Skip to main content
About the Institute
  • English
  • Français
  • Español
  • Russian
  • Portuguese
  • Polish

Breadcrumb

  1. Home
  2. Gynecology
  3. Peripartum prophylactic antibiotic therapy decreases bifidobacterium levels in breast milk
  • Our publications
    • News
    • Microbiota Mag
    • Thematic pages
    • Experts' point of view
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • About us
    • International Microbiota Observatory
    • Press room
    • Partnerships
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
  • Useful documents
    • How to talk about
    • Infographics
    • IBS Diagnosis Check List
    • Patients Stories

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube
    • Instagram
    • Bluesky

Lay public section

Find here your dedicated section
Gastroenterology
Gynecology
Pediatrics
General Medicine

Breadcrumb

  1. Home
  2. Gynecology
  3. Peripartum prophylactic antibiotic therapy decreases bifidobacterium levels in breast milk
Gynecology

Peripartum prophylactic antibiotic therapy decreases bifidobacterium levels in breast milk

Antibiotics
Gastroenterology

Peripartum preventive antibiotic therapy changes the bacterial composition of breast milk. Levels of Bifidobacterium, bacteria that are beneficial to the development of newborns, are significantly reduced in the days following delivery.

Gastroenterology
Gynecology
Pediatrics
General Medicine
  • Our publications
    • News
    • Microbiota Mag
    • Thematic pages
    • Experts' point of view
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • About us
    • International Microbiota Observatory
    • Press room
    • Partnerships
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
  • Useful documents
    • How to talk about
    • Infographics
    • IBS Diagnosis Check List
    • Patients Stories

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube
    • Instagram
    • Bluesky

Lay public section

Find here your dedicated section

Sources

This article is based on scientific information

Sharing is caring

Your colleagues might be interested in this topic. Why not share it?

  • Facebook
  • Twitter
  • LinkedIn
  • Mail
Actu PRO : Une antibiothérapie prophylactique péri-partum appauvrit le lait maternel en Bifidobacterium

About this article

Created 12 March 2019
Updated 30 October 2023

Prophylactic antibiotic therapy is necessary to reduce the risks of peripartum infections, which are the cause of 10% of maternal deaths and are associated to the death of nearly 1 million of newborns every year, according to the (sidenote: WHO recommendations for prevention and treatment of maternal peripartum infections- 2015 ) . However, these treatments are associated with adverse effects, including changes in the maternal microbiota that are likely to impact the child’s early colonization. This led a Brazilian team to study changes in breast milk bacterial populations, while focusing on bacteria from the Bifidobacterium genus. The main representatives of this genus (B. breve, B. adolescentis, B. bifidum, B. longum, and B. dentium in breast milk) are known for their beneficial effects on humans, especially through the production of short-chain fatty acids.

Significant decrease in Bifidobacterium on Day 7

Researchers compared samples of milk from 55 women who gave birth vaginally: 21 were preventively treated with broad-spectrum antibiotics (cefazolin, penicillin or clindamycin) and 34 treatment-naive women. Total bacterial concentration as well as detailed count of Bifidobacterium were determined by qPCR in samples taken on Days 7±3 and 30±4. The results did not show significant differences between the study groups in the total number of bacteria. An explanation for this finding might be the repopulation by bacteria that are resistant to the antibiotics used in the study. On the contrary, a significant decrease in levels of Bifidobacterium is observed in the milk of women treated prophylactically. This dysbiosis is at its peak on Day 7±3 but returns to normal over time and is not noticeable after one month.

Hailed as one of the greatest medical advances of the 20th century, antibiotics have saved millions of lives. But they also have an impact on our microbiota by inducing a dysbiosis. Let’s take a look at this ambivalence role:

The ambivalent role of antibiotics

By destroying the bacteria responsible for infection, antibiotics can also lead…

Dysbiosis gradual improvement: hypotheses

Researchers suggest a likely recolonization from the gut microbiota, trough the endogenous entero‑mammary pathway involving maternal dendritic cells able to capture commensal bacteria in the lumen. Other hypothesis: oligosaccharides present in breast milk might act as a substrate and promote Bifidobacterium growth. All we can say for sure is that if the mother is breastfeeding, peripartum prophylactic antibiotic therapy reduces the supply of beneficial bacteria to the child. This initial observation requires us to detail the impact of this temporary deficit on the development of the newborn’s gut microbiota and correlated functions, especially immune and inflammatory functions.

What is the World AMR Awareness Week?

