Skip to main content
About the Institute
  • English
  • Français
  • Español
  • Russian
  • Portuguese

Breadcrumb

  1. Home
  2. Gastroenterology
  3. Lantibiotics: a new avenue in the fight against resistant bacteria
  • Our publications
    • News
    • Microbiota Mag
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • Partnerships
    • Press room
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
    • Xpeer App
  • Useful documents
    • Infographics
    About the Institute

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

Lay public section

Find here your dedicated section
Gastroenterology
Gynecology
Pediatrics
Dermatology

Breadcrumb

  1. Home
  2. Gastroenterology
  3. Lantibiotics: a new avenue in the fight against resistant bacteria
Gastroenterology

Lantibiotics: a new avenue in the fight against resistant bacteria

Drug
Gastroenterology

Colonization of the gastrointestinal tract by a strain of vancomycin-resistant Enterococcus faecium could largely be reduced by the administration of bacteria that naturally synthesize an effective and selective lantibiotic.

Gastroenterology
Gynecology
Pediatrics
Dermatology
  • Our publications
    • News
    • Microbiota Mag
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • Partnerships
    • Press room
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
    • Xpeer App
  • Useful documents
    • Infographics
    About the Institute

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

Lay public section

Find here your dedicated section

Sources

This article is based on scientific information

Sharing is caring

Your colleagues might be interested in this topic. Why not share it?

  • Facebook
  • Twitter
  • LinkedIn
  • Mail
Photo : Lantibiotics: a new avenue in the fight against resistant bacteria

About this article

Created 26 November 2019
Updated 29 March 2022

 

How can we fight against the transmission of pathogens highly resistant to antibiotics such as vancomycin-resistant Enterococcus faecium (VRE)in healthcare facilities? A promising approach is based on the reinforcement of the gut resistance to colonization through the administration of protective gut bacteria. In mice, bacterial transplant seems to restore the resistance to colonization and reduce the gut density of VRE. This was achieved via the combination called “CBBPSCSK” of 4 bacterial strains, including Blautia producta (BPSCSK; where SCSK designates the Blautia strain). However, the underlying mechanisms at play still had to be elucidated. This was partially accomplished by the works recently published in Nature by American researchers.

A lantibiotic similar to E234 preservative

Based on experimental results, BPSCSK could help reduce the growth of VRE by secreting a (sidenote: Lantibiotic  Low molecular weight bacterial peptide with antimicrobial activity produced by a large number of Gram-positive bacteria ) , similar to nisin A, which is produced by Lactococcus lactis and largely used in the food industry as preservative (E234). Similar...but way more effective and selective.

More effective and selective in vivo

Although VRE growth is inhibited both by BPSCSK and L. lactis in vitro, things are very different in vivo: only BPSCSK is detected in the colon (where it represents about 25% of bacteria present 5 days after the administration of CBBPSCSK); it reduces the density of VRE and inhibits Gram+ pathogens while preserving other gut commensal bacteria. On the contrary, L. lactis is not able to colonize the gastrointestinal tract and has a wider spectrum of action, at the expense of some beneficial bacteria.

A potential probiotic agent

The results also emphasize that genes encoding for the synthesis of lantibiotics are naturally present in human microbiomes from healthy individuals; and that lantibiotic-producing species inhibit VRE. Moreover, in 22 patients with a high risk of contracting VRE infection (because they were undergoing a hematopoietic cell transplant), a high abundance of lantibiotic-coding genes was associated to a reduced density of E. faecium. Similarly, in germ-free mice transplanted with fecal preparations from these patients, the resistance to colonization by VRE is correlated to the abundance of the lantibiotic gene. This supports the idea that lantibiotic-producing gut bacteria reduce the colonization by VRE and are potential probiotic agents that could restore resistance towards this pathogen.

 

Sources

Kim SG, Becattini S, Moody TU, et al. Microbiota-derived lantibiotic restores resistance against vancomycin-resistant Enterococcus. Nature. 2019 Aug;572(7771):665-669.

Tags
Lantibiotics Antibiotic VRE

en_view en_sources

    Created 26 November 2019
    Updated 29 March 2022

    About this article

    To know more about this topic.

