Skip to main content
About the Institute
  • English
  • Français
  • Español
  • Russian
  • Portuguese
  • Polish

Breadcrumb

  1. Home
  2. Gastroenterology
  3. A new, unanticipated marker for predicting the clinical course of prostate cancer: gut microbiota
  • Our publications
    • News
    • Microbiota Mag
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • Partnerships
    • Press room
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
    • Xpeer App
  • Useful documents
    • Infographics
    • IBS Diagnosis Check List
    About the Institute

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

Lay public section

Find here your dedicated section
Gastroenterology
Gynecology
Pediatrics
Dermatology

Breadcrumb

  1. Home
  2. Gastroenterology
  3. A new, unanticipated marker for predicting the clinical course of prostate cancer: gut microbiota
Gastroenterology

A new, unanticipated marker for predicting the clinical course of prostate cancer: gut microbiota

Cancer
Gastroenterology

According to a new study published in Cancer Science, the composition of the intestinal microbiota could be used as a marker of increased risk of prostate cancer.

Gastroenterology
Gynecology
Pediatrics
Dermatology
  • Our publications
    • News
    • Microbiota Mag
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • Partnerships
    • Press room
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
    • Xpeer App
  • Useful documents
    • Infographics
    • IBS Diagnosis Check List
    About the Institute

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

Lay public section

Find here your dedicated section

Sources

This article is based on scientific information

Sharing is caring

Your colleagues might be interested in this topic. Why not share it?

  • Facebook
  • Twitter
  • LinkedIn
  • Mail

About this article

Created 08 November 2021
Updated 20 January 2022

Having demonstrated that intestinal bacteria and their metabolites (short chain fatty acids, SCFA) promote the growth of cancer cells in mouse models of prostate cancer, the researchers in this new study wished to further explore the link between intestinal microbiota (IM) and the prognosis for prostate cancer in men. Their findings are surprising, to say the least.

A “discovery” cohort and a “test” cohort 

The study included 152 Japanese men who had undergone a prostate biopsy (96 positive and 56 negative). The men were randomised to two cohorts: “discovery” (114 patients) and “test” (38 patients). Two comparison groups were defined in each cohort: a high grade group (men with grade 2 prostate cancer or above) and a negative/grade 1 group (men with a negative biopsy or grade 1 prostate cancer). Samples were taken during rectal examination prior to administration of prophylactic antibiotics and prostate biopsy. ARNr 16S gene sequencing was used to determine the composition of the gut microbiota.
 

A greater abundance of specific bacteria indicates a high grade

While there no significant difference was observed in bacterial diversity between the patient groups, three bacterial taxa, Rikenellaceae, Alistipes and Lachnospira, were present in greater numbers in patients with a high grade prostate cancer. There was no link between the presence of such bacteria and patients’ metastatic status. Microbial data were also used to predict the functional profiles of patients’ microbiota: (sidenote: Starch and sucrose metabolism, phenylpropanoid biosynthesis, phenylalanine, tyrosine and tryptophan biosynthesis, cyanoamino acid metabolism and histidine metabolism )  were more prevalent in patients with high grade prostate cancer.

A faecal indicator for the prostate 

The researchers then investigated whether microbial profiles could be used to identify high-risk PCa patients in the test cohort. It was not possible to use the three bacteria identified above on their own to discern the men with a high grade prostate cancer. The LASSO regression model was employed to identify a further 18 operational taxonomic units. These bacterial groups were highly correlated (positively or negatively) with high-risk PCa in the discovery cohort and were used to create a Fecal Microbiome Prostate Index (FMPI). In the test cohort, not only was the FMPI significantly higher in patients with high-grade PCa (P < 0.001), but it also detected these patients with greater accuracy than conventional serum prostate-specific antigen (PSA) assay. 

While these results are highly encouraging, the study cohort only included Japanese men living in an urban area and with similar lifestyles. The scope of the research will need to be widened to additional populations to corroborate these initial findings.

Sources

Matsushita M, Fujita K, Motooka D, et al. The gut microbiota associated with high-Gleason prostate cancer [published online ahead of print, 2021 May 29]. Cancer Sci. 2021;10.1111/cas.14998. doi:10.1111/cas.14998

Tags
Cancer Prostate Biopsy Gastroenterology

en_view en_sources

    See also

    Actu PRO : Le microbiote intestinal, un nouvel acteur dans les thérapies contre le cancer de la prostate ? Gut microbiota: a new player in prostate cancer therapies?
    Created 08 November 2021
    Updated 20 January 2022

    About this article

    To know more about this topic.

