Skip to main content
About the Institute
  • English
  • Français
  • Español
  • Russian
  • Portuguese

Breadcrumb

  1. Home
  2. Gastroenterology
  3. Is Sjögren syndrome caused by an oral dysbiosis?
  • Our publications
    • News
    • Microbiota Mag
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • Partnerships
    • Press room
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
    • Xpeer App
  • Useful documents
    • Infographic
    About the Institute

    Join the microbiota community

    • Facebook
    • Twitter
    • YouTube

Lay public section

Find here your dedicated section
Gastroenterology
Gynecology
Pediatrics
Dermatology

Breadcrumb

  1. Home
  2. Gastroenterology
  3. Is Sjögren syndrome caused by an oral dysbiosis?
Gastroenterology

Is Sjögren syndrome caused by an oral dysbiosis?

Dry syndrome
Neurology Gastroenterology

A dysbiosis of the oral microbiota may be involved in the pathogenesis of Sjögren syndrome, particularly in the phenotypic change in epithelial cells of the salivary glands and in the inflammation of the glands themselves.

Gastroenterology
Gynecology
Pediatrics
Dermatology
  • Our publications
    • News
    • Microbiota Mag
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • Partnerships
    • Press room
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
    • Xpeer App
  • Useful documents
    • Infographic
    About the Institute

    Join the microbiota community

    • Facebook
    • Twitter
    • YouTube

Lay public section

Find here your dedicated section

Sources

This article is based on scientific information

Sharing is caring

Your colleagues might be interested in this topic. Why not share it?

  • Facebook
  • Twitter
  • Mail
Photo : Is Sjögren syndrome caused by an oral dysbiosis?

About this article

Created 16 June 2020
Updated 06 October 2021

Sjӧgren syndrome (SS) is an autoimmune epithelitis characterized by dry mouth and dry eyes. The epithelial cells in the salivary glands act both as agents and targets by transforming into cells capable of activating the immune system (T cells, dendritic cells, then B cells) and synthesizing chemokines that cause lymphocytic infiltration. The inflammation of the salivary glands associated with these infiltrates is one of the diagnostic criteria for SS. However, it is not yet known what causes the disease. Among the suspects is a dysbiosis of the oral microbiota, already implicated in several autoimmune diseases (systemic lupus, Crohn’s disease, rheumatoid arthritis). The study described below sought to characterize the oral microbiota of patients with SS and to identify whether it had any role in the onset of the disease.

Dysbiosis of the oral microbiota

Oral bacterial communities were sampled via full mouth washing in 25 patients with a primary form of SS (17 with dry mouth and 8 without) and in 25 control subjects (11 with dry mouth and 14 without). These subgroups were selected in order to characterize the changes in the oral microbiota associated with SS, while controlling for the effects of dry mouth. Compared to that of control subjects, the oral microbiota of the SS patients had a higher bacterial load and, in correlation, was more diverse, with bacterial diversity even more pronounced in those not suffering from dry mouth.

The role of Prevotella melaninogenica

In order to assess whether bacterial species associated with the syndrome act as pathogens, the researchers tested in vitro three of the oral bacteria species that signal dysbiosis in SS patients, selecting those that express porins (proteins that allow membrane exchanges). Of these species, P. melaninogenica is able to induce functional (secretion of interferon λ by tumor cells, causing inflammation) and phenotypic (presentation of antigens) changes in the epithelial cells of the salivary glands. The question remained as to whether this bacterium could reach the salivary glands, and this was confirmed by a series of biopsies revealing its presence in salivary ductal cells and infiltration areas. This is thought to result from a rupture of the epithelial barrier due to inflammation and/or fibrosis. In this first scenario, the bacterial infection aggravates the inflammation and the deregulation already underway within the epithelial cells of the salivary glands. However, since the bacterium is also present in non-inflamed areas, another scenario is also possible, in which bacterial infection precedes lymphocyte infiltration. In short, a dysbiosis of the oral microbiota may initiate deregulation of the epithelial cells in the salivary glands. This would lead to a bacterial invasion of the ductal cells able to fuel the inflammation by itself.

Sources

Alam J, Lee A, Lee J et al. Dysbiotic oral microbiota and infected salivary glands in Sjögren's syndrome. PLoS One. 2020 Mar 24;15(3):e0230667.

Tags
Dysbiosis Sjögren Infection Dry mouth Salivary glands Mouth

en_view en_sources

    Created 16 June 2020
    Updated 06 October 2021

    About this article

    To know more about this topic.

    Main topic

    Dry syndrome

    Medical practice

    Neurology Gastroenterology

    Content type

    News
    Gastroenterology

    The blue poop challenge: a reliable method to evaluate gut transit?