    Main topic

    Drug

    Medical practice

    Gastroenterology

    Content type

    News
    Gastroenterology

    Your IBS Diagnosis Check List

    How many patients suffering from gut disorder do you see per week? How many are diagnosed with Irritable Bo...

    Find out more

    Human milk nutrient fortifiers alter the developing gastrointestinal microbiota of very-low-birth-weight infants

    Commented article - Children's section By Pr. Emmanuel M...

    Find out more

    Impact of beer and non alcoholic consumption on the gut microbiota

    By Pr. Bernd SchnablDivision of Gastroenterology, San Diego Digestive Diseases Research Center (SDDRC), UC ...

    Find out more

    Everything you need to know about Irritable Bowel Syndrome (IBS)

    Accrediting training, infographics, expert’s video, thematic folder, news… Biocodex Microbiota Institute pr...

    Find out more

    Gut Microbiota #17

    By Pr. Satu PekkalaAcademy of Finland Research Fellow, Faculty of Sport and Health Sciences, University of ...

    Find out more

    Gut Microbiota # 16

    By Pr. Satu PekkalaAcademy of Finland Research Fellow, Faculty of Sport and Health Sciences, University of ...

    Find out more

    Highlights from the UEGW

    By Dr. Lucas WautersGastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium

    Find out more

    The Gut-Brain axis

    By Pr. Sarkis K. Mazmanian, John W. Bostick, Nadia SuryawinataBiology and Biological Engineering, Californi...

    Find out more

    Continue reading

    News
    20.03.2023

    The role of Bifidobacteria in irritable bowel syndrome (IBS)

    Read the article
    14.03.2023

    Positive impact of running on gut microbiota and adolescent depression

    Read the article
    09.03.2023

    Each subtype of Irritable Bowel Syndrome (IBS) has its own dysbiosis

    Read the article
    Parkinson : le microbiote intestinal, chef d’orchestre des mécanismes pathogéniques ?
    27.02.2023

    Does the gut microbiota orchestrate pathogenic mechanisms in Parkinson’s disease?

    Read the article
    Everything you need to know about Microbiota & Immunity
    15.09.2022

    Everything you need to know about Microbiota & Immunity

    Read the article
    The psychobiotic diet: modulating gut microbiota to reduce stress
    13.02.2023

    The psychobiotic diet: modulating gut microbiota to reduce stress

    Read the article
    30.01.2023

    Schizophrenia and aggressive behavior: what involvement of the intestinal microbiota?

    Read the article
    23.01.2023

    Idiopathic urethritis in men: new infectious etiologies?

    Read the article
    What's worth reading about microbiota
    Follow us on Twitter
    Read our thematic folder
    The Janus face of Antibiotics: Life Savers & Microbiota Disrupters
    NL13_cover
    Check out latest newsletter
    IBS, Microbiota & Covid-19
    • Our publications
      • News
      • Microbiota Mag
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographics
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube

    Lay public section

    Find here your dedicated section
    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology
    • English
    • Français
    • Español
    • Russian
    • Portuguese

    Browse the site

    • Our publications
      • News
      • Microbiota Mag
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographics
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

    Lay public section

    Find here your dedicated section

    Redirection

    You are about to be redirected and leave our website

    • Be redirected
    • Stay on the Biocodex Microbiota Institute's website

    Stay with us !

    Join the Microbiota Community of HCPs and researchers and receive “Microbiota Digest” and "Microbiota Mag" to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    Explore

    20.03.2023

    The role of Bifidobacteria in irritable bowel syndrome (IBS)

    Read the article
    14.03.2023

    Positive impact of running on gut microbiota and adolescent depression

    Read the article
    09.03.2023

    Each subtype of Irritable Bowel Syndrome (IBS) has its own dysbiosis

    Read the article

    Stay updated

    Join the Microbiota Community of HCPs and researchers and receive “Microbiota Digest” and "Microbiota Mag" to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    • Our publications
      • News
      • Microbiota Mag
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographics
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology

    Lay public section

    Find here your dedicated section

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

    © 2022 Biocodex. All rights reserved.

    • Cookies Policy
    • Data protection policy
    • GTU
    • Sitemap
    • Cookies settings
    Biocodex logo