Each year, since 2015, the WHO organizes the World AMR Awareness Week (WAAW), which aims to increase awareness of global antimicrobial resistance.
Held on 18-24 November, this campaign encourages the general public, healthcare professionals and decision-makers to use antimicrobials carefully, to prevent the further emergence of antimicrobial resistance.

Sources

Padilha M, Iaucci J, Cabral V et al. Maternal antibiotic prophylaxis affects Bifidobacterium spp. counts in the human milk, during the first week after delivery. Benef Microbes. 2019 Mar 13;10(2):155-163.

Tags
Antibiotics Delivery Breastfeeding WAAW World Antimicrobial Awareness Week Public health Microbiome Flora

    See also

    Photo: WAAW 2022 (HCPs) Microbiota at the forefront of antibiotic resistance
    Actu GP : Lait maternel : l’alimentation pendant la grossesse est capitale Breast milk: diet during pregnancy is crucial
    Created 12 March 2019
    Updated 30 October 2023

    About this article

    To know more about this topic.

    Main topic

    Antibiotics

    Medical practice

    Gastroenterology

    Content type

    News

    Continue reading

    News
    26.10.2023

    Can antibiotics promote the growth of harmful bacteria in the gut?

    Read the article
    21.02.2022

    Phage therapy for multidrug-resistant infections?

    Read the article

    Probiotics: what exactly are we talking about?

    From the Latin pro and Greek bios meaning “for life”, the term “probiotic” was suggested over 60 year...

    Find out more

    How do you choose a probiotic for your patient?

    Faced with a plethora of products on the market, it's not always easy for health professionals to sug...

    Find out more
    Intestinal bacteria, illustration.
    24.08.2023

    Everything you need to know about probiotics

    Read the article
    28.08.2024

    Precision molecule against Gram-negative infections: a new era of antibiotics that spare the gut microbiota

    Read the article
    12.11.2024

    Human microbiomes: reservoirs of antimicrobial peptides

    Read the article
    25.10.2024

    Antibiotic resistance: discovery of a million antimicrobial peptides

    Read the article
    • Our publications
      • News
      • Microbiota Mag
      • Thematic pages
      • Experts' point of view
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • About us
      • International Microbiota Observatory
      • Press room
      • Partnerships
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
    • Useful documents
      • How to talk about
      • Infographics
      • IBS Diagnosis Check List
      • Patients Stories

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube
      • Instagram
      • Bluesky

    Lay public section

    Find here your dedicated section
    Gastroenterology
    Gynecology
    Pediatrics
    General Medicine
    • English
    • Français
    • Español
    • Russian
    • Portuguese
    • Polish

    Browse the site

    • Our publications
      • News
      • Microbiota Mag
      • Thematic pages
      • Experts' point of view
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • About us
      • International Microbiota Observatory
      • Press room
      • Partnerships
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
    • Useful documents
      • How to talk about
      • Infographics
      • IBS Diagnosis Check List
      • Patients Stories

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube
      • Instagram
      • Bluesky

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    General Medicine

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube
    • Instagram
    • Bluesky

    Lay public section

    Find here your dedicated section

    Redirection

    You are about to be redirected and leave our website

    • Be redirected
    • Stay on the Biocodex Microbiota Institute's website

    Stay with us !

    Join the Microbiota Community of HCPs and researchers and receive “Microbiota Digest” and "Microbiota Mag" to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    Explore

    14.05.2025

    Towards worldwide redefinition of healthy vaginal microbiota

    Read the article
    07.05.2025

    The microbial-metabolic nexus in colon cancer

    Read the article
    02.05.2025

    A new lens on chlamydia: beyond behavior, into the microbiome

    Read the article

    Stay updated

    Join the Microbiota Community of HCPs and researchers and receive “Microbiota Digest” and "Microbiota Mag" to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    • Our publications
      • News
      • Microbiota Mag
      • Thematic pages
      • Experts' point of view
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • About us
      • International Microbiota Observatory
      • Press room
      • Partnerships
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
    • Useful documents
      • How to talk about
      • Infographics
      • IBS Diagnosis Check List
      • Patients Stories

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube
      • Instagram
      • Bluesky

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    General Medicine

    Lay public section

    Find here your dedicated section

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube
    • Instagram
    • Bluesky

    © 2025 Biocodex. All rights reserved.

    • Legal notice
    • GTU
    • Data protection policy
    • Sitemap
    • Cookies settings
    • Digital accessibility : partially compliant
    Biocodex logo