Skip to main content
About the Institute
  • English
  • Français
  • Español
  • Russian
  • Portuguese

Breadcrumb

  1. Home
  2. Gastroenterology
  3. Ulcerative colitis: an innovative fecal transplant protocol
  • Our publications
    • News
    • Microbiota Mag
    • Thematic pages
    • Experts' point of view
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • Partnerships
    • Press room
    • International Microbiota Observatory
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
    • Xpeer App
  • Useful documents
    • Infographics
    • IBS Diagnosis Check List
    • Patients Stories
    About the Institute

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

Lay public section

Find here your dedicated section
Gastroenterology
Gynecology
Pediatrics
Dermatology

Breadcrumb

  1. Home
  2. Gastroenterology
  3. Ulcerative colitis: an innovative fecal transplant protocol
Gastroenterology

Ulcerative colitis: an innovative fecal transplant protocol

Ulcerative colitis
Gastroenterology

Preservation of anaerobic microorganisms in fecal transplants could lead to a less intensive but just as efficient treatment as standard methods in patients with ulcerative colitis.

Gastroenterology
Gynecology
Pediatrics
Dermatology
  • Our publications
    • News
    • Microbiota Mag
    • Thematic pages
    • Experts' point of view
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • Partnerships
    • Press room
    • International Microbiota Observatory
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
    • Xpeer App
  • Useful documents
    • Infographics
    • IBS Diagnosis Check List
    • Patients Stories
    About the Institute

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

Lay public section

Find here your dedicated section

Sources

This article is based on scientific information

Sharing is caring

Your colleagues might be interested in this topic. Why not share it?

  • Facebook
  • Twitter
  • LinkedIn
  • Mail
Photo : Ulcerative colitis: an innovative fecal transplant protocol

About this article

Created 05 March 2019
Updated 06 October 2021

 

While the involvement of the gut microbiota in chronic inflammatory bowel diseases (Crohn’s and ulcerative colitis) has been proven, the fecal microbiota transplant (FMT) is still being investigated. There seems to be a significant donor effect: the more diversified the transplanted microbiota, the better are the results. In this context, Australian researchers developed an innovative technique.

Preserved anaerobic microorganisms, streamlined protocol

Scientists hypothesized that anaerobic microorganisms could be involved in the therapeutic effect of fecal transplants for the treatment of UC. They thus developed a preparation technique that preserves these species which are largely destroyed by standard methods performed in the presence of oxygen. Their administration protocol was less intensive than those previously used: one dose (from a mix of several donors) received by colonoscopy followed by two doses administered through enemas in a 7‑day period, compared to one colonoscopy and five enemas per week during 8 weeks in the (sidenote: Paramsothy et al., Multidonor intensive faecal microbiota transplantation for active ulcerative colitis: a randomised placebo-controlled trial. Lancet 2017 ) .

Effective protocol on corticosteroid dependency

Seventy-three patients with mild to moderate UC were included in this trial. In addition to their background treatment, participants received prednisolone (doses < 25mg/day). Primary endpoint was complete corticosteroid weaning on Week 8, when a new colonoscopy was performed as well as a clinical examination. In the group receiving FMT from donors (dFMT), remission rate was 32%, compared to 9% in the control group who received autologous FMT (aFMT). Average decrease in overall (sidenote: MAYO score https://www.igibdscores.it/en/info-mayo-full.html ) was 3.5 points in the dFMT group (4 patients attained a Mayo score of 0), vs. 1.2 points in the aFMT group. It should also be noted that the greater abundance of both anaerobic species (Anaerofilum pentosovorans and Bacteroides coprophilus) was strongly associated to an improvement of the disease in the dFMT group. This study confirms the benefits of FMT in the treatment of UC and concludes that an anaerobic preparation method could streamline therapeutic protocol and improve patients’ lives, while maintaining the same efficacy.

 

Sources

Costello et al., Effect of Fecal Microbiota Transplantation on 8-Week Remission in Patients With Ulcerative Colitis A Randomized Clinical Trial, JAMA 2019 Jan 15;321(2):156-164.

Paramsothy et al., Multidonor intensive faecal microbiota transplantation for active ulcerative colitis : a randomised placebo-controlled trial, Lancet 2017 Mar 25;389(10075):1218-1228.

Transplantation fécale, Harry Sokol, Association française de FMC en Hépato-gastro-entérologie

Tags
Transplantation Fecal transplant FMT CIBD Anaerobia UC

en_view en_sources

    Created 05 March 2019
    Updated 06 October 2021

    About this article

    To know more about this topic.

