Skip to main content
About the Institute
  • English
  • Français
  • Español
  • Portuguese
  • Polish

Breadcrumb

  1. Home
  2. Pediatrics
  3. When an infant’s sleep hinges on a few bacteria
  • Our publications
    • News
    • Microbiota Mag
    • Thematic pages
    • Experts' point of view
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • About us
    • International Microbiota Observatory
    • Press room
    • Partnerships
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
  • Useful documents
    • How to talk about
    • Infographics
    • IBS Diagnosis Check List
    • Patients Stories

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube
    • Instagram
    • Bluesky

Lay public section

Find here your dedicated section
Gastroenterology
Gynecology
Pediatrics
General Medicine

Breadcrumb

  1. Home
  2. Pediatrics
  3. When an infant’s sleep hinges on a few bacteria
Pediatrics

When an infant’s sleep hinges on a few bacteria

Sleep
Pediatrics Gastroenterology General Medicine

Pediatricians will now be able to provide a response to new parents exhausted by their newborn’s late-night antics: children’s sleep is now thought to be connected with gut microbiota too... and both may have an influence on their behavior later in life.

Gastroenterology
Gynecology
Pediatrics
General Medicine
  • Our publications
    • News
    • Microbiota Mag
    • Thematic pages
    • Experts' point of view
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • About us
    • International Microbiota Observatory
    • Press room
    • Partnerships
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
  • Useful documents
    • How to talk about
    • Infographics
    • IBS Diagnosis Check List
    • Patients Stories

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube
    • Instagram
    • Bluesky

Lay public section

Find here your dedicated section

Sources

This article is based on scientific information

Sharing is caring

Your colleagues might be interested in this topic. Why not share it?

  • Facebook
  • Twitter
  • LinkedIn
  • Mail

About this article

Created 11 March 2022
Updated 10 February 2025

A sleep-brain-gut linkage. That is what a recent study has found. We already knew that in adults, sleep and gut microbiota were doubly interrelated: a deterioration in sleep modifies the composition of the gut microbiota and, conversely, the microbial composition of the gut impacts sleep. But we did not previously know the age at which this two-way link became established between sleep and gut microbiota, or what the potential consequences on development might be.

This was what justified this longitudinal study involving 162 healthy infants at 3, 6, 12 and 24 months of age.

There is a connection between sleep and gut microbiota as early as 3 months of age

First confirmation: the composition of the gut microbiota does indeed start to change as of 6 months of age. The majority of the children in the study experienced a change in flora which went from predominantly Bifidobacterium (enterotype A) to a microbiota rich in Bacteroides (enterotype B), with increased (sidenote: α diversity A measurement indicating the diversity of a single sample, i.e. the number of different species present in an individual. Hamady M, Lozupone C, Knight R. Fast UniFrac: facilitating high-throughput phylogenetic analyses of microbial communities including analysis of pyrosequencing and PhyloChip data. ISME J. 2010 Jan;4(1):17-27. ) .

Authors’ reservation: this study found only 2 enterotypes (as opposed to 3 in other studies), possibly due to the homogeneity of the cohort (Swiss children born at full term via vaginal delivery, breastfed, no antibiotics, etc.).

Above all, the study demonstrates a link between sleep habits and gut microbiota from as early as 3 months: 

  • Daytime sleep (duration, number of naps and their regularity) has a negative association with bacterial diversity: infants who sleep the most during the day have less bacterial diversity;
  • Nighttime sleep fragmentation and variability are linked to bacterial maturity and enterotype: infants with more mature gut microbiota have higher levels of activity at night (waking up more often during the night). Additionally, their enterotype does not change from enterotype A to B between the ages of 6 and 12 months.

Sleep, brain and gut: all linked?

The brain activity analyzed using the nighttime electroencephalograms at the age of 6 months proved to be rich with useful findings. 

First finding: infants with predominantly Bifidobacterium flora showed less slow-wave sleep (“light sleep”);
Second finding: the quality of sleep at 6 months of age can be used to predict the bacterial diversity of the gut microbiota at age 1. The presence of more theta waves at 6 months is a sign that there will be lower bacterial diversity at 12 months.

