterized by loss of both muscle mass and function, e.g. strength and power. The prevalence of sarcopenia is 5–13% and 11–50% in persons aged 60–70 and over 80 years, respectively.

Aging is characterized by increased inflammatory responses, endothelial dysfunction, changes of the immune system an increased nitrosative stress. With increasing age, the gut microbiome shows decreased biodiversity and increased number of pathogens. The changes are typical for persons aged over 65 years, and are attributable to altered diet composition caused by reduction in appetite, loss of dentition and chewing efficiency, swallowing disorders and malabsorption. Changes in microbiota are not uniform, but may be associated with geographical location, habitat, lifestyle (smoking, alcohol consumption), physical activity, the use of antibiotics and other medication as well as genetic factors. The most typical age-related microbiome changes are the diminution of butyrate-producing bacteria (Bifidobacteria, Firmicutes) and the increase of Bacteroides. There is a tendency to increasing number of opportunistic pathogens that may increase gut permeability. However, interindividual heterogeneity is wide.

Dysbiosis is associated with reduced muscle protein synthesis (anabolic resistance) leading to sarcopenia. The reduction of the short-chain fatty acids may have a central role in the disordered muscle energy and protein metabolism. Dysbiosis may also reduce the bioavailability of dietary amino acids and disturb vitamin metabolism of skeletal muscle cells. The main mechanisms of dysbiosis-induced sarcopenia are anabolic resistance, inflammation, disturbed mitochondrial metabolism, oxidative stress, and insulin resistance.

Deficient nutrition and physical inactivity have central role in the pathogenesis of sarcopenia and they also have major impact on gut microbiota. Conversely, gut dysbiosis may modulate systemic inflammation, muscle protein synthesis, insulin sensitivity and energy metabolism. At present, there is no evidence of specific microbiota composition of sarcopenic patients. The present review, however, supports the concept that gut microbiota mediates the effects of nutrition on muscle cells (“gut-muscle axis”).

Sources

1 Casati M, Ferri E, Azzolono D, et al. Gut microbiota and physical frailty through the mediation of sarcopenia. Exp Gerontol 2019 ; 124 : 110639.

Tags
Gastroenterology Geriatrics

en_view en_sources

    Focus
    Microbiota 8 - October 2019
    • Overview
      • Microbiota and metabolic diseases
    • Commented articles
      • Parkinson’s disease: discovery and inhibition of levodopa metabolism by gut bacteria
      • Clinical and biological predictors of response to standardized pediatric colitis therapy: a prospective multicenter study
    • Congress review
      • Focus on the 4th biennial meeting of the ESNM
      • ESPGHAN: main contributions on intestinal microbiota in children
    • Press review
      • Gut microbiota and age-related frailty
      • The mediterranean diet, gut microbiota and noncommunicable diseases
      • The gut microbiome and chronic inflammatory diseases
    Created 25 August 2021
    Updated 04 November 2021

    About this article

    To know more about this topic.

    Main topic

    Elderly health

    Content type

    Press review
    ESPGHAN: main contributions on intestinal microbiota in children
    The mediterranean diet, gut microbiota and noncommunicable diseases
    Focus

    Microbiota 8 - October 2019

    Overview

    Microbiota and metabolic diseases

    Commented articles

    Parkinson’s disease: discovery and inhibition of levodopa metabolism by gut bacteria Clinical and biological predictors of response to standardized pediatric colitis therapy: a prospective multicenter study

    Congress review

    Focus on the 4th biennial meeting of the ESNM ESPGHAN: main contributions on intestinal microbiota in children

    Press review

    Gut microbiota and age-related frailty The mediterranean diet, gut microbiota and noncommunicable diseases The gut microbiome and chronic inflammatory diseases
    Gastroenterology
    22.11.2021

    Irritable bowel syndrome: is fecal microbiota transplantation effective in the long term?

    Read the article
    Cancer du pancréas : un diagnostic précoce non invasif grâce au microbiote fécal ?
    16.06.2022

    Pancreatic cancer: non-invasive early diagnosis thanks to the fecal microbiota?

    Read the article
    Photo: Régime méditerranéen « vert » : quels liens entre santé cardiométabolique et microbiote intestinal ?
    10.06.2022

    Green Mediterranean diet: what links between cardiometabolic health and gut microbiota?

    Read the article
    Immune checkpoint inhibitor (ICI) efficacy: the right dose of bacteria
    02.06.2022

    Immune checkpoint inhibitor (ICI) efficacy: the right dose of bacteria

    Read the article
    18.05.2022

    Gut microbiota and vitamin D: a promising team in the fight against osteoporosis?

    Read the article
    Photo: Neonatal sepsis: the microbiota pays a heavy price for antibiotic use
    09.05.2022

    Neonatal sepsis: the microbiota pays a heavy price for antibiotic use

    Read the article
    26.04.2022

    Severe obesity: the vicious circle of biotin metabolism

    Read the article
    22.04.2022

    SCFAs: new intestinal markers of Parkinson’s disease?

    Read the article
    What's worth reading about microbiota
    Follow us on Twitter
    Read our thematic folder
    The Janus face of Antibiotics: Life Savers & Microbiota Disrupters
    NL13_cover
    Check out latest newsletter
    IBS, Microbiota & Covid-19
    • Our publications
      • News
      • Microbiota Mag
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographic
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • YouTube

    Lay public section

    Find here your dedicated section
    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology
    • English
    • Français
    • Español
    • Russian

    Browse the site

    • Our publications
      • News
      • Microbiota Mag
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographic
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • YouTube

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology

    Join the microbiota community

    • Facebook
    • Twitter
    • YouTube

    Lay public section

    Find here your dedicated section

    Redirection

    You are about to be redirected and leave our website

    • Be redirected
    • Stay on the Biocodex Microbiota Institute's website

    Stay with us !

    Join the Microbiota Community of HCPs and researchers and receive once a month the “Microbiota Digest” to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    Explore

    Photo: Postménopause : l'action bénéfique de l'estradiol sur le microbiote vaginal
    22.06.2022

    Postmenopause: the beneficial action of estradiol on the vaginal microbiota

    Read the article
    WMD_Foundation KOL USA 2018
    17.06.2022

    Dr. Yang (USA winner 2018): Gut microbiota & gut brain axis

    Read the article
    WMD_Foundation KOL USA 2017
    17.06.2022

    Dr. Singh (USA winner 2017): Microbiota & polyphenols

    Read the article

    Stay updated

    Join the Microbiota Community of HCPs and researchers and receive once a month the “Microbiota Digest” to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    • Our publications
      • News
      • Microbiota Mag
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographic
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • YouTube

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology

    Lay public section

    Find here your dedicated section

    Join the microbiota community

    • Facebook
    • Twitter
    • YouTube

    © 2022 Biocodex. All rights reserved.

    • Cookies Policy
    • Data protection policy
    • GTU
    • Sitemap
    • Cookies settings
    Biocodex logo