Skip to main content
About the Institute
  • English
  • Français
  • Español
  • Russian
  • Portuguese
  • Polish

Breadcrumb

  1. Home
  2. Diet and health: the role of the intestinal microbiota in metabolic diseases
  3. Probiotics at the service of “fatty liver” syndrome
  • Learn all about microbiota
    • The gut microbiota
    • The ENT microbiota
    • The pulmonary microbiota
    • The urinary microbiota
    • The skin microbiota
    • The vaginal microbiota
  • Microbiota and related conditions
    • Digestive disorders
    • Women disorders
    • Metabolic disorders
    • Skin disorders
    • Pediatric disorders
    • Psychiatric disorders
    • Neurological disorders
    • Respiratory disorders
    • Urinary disorders
  • Act on your microbiota
    • Probiotics
    • Prebiotics
    • Fecal Microbiota Transplant
    • Diet
  • Publications
    • News
    • Thematics folders
    • Thematic pages
    • Microbiota Q & A
    • Patients Stories
    • Experts' point of view
  • About the Institute
    • About us
    • International Microbiota Observatory
    • Press room
    • Partnerships

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

Healthcare professionals section

Find here your dedicated section
Biocodex logo
The power of your gut
My microbiota as a woman
Our marvelous microbiota

Breadcrumb

  1. Home
  2. Diet and health: the role of the intestinal microbiota in metabolic diseases
  3. Probiotics at the service of “fatty liver” syndrome
The power of your gut

Probiotics at the service of “fatty liver” syndrome

Diet
The gut microbiota Diet Probiotics

To lighten the global burden of metabolic diseases, we would need to be able to make a large part of the planet adopt healthier dietary habits. A necessary but difficult task. Simultaneously, interventions at the heart of intestinal bacterial dynamics are under consideration: will probiotics and fecal microbiota transplants be the great new metabolic therapies of tomorrow?

The power of your gut
My microbiota as a woman
Our marvelous microbiota
  • Learn all about microbiota
    • The gut microbiota
    • The ENT microbiota
    • The pulmonary microbiota
    • The urinary microbiota
    • The skin microbiota
    • The vaginal microbiota
  • Microbiota and related conditions
    • Digestive disorders
    • Women disorders
    • Metabolic disorders
    • Skin disorders
    • Pediatric disorders
    • Psychiatric disorders
    • Neurological disorders
    • Respiratory disorders
    • Urinary disorders
  • Act on your microbiota
    • Probiotics
    • Prebiotics
    • Fecal Microbiota Transplant
    • Diet
  • Publications
    • News
    • Thematics folders
    • Thematic pages
    • Microbiota Q & A
    • Patients Stories
    • Experts' point of view
  • About the Institute
    • About us
    • International Microbiota Observatory
    • Press room
    • Partnerships

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

Healthcare professionals section

Find here your dedicated section
Biocodex logo

Sources

This article is based on scientific information

Sharing is caring

Your friends might be interested in this topic. Why not share it?

  • Facebook
  • Twitter
  • Mail

Sections

Bandeau_Article4_DTO

About this article

Created 26 September 2019
Updated 30 December 2021

Far from being a French specialty, “fatty liver” syndrome (foie gras in French) is driving up the number of hepatitis cases all around the world. Research is turning with increasing seriousness towards probiotics to stem these new epidemics9. And the gamble seems to have paid off.

Cases of viral, alcoholic, and now increasingly fatty, hepatitis are soaring due to obesity and type 2 diabetes. Excess fat accumulates in liver tissue, first causing non-alcoholic hepatic steatosis (NAFLD10) which can escalate into non-alcoholic steatohepatitis (the famous NASH11), itself heralding cirrhosis–point of no return for the liver. As in obesity and type 2 diabetes, the intestinal microbiota plays a frontline role. Hence the hope of countering this overdose of fat through probiotics: an avenue followed with success by research for around ten years.

From animals to humans

The first studies in animal models proved the benefits of using probiotics and prebiotics, and even synbiotics (a combination of the two). By way of example, the addition of fructooligosaccharides to probiotics led to a reduction in inflammation and in fatty particles in the liver, loss of weight and fat mass, and improved insulin sensitivity in some patients. These positive results were confirmed by the decrease in fat content of the liver in Hong Kong patients treated for six months with a mixture of lactobacilli and bifidobacteria. Decreased liver stiffness–a sign of diminished aggression–was observed in Iranian patients after taking synbiotics for twenty-eight weeks.

A convincing trial by the book

on-alcoholic steatohepatitis (the famous NASH11), itself heralding cirrhosis–point of no return for the liver. As in obesity and type 2 diabetes, the intestinal microbiota plays a frontline role. Hence the hope of countering this overdose of fat through probiotics: an avenue followed with success by research for around ten years. From animals to humans The first studies in animal models proved the benefits of using probiotics and prebiotics, and even synbiotics (a combination of the two). By way of example, the addition of fructooligosaccharides to probiotics led to a reduction in inflammation and in fatty particles in the liver, loss of weight and fat mass, and improved insulin sensitivity in some patients. These positive results were confirmed by the decrease in fat content of the liver in Hong Kong patients treated for six months with a mixture of lactobacilli and bifidobacteria. Decreased liver stiffness–a sign of diminished aggression–was observed in Iranian patients after taking synbiotics for twenty-eight weeks. A convincing trial by the book An additional step forward has been taken in establishing probiotics as a valid therapeutic option through a clinical trial conducted in a few dozen Ukrainian patients with non-alcoholic hepatic steatosis. The daily administration of a probiotic containing fