Skip to main content
  • English
  • Français
  • Español
  • Russian

Breadcrumb

  1. Home
  2. Gastroenterology
  3. Steatohepatitis: viral microbiota also involved
  • Our publications
    • News
    • Microbiota Mag
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • Partnerships
    • Press room
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
    • Xpeer App
  • Useful documents
    • Infographic
    About the Institute

    Join the microbiota community

    • Facebook
    • Twitter
    • YouTube

Lay public section

Find here your dedicated section
Gastroenterology
Gynecology
Pediatrics
Dermatology

Breadcrumb

  1. Home
  2. Gastroenterology
  3. Steatohepatitis: viral microbiota also involved
Gastroenterology

Steatohepatitis: viral microbiota also involved

Hepatitis
Hepatology Gastroenterology

In addition to the bacterial changes previously identified in the gut microbiota of patients developing steatohepatitis, a study has also pointed to changes in the viral population. This may make it possible to identify and classify patients according to severity.

Gastroenterology
Gynecology
Pediatrics
Dermatology
  • Our publications
    • News
    • Microbiota Mag
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • Partnerships
    • Press room
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
    • Xpeer App
  • Useful documents
    • Infographic
    About the Institute

    Join the microbiota community

    • Facebook
    • Twitter
    • YouTube

Lay public section

Find here your dedicated section

Sources

This article is based on scientific information

Sharing is caring

Your colleagues might be interested in this topic. Why not share it?

  • Facebook
  • Twitter
  • Mail

About this article

Created 20 November 2020
Updated 30 March 2022

Changes to the intestinal microbiota have been linked to the severity of non-alcoholic steatohepatitis (NASH). However, the studies in question were limited to bacterial dysbioses, with patients’ viral microbiota having received little attention. Hence this prospective, cross-sectional and observational study on the links between the characteristics of the intestinal virome and the different histological stages of the disease. To this end, the researchers sequenced the metagenome of stool viruses in 73 NASH patients at various stages of the disease and of those in 22 control subjects. Patients with a high NAS score and advanced fibrosis are at increased risk of disease progression, carcinoma, and death.

Severity associated with viral diversity

Compared to the 29 NASH patients with a low histological score (NAS 0-4) or the control subjects, the 44 patients with a high NAS score (5-8) or cirrhosis showed:

- a significant loss of intestinal viral diversity

- a significant reduction in the proportion of (sidenote: Bacteriophage Virus that specifically targets and infects bacteria Scitable by Nature education_2014. Bacteriophage definition )  compared to other types of intestinal viruses, which was even more pronounced in patients using PPIs (proton-pump inhibitors).

In addition, the severity of fibrosis increased with viral dysbiosis.

Cause or consequence?

Therefore, two NASH severity markers (NAS score and fibrosis) were associated with significant decreases in viral diversity and bacteriophage abundance. However, these links were merely correlative, with further studies required to determine whether viral dysbiosis is a cause or consequence of NASH and to understand the mechanisms involved. The virome may directly affect the host by triggering an immune response and/or influence the bacterial microbiota, with an increase in certain Lactococcal phages (common in the most severe cases) and Bacteroides spp. associated with a decrease in these bacteria.

A predictive model?

The second step consisted of building a model that included a viral diversity index and simple clinical variables (age, platelet level, etc.), which was able to identify:

- patients with severe forms, with a reliability of 0.95

- F2-F4 stage fibroses, with a reliability of 0.88

The addition of viral diversity data significantly improved the models, compared to those based solely on clinical parameters or bacterial diversity–two criteria on which another team recently based their diagnosis of liver cirrhosis and distinguished it from fibrosis. Therefore, instead of carrying out highly invasive biopsies, it may be possible to identify patients at risk of NASH (as well as therapeutic targets) by analyzing fecal viromes.

 

Sources

Lang S, Demir M, Martin A et al. Intestinal Virome Signature Associated With Severity of Nonalcoholic Fatty Liver Disease. Gastroenterology. 2020 Jul 8:S0016-5085(20)34923-4.

Old sources

 

 

Tags
Virome Dysbiosis Non-alcoholic steatohepatitis NASH Fibrosis Diagnosis Liver Hepatic cirrhosis

en_view en_sources

    Created 20 November 2020
    Updated 30 March 2022

    About this article

    To know more about this topic.