    Main topic

    Ulcerative colitis

    Medical practice

    Gastroenterology

    Content type

    News
    Gastroenterology

    Gut Microbiota #18

    By Pr. Satu PekkalaAcademy of Finland Research Fellow, Faculty of Sport and Health Sciences, University of ...

    Find out more

    Rural environment reduces allergic inflammation by modulating the gut microbiota

    COMMENTED ARTICLE - Children’s section By Pr.Emmanuel Ma...

    Find out more

    A pan-cancer mycobiome analysis reveals fungal involvement in gastrointestinal and lung tumours

    COMMENTED ARTICLE - ADULTS’ SECTION By Pr. Harry SokolGa...

    Find out more

    Covid-19 & the gut microbiota

    OverviewBy Pr. Tao ZuoSYSU Research Institute of Gastroenterology, Guangdong Institute of Gastroenterology,...

    Find out more

    Artificial sweeteners, gut microbiota and metabolic health: an interaction requiring close examination

    By Pr. Karine ClémentSorbonne University, Inserm, Unité d...

    Find out more

    Highlights of Gut Microbiota for Health - World Summit 2023

    By Dr. Nicolas BenechGastroenterology and hepatology, Microbiota Study Group, Hospices Civils de Lyon, Lyon...

    Find out more

    Everything you need to know about Irritable Bowel Syndrome (IBS)

    Accrediting training, infographics, expert’s video, thematic folder, news… Biocodex Microbiota Institute pr...

    Find out more

    Your IBS Diagnosis Check List

    How many patients suffering from gut disorder do you see per week? How many are diagnosed with Irritable Bo...

    Find out more

    Continue reading

    News
    25.10.2022

    Antibiotics: Dr Jekyll and Mr Hyde

    Read the article
    13.09.2023

    Parkinson’s disease: Desulfovibrio bacteria have been found guilty

    Read the article
    18.11.2020

    Gut microbiota signature for cirrhosis

    Read the article
    29.08.2023

    Massive amounts of antibiotic resistance genes found in clouds

    Read the article
    29.08.2023

    Ulcerative colitis: a randomized controlled trial highlights the positive effects of the Mediterranean diet

    Read the article
    Immune checkpoint inhibitor (ICI) efficacy: the right dose of bacteria
    02.06.2022

    Immune checkpoint inhibitor (ICI) efficacy: the right dose of bacteria

    Read the article
    21.03.2022

    Endometriosis and Microbiota: what are the links ?

    Read the article
    Antibiotiques : le mycobiote des nourrissons sous influence
    16.08.2022

    The effect of antibiotics on infant mycobiota

    Read the article
    What's worth reading about microbiota
    Follow us on Twitter
    Read our thematic folder
    The Janus face of Antibiotics: Life Savers & Microbiota Disrupters
    Microbiota 17 EN
    Check out our latest magazine
    The first 1000 days of life
    • Our publications
      • News
      • Microbiota Mag
      • Thematic pages
      • Experts' point of view
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
      • International Microbiota Observatory
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographics
      • IBS Diagnosis Check List
      • Patients Stories
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube

    Lay public section

    Find here your dedicated section
    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology
    • English
    • Français
    • Español
    • Russian
    • Portuguese

    Browse the site

    • Our publications
      • News
      • Microbiota Mag
      • Thematic pages
      • Experts' point of view
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
      • International Microbiota Observatory
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographics
      • IBS Diagnosis Check List
      • Patients Stories
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

    Lay public section

    Find here your dedicated section

    Redirection

    You are about to be redirected and leave our website

    • Be redirected
    • Stay on the Biocodex Microbiota Institute's website

    Stay with us !

    Join the Microbiota Community of HCPs and researchers and receive “Microbiota Digest” and "Microbiota Mag" to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    Explore

    13.09.2023

    Parkinson’s disease: Desulfovibrio bacteria have been found guilty

    Read the article
    29.08.2023

    Massive amounts of antibiotic resistance genes found in clouds

    Read the article
    29.08.2023

    Ulcerative colitis: a randomized controlled trial highlights the positive effects of the Mediterranean diet

    Read the article

    Stay updated

    Join the Microbiota Community of HCPs and researchers and receive “Microbiota Digest” and "Microbiota Mag" to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    • Our publications
      • News
      • Microbiota Mag
      • Thematic pages
      • Experts' point of view
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
      • International Microbiota Observatory
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographics
      • IBS Diagnosis Check List
      • Patients Stories
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology

    Lay public section

    Find here your dedicated section

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

    © 2022 Biocodex. All rights reserved.

    • Cookies Policy
    • Data protection policy
    • GTU
    • Sitemap
    • Cookies settings
    Biocodex logo