Lastly, the gut microbiota at 6 months and above all sleep at 6 and 12 months of age predict the behavioral development of the child at 24 months.

These results demonstrate the existence of a dynamic interaction between sleep, the gut microbiota, brain maturation and behavior during early childhood. This is the concept of the sleep-brain-gut linkage. Clinical impact: numerous illnesses become established during early childhood, so monitoring children’s sleep and gut microbiota (pre- and probiotics, effects of antibiotic therapies) during that stage of life would therefore appear to be essential.

Sources

Schoch SF, Castro-Mejía JL, Krych L et al. From Alpha Diversity to Zzz: Interactions among sleep, the brain, and gut microbiota in the first year of life. Prog Neurobiol. 2021 Dec 16;209:102208.

Tags
Sleep Gut-brain axis Dysbiosis Microbiome Flora

    See also

    The infant's gut at the heart of immunity
    Pr. Olivier Goulet : Gastrointestinal disorders in children, the need to act
    Created 11 March 2022
    Updated 10 February 2025

    About this article

    To know more about this topic.

    Main topic

    Sleep

    Medical practice

    Pediatrics Gastroenterology General Medicine

    Content type

    News

    Continue reading

    News
    28.02.2025

    The gut microbiota and sleep disorder: a therapeutic approach based on modulation of the microbiota?

    Read the article
    13.01.2023

    Insomnia in seniors: a link with the gut microbiota

    Read the article
    26.02.2024

    Gut bacteria implicated in sleep apnea

    Read the article
    25.04.2023

    F. prausnitzii : a biomarker of chronic fatigue syndrome

    Read the article
    • Our publications
      • News
      • Microbiota Mag
      • Thematic pages
      • Experts' point of view
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • About us
      • International Microbiota Observatory
      • Press room
      • Partnerships
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
    • Useful documents
      • How to talk about
      • Infographics
      • IBS Diagnosis Check List
      • Patients Stories

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube
      • Instagram
      • Bluesky

    Lay public section

    Find here your dedicated section
    Gastroenterology
    Gynecology
    Pediatrics
    General Medicine
    • English
    • Français
    • Español
    • Portuguese
    • Polish

    Browse the site

    • Our publications
      • News
      • Microbiota Mag
      • Thematic pages
      • Experts' point of view
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • About us
      • International Microbiota Observatory
      • Press room
      • Partnerships
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
    • Useful documents
      • How to talk about
      • Infographics
      • IBS Diagnosis Check List
      • Patients Stories

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube
      • Instagram
      • Bluesky

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    General Medicine

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube
    • Instagram
    • Bluesky

    Lay public section

    Find here your dedicated section

    Redirection

    You are about to be redirected and leave our website

    • Be redirected
    • Stay on the Biocodex Microbiota Institute's website

    Stay with us !

    Join the Microbiota Community of HCPs and researchers and receive “Microbiota Digest” and "Microbiota Mag" to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    Explore

    14.05.2025

    Towards worldwide redefinition of healthy vaginal microbiota

    Read the article
    07.05.2025

    The microbial-metabolic nexus in colon cancer

    Read the article
    02.05.2025

    A new lens on chlamydia: beyond behavior, into the microbiome

    Read the article

    Stay updated

    Join the Microbiota Community of HCPs and researchers and receive “Microbiota Digest” and "Microbiota Mag" to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    • Our publications
      • News
      • Microbiota Mag
      • Thematic pages
      • Experts' point of view
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • About us
      • International Microbiota Observatory
      • Press room
      • Partnerships
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
    • Useful documents
      • How to talk about
      • Infographics
      • IBS Diagnosis Check List
      • Patients Stories

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube
      • Instagram
      • Bluesky

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    General Medicine

    Lay public section

    Find here your dedicated section

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube
    • Instagram
    • Bluesky

    © 2025 Biocodex. All rights reserved.

    • Legal notice
    • GTU
    • Data protection policy
    • Sitemap
    • Cookies settings
    • Digital accessibility : partially compliant
    Biocodex logo