Skip to main content
About the Institute
  • English
  • Français
  • Español
  • Russian
  • Portuguese
  • Polish
  • Turkish

Breadcrumb

  1. Home
  2. Pediatrics
  3. Can fecal transplantation restore the microbiota of Caesarean-born infants?
  • Our publications
    • News
    • Microbiota Mag
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • Partnerships
    • Press room
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
    • Xpeer App
  • Useful documents
    • Infographic
    About the Institute

    Join the microbiota community

    • Facebook
    • Twitter
    • YouTube

Lay public section

Find here your dedicated section
Gastroenterology
Gynecology
Pediatrics
Dermatology

Breadcrumb

  1. Home
  2. Pediatrics
  3. Can fecal transplantation restore the microbiota of Caesarean-born infants?
Pediatrics

Can fecal transplantation restore the microbiota of Caesarean-born infants?

Baby health
Gynecology Pediatrics Gastroenterology

A new study published in Cell shows that the gut microbiota of infants born by Caesarean section can be restored through a fecal microbiota transplant from their mothers. The result is a gut microbiota resembling that of vaginally born infants.

Gastroenterology
Gynecology
Pediatrics
Dermatology
  • Our publications
    • News
    • Microbiota Mag
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • Partnerships
    • Press room
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
    • Xpeer App
  • Useful documents
    • Infographic
    About the Institute

    Join the microbiota community

    • Facebook
    • Twitter
    • YouTube

Lay public section

Find here your dedicated section

Sources

This article is based on scientific information

Sharing is caring

Your colleagues might be interested in this topic. Why not share it?

  • Facebook
  • Twitter
  • Mail
Actu PRO : La transplantation fécale pour restaurer le microbiote des bébés nés par césarienne ?

About this article

Created 23 February 2021
Updated 06 October 2021

The gut microbiota of infants born by Caesarean section (CS) differs from that of infants born vaginally since CS-born infants are not exposed to maternal microbes during delivery. Some studies report that CS may have short- and long-term consequences for infants’ health, including an increased risk of chronic immune diseases (asthma, allergies, etc.), although this claim remains controversial. A Finnish team has evaluated the efficacy and safety of fecal microbiota transplant (FMT) as a means of restoring the gut microbiota of babies born by CS.

Strict clinical protocol

Stool samples were collected from 17 mothers three weeks before the scheduled CS. A total of 7 women were selected following rigorous screening for pathogens in their stool. Within two hours of birth by CS, each baby received via bottle an FMT from its mother containing approximately 106-107 viable bacterial cells (1 mL of maternal stool diluted in 4 mL of breast milk). The gut microbiota and health status of each infant were evaluated at birth, for two days in the maternity ward, then every week for one month, and finally at three months. The composition of their gut microbiota was analyzed via 16S rRNA sequencing, then compared to that of 82 babies born vaginally or by CS without FMT.

Promising results

FMT did not give rise to any adverse effects or complications in the infants during the study period. The gut microbiota of FMT-treated CS infants and infants born vaginally differed in the first few days, then became similar after one week, but remained quite distinct from that of untreated CS-born infants. FMT appears to correct the bacterial signature of CS by bringing the abundance of Bacteroidales and Bifidobacteriales in line with that of vaginally born infants. In addition, the presence of potential pathogens was lower at one week and three months in FMT-treated CS infants compared to untreated CS-born infants. This first proof-of-concept study shows the safety and potential efficacy of FMT as a means of restoring the gut microbiota of infants born by CS. Larger-scale studies are required, but these results provide additional evidence of the importance of natural microbiota transfer from mother to child during childbirth.

Sources

Korpela K, Helve O, Kolho KL, et al. Maternal Fecal Microbiota Transplantation in Cesarean-Born Infants Rapidly Restores Normal Gut Microbial Development: A Proof-of-Concept Study. Cell. 2020 Oct 15;183(2):324-334.e5

Tags
Delivery Fecal Transplant Fecal transplants FMT C-section Vaginal delivery

en_view en_sources

    Created 23 February 2021
    Updated 06 October 2021

    About this article

    To know more about this topic.

    Main topic

    Baby health

    Medical practice

    Gynecology Pediatrics Gastroenterology

    Content type

    News

    Continue reading

    News
    Photo: Postménopause : l'action bénéfique de l'estradiol sur le microbiote vaginal
    22.06.2022

    Postmenopause: the beneficial action of estradiol on the vaginal microbiota

    Read the article
    22.11.2021

    Irritable bowel syndrome: is fecal microbiota transplantation effective in the long term?

    Read the article
    WMD_Foundation KOL Mexico 2019
    10.06.2022

    Pr. Moisés Alvarez (Mexican winner 2019): Microbiota & colorectal cancer

    Read the article
    WMD_Foundation KOL USA 2017
    17.06.2022

    Dr. Singh (USA winner 2017): Microbiota & polyphenols

    Read the article
    WMD_Foundation KOL USA 2021
    16.06.2022

    Dr. Queen (USA winner 2020): Microbiota & colorectal cancer

    Read the article
    WMD_Foundation KOL USA 2022
    16.06.2022

    Dr. Brown (USA winner 2021): Microbiota & respiratory syncitial virus infection

    Read the article
    31.05.2022

    Pr. Maslennikov (Russian winner 2019): Probiotics & cirrhosis

    Read the article
    WMD_Foundation KOL Russia 2020
    15.06.2022

    Pr. Shifrin (Russian winner 2020): Gut microbiota & antibiotics

    Read the article
    What's worth reading about microbiota
    Follow us on Twitter
    Read our thematic folder
    The Janus face of Antibiotics: Life Savers & Microbiota Disrupters
    NL13_cover
    Check out latest newsletter
    IBS, Microbiota & Covid-19
    • Our publications
      • News
      • Microbiota Mag
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographic
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • YouTube

    Lay public section

    Find here your dedicated section
    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology
    • English
    • Français
    • Español
    • Russian
    • Portuguese
    • Polish
    • Turkish

    Browse the site

    • Our publications
      • News
      • Microbiota Mag
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographic
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • YouTube

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology

    Join the microbiota community

    • Facebook
    • Twitter
    • YouTube

    Lay public section

    Find here your dedicated section

    Redirection

    You are about to be redirected and leave our website

    • Be redirected
    • Stay on the Biocodex Microbiota Institute's website

    Stay with us !

    Join the Microbiota Community of HCPs and researchers and receive once a month the “Microbiota Digest” to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    Explore

    Photo: Postménopause : l'action bénéfique de l'estradiol sur le microbiote vaginal
    22.06.2022

    Postmenopause: the beneficial action of estradiol on the vaginal microbiota

    Read the article
    WMD_Foundation KOL USA 2018
    17.06.2022

    Dr. Yang (USA winner 2018): Gut microbiota & gut brain axis

    Read the article
    WMD_Foundation KOL USA 2017
    17.06.2022

    Dr. Singh (USA winner 2017): Microbiota & polyphenols

    Read the article

    Stay updated

    Join the Microbiota Community of HCPs and researchers and receive once a month the “Microbiota Digest” to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    • Our publications
      • News
      • Microbiota Mag
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographic
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • YouTube

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology

    Lay public section

    Find here your dedicated section

    Join the microbiota community

    • Facebook
    • Twitter
    • YouTube

    © 2022 Biocodex. All rights reserved.

    • Cookies Policy
    • Data protection policy
    • GTU
    • Sitemap
    • Cookies settings
    Biocodex logo