    By Pr. Gianluca Ianiro Gastroenterology Department, Fondazione Policlinico Universitario Agostino Gemelli- ...

    Find out more

    New perspectives in autism: the role of microbiota in social communication

    Overview By Dr. Vincent Trebossen Child and Adolescent P...

    Find out more

    Gut microbiota #15

    By Pr. Markku Voutilainen Turku University Faculty of Medicine; Turku University Hospital, Department of Ga...

    Find out more

    Microbiome topics at gastro 2021

    Congress Review By Pr. Eamonn M M Quigley Lynda K and David M Underwood Center for Digestive Disorders, Di...

    Find out more

    Commensal clostridiales strains mediate effective anti-cancer immune response against solid tumours

    Commented articles - Adults' section By Pr. Harry Sokol ...

    Find out more

    Microbiota in covid-19 pandemic

    Overview By Pr. Conceição Calhau NOVA Medical School, New University of Lisbon, Portugal By Pr. Pedro Povo...

    Find out more

    Association between fungal dysbiosis and environment

    The fungal portion of the gut microbiota (or mycobiota) has been much less studied than the bacterial porti...

    Find out more

    From diarrhea to chronic diseases: the well-documented consequences of antibiotic-related gut microbiota dysbiosis

    Antibiotic treatment may sometimes take place without any...

    Find out more

    Continue reading

    News
    22.11.2021

    Irritable bowel syndrome: is fecal microbiota transplantation effective in the long term?

    Read the article
    Cancer du pancréas : un diagnostic précoce non invasif grâce au microbiote fécal ?
    16.06.2022

    Pancreatic cancer: non-invasive early diagnosis thanks to the fecal microbiota?

    Read the article
    Photo: Régime méditerranéen « vert » : quels liens entre santé cardiométabolique et microbiote intestinal ?
    10.06.2022

    Green Mediterranean diet: what links between cardiometabolic health and gut microbiota?

    Read the article
    Immune checkpoint inhibitor (ICI) efficacy: the right dose of bacteria
    02.06.2022

    Immune checkpoint inhibitor (ICI) efficacy: the right dose of bacteria

    Read the article
    18.05.2022

    Gut microbiota and vitamin D: a promising team in the fight against osteoporosis?

    Read the article
    Photo: Neonatal sepsis: the microbiota pays a heavy price for antibiotic use
    09.05.2022

    Neonatal sepsis: the microbiota pays a heavy price for antibiotic use

    Read the article
    26.04.2022

    Severe obesity: the vicious circle of biotin metabolism

    Read the article
    22.04.2022

    SCFAs: new intestinal markers of Parkinson’s disease?

    Read the article
    What's worth reading about microbiota
    Follow us on Twitter
    Read our thematic folder
    The Janus face of Antibiotics: Life Savers & Microbiota Disrupters
    NL13_cover
    Check out latest newsletter
    IBS, Microbiota & Covid-19
    • Our publications
      • News
      • Microbiota Mag
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographic
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • YouTube

    Lay public section

    Find here your dedicated section
    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology
    • English
    • Français
    • Español
    • Russian
    • Portuguese

    Browse the site

    • Our publications
      • News
      • Microbiota Mag
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographic
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • YouTube

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology

    Join the microbiota community

    • Facebook
    • Twitter
    • YouTube

    Lay public section

    Find here your dedicated section

    Redirection

    You are about to be redirected and leave our website

    • Be redirected
    • Stay on the Biocodex Microbiota Institute's website

    Stay with us !

    Join the Microbiota Community of HCPs and researchers and receive once a month the “Microbiota Digest” to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    Explore

    Photo: Postménopause : l'action bénéfique de l'estradiol sur le microbiote vaginal
    22.06.2022

    Postmenopause: the beneficial action of estradiol on the vaginal microbiota

    Read the article
    WMD_Foundation KOL USA 2018
    17.06.2022

    Dr. Yang (USA winner 2018): Gut microbiota & gut brain axis

    Read the article
    WMD_Foundation KOL USA 2017
    17.06.2022

    Dr. Singh (USA winner 2017): Microbiota & polyphenols

    Read the article

    Stay updated

    Join the Microbiota Community of HCPs and researchers and receive once a month the “Microbiota Digest” to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    • Our publications
      • News
      • Microbiota Mag
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographic
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • YouTube

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology

    Lay public section

    Find here your dedicated section

    Join the microbiota community

    • Facebook
    • Twitter
    • YouTube

    © 2022 Biocodex. All rights reserved.

    • Cookies Policy
    • Data protection policy
    • GTU
    • Sitemap
    • Cookies settings
    Biocodex logo