    Main topic

    Cancer

    Medical practice

    Gastroenterology

    Content type

    News
    Gastroenterology

    Everything you need to know about Irritable Bowel Syndrome (IBS)

    Accrediting training, infographics, expert’s video,...

    Find out more

    Your IBS Diagnosis Check List

    How many patients suffering from gut disorder do you see per week? How many are diagnosed with Irrita...

    Find out more

    Human milk nutrient fortifiers alter the developing gastrointestinal microbiota of very-low-birth-weight infants

    Commented article - Children's section By Pr. Emma...

    Find out more

    Impact of beer and non alcoholic consumption on the gut microbiota

    By Pr. Bernd SchnablDivision of Gastroenterology, S...

    Find out more

    Gut Microbiota #17

    By Pr. Satu PekkalaAcademy of Finland Research Fellow, Faculty of Sport and Health Sciences, Universi...

    Find out more

    Gut Microbiota # 16

    By Pr. Satu PekkalaAcademy of Finland Research Fellow, Faculty of Sport and Health Sciences, Universi...

    Find out more

    Highlights from the UEGW

    By Dr. Lucas WautersGastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium ...

    Find out more

    The Gut-Brain axis

    By Pr. Sarkis K. Mazmanian, John W. Bostick, Nadia SuryawinataBiology and Biological Engineering, Cal...

    Find out more

    Continue reading

    News
    Everything you need to know about the microbiota gut-brain axis
    22.05.2023

    Everything you need to know about the microbiota gut-brain axis

    Read the article
    SII, microbiote intestinal et dépression : un triptyque pour mieux comprendre la maladie
    27.07.2022

    IBS, gut microbiota and depression: a trio shedding light on the disease

    Read the article
    Actu PRO : Cancer du poumon : le microbiote intestinal signerait un stade précoce
    02.07.2020

    Gut microbiota could be an indicator of early-stage lung cancer

    Read the article
    Obesity: Is a bacterial fatty acid involved?
    15.05.2023

    Obesity: Is a bacterial fatty acid involved?

    Read the article
    Photo: Endométriose : une clé de sa progression au sein du microbiote intestinal
    09.05.2023

    Endometriosis: A key to its progression in the gut microbiota?

    Read the article
    16.11.2022

    Alcohol use disorders: in microbiota veritas?

    Read the article
    Photo: Atténuer la dénutrition avec des biotiques ?
    26.04.2023

    Mitigating malnutrition with biotics?

    Read the article
    25.04.2023

    F. prausnitzii : a biomarker of chronic fatigue syndrome

    Read the article
    What's worth reading about microbiota
    Follow us on Twitter
    Read our thematic folder
    The Janus face of Antibiotics: Life Savers & Microbiota Disrupters
    Microbiota 17 EN
    Check out our latest magazine
    The first 1000 days of life
    • Our publications
      • News
      • Microbiota Mag
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographics
      • IBS Diagnosis Check List
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube

    Lay public section

    Find here your dedicated section
    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology
    • English
    • Français
    • Español
    • Russian
    • Portuguese
    • Polish

    Browse the site

    • Our publications
      • News
      • Microbiota Mag
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographics
      • IBS Diagnosis Check List
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

    Lay public section

    Find here your dedicated section

    Redirection

    You are about to be redirected and leave our website

    • Be redirected
    • Stay on the Biocodex Microbiota Institute's website

    Stay with us !

    Join the Microbiota Community of HCPs and researchers and receive “Microbiota Digest” and "Microbiota Mag" to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    Explore

    Everything you need to know about the microbiota gut-brain axis
    22.05.2023

    Everything you need to know about the microbiota gut-brain axis

    Read the article
    Obesity: Is a bacterial fatty acid involved?
    15.05.2023

    Obesity: Is a bacterial fatty acid involved?

    Read the article
    Photo: Endométriose : une clé de sa progression au sein du microbiote intestinal
    09.05.2023

    Endometriosis: A key to its progression in the gut microbiota?

    Read the article

    Stay updated

    Join the Microbiota Community of HCPs and researchers and receive “Microbiota Digest” and "Microbiota Mag" to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    • Our publications
      • News
      • Microbiota Mag
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographics
      • IBS Diagnosis Check List
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology

    Lay public section

    Find here your dedicated section

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

    © 2022 Biocodex. All rights reserved.

    • Cookies Policy
    • Data protection policy
    • GTU
    • Sitemap
    • Cookies settings
    Biocodex logo