    Main topic

    Hepatitis

    Medical practice

    Hepatology Gastroenterology

    Content type

    News
    Gastroenterology

    The blue poop challenge: a reliable method to evaluate gut transit?

    By Pr. Gianluca Ianiro Gastroenterology Department, Fondazione Policlinico Universitario Agostino Gemelli- ...

    Find out more

    New perspectives in autism: the role of microbiota in social communication

    Overview By Dr. Vincent Trebossen Child and Adolescent P...

    Find out more

    Gut microbiota #15

    By Pr. Markku Voutilainen Turku University Faculty of Medicine; Turku University Hospital, Department of Ga...

    Find out more

    Microbiome topics at gastro 2021

    Congress Review By Pr. Eamonn M M Quigley Lynda K and David M Underwood Center for Digestive Disorders, Di...

    Find out more

    Commensal clostridiales strains mediate effective anti-cancer immune response against solid tumours

    Commented articles - Adults' section By Pr. Harry Sokol ...

    Find out more

    Microbiota in covid-19 pandemic

    Overview By Pr. Conceição Calhau NOVA Medical School, New University of Lisbon, Portugal By Pr. Pedro Povo...

    Find out more

    Association between fungal dysbiosis and environment

    The fungal portion of the gut microbiota (or mycobiota) has been much less studied than the bacterial porti...

    Find out more

    From diarrhea to chronic diseases: the well-documented consequences of antibiotic-related gut microbiota dysbiosis

    Antibiotic treatment may sometimes take place without any...

    Find out more

    Continue reading

    News
    26.04.2022

    Severe obesity: the vicious circle of biotin metabolism

    Read the article
    22.04.2022

    SCFAs: new intestinal markers of Parkinson’s disease?

    Read the article
    15.04.2022

    Multiple sclerosis and microbiota: does meat consumption play a role?

    Read the article
    08.04.2022

    Inflammatory Bowel Disease (IBD): do microplastics condition severity?

    Read the article
    04.04.2022

    The microbiota, a significant factor in smoking cessation

    Read the article
    30.04.2019

    The lingual microbiota, biomarker of pancreatic cancer?

    Read the article
    15.06.2021

    Autism: link between severity of the disorder and changes in the gut microbiota?

    Read the article
    Actu PRO : A chaque tumeur son microbiote
    20.11.2020

    Each tumor has its own microbiota

    Read the article
    What's worth reading about microbiota
    Follow us on Twitter
    Read our thematic folder
    The Janus face of Antibiotics: Life Savers & Microbiota Disrupters
    NL13_cover
    Check out latest newsletter
    IBS, Microbiota & Covid-19
    • Our publications
      • News
      • Microbiota Mag
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographic
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • YouTube

    Lay public section

    Find here your dedicated section
    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology
    • English
    • Français
    • Español
    • Russian

    Browse the site

    • Our publications
      • News
      • Microbiota Mag
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographic
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • YouTube

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology

    Join the microbiota community

    • Facebook
    • Twitter
    • YouTube

    Lay public section

    Find here your dedicated section

    en_redirection

    en_you_are_about_to_leave

    • en_be_redirected
    • en_stay_on_biocodex

    Stay with us !

    Join the Microbiota Community of HCPs and researchers and receive once a month the “Microbiota Digest” to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    Explore

    04.05.2022

    Miscarriage: Is vaginal dysbiosis a suspect?

    Read the article
    26.04.2022

    Severe obesity: the vicious circle of biotin metabolism

    Read the article
    22.04.2022

    SCFAs: new intestinal markers of Parkinson’s disease?

    Read the article

    Stay updated

    Join the Microbiota Community of HCPs and researchers and receive once a month the “Microbiota Digest” to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    • Our publications
      • News
      • Microbiota Mag
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographic
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • YouTube

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology

    Lay public section

    Find here your dedicated section

    Join the microbiota community

    • Facebook
    • Twitter
    • YouTube

    © 2022 Biocodex. All rights reserved.

    • Cookies Policy
    • Data protection policy
    • GTU
    • Sitemap
    • Cookies settings
    Biocodex logo