Chronic fatigue syndrome is associated with intestinal dysbiosis


The intestinal microbiota could play a role in chronic fatigue syndrome and influence its severity. This disorder is characterized by persistent fatigue not relieved by rest. A study published in Microbiome shows that it is associated with dysbiosis and metabolic disruptions of the intestinal flora. The authors analyzed its composition in 50 patients and the same number of control subjects. They observed substantial abnormalities in the patients, especially those who also had irritable bowel syndrome, which is one of the commonly encountered comorbidities. The dysbiosis observed was marked by an increase in the quantity of Alistipes and a decrease in Faecalibacterium. The authors also identified dysbiosis specific to the chronic fatigue syndrome and independent of the irritable bowel syndrome: increase in the quantity of unclassified Bacteroides and reduction in the species Bacteroides vulgatus associated with a reduction in the biosynthesis of unsaturated fatty acids. This study could eventually help improve the diagnosis of this complex disorder, and even provide therapeutic approaches.


Nagy-Szakal D. et al. Fecal metagenomic profiles in subgroups of patients with myalgic encephalomyelitis/chronic fatigue syndrome. Microbiome. 2017 Apr 26;5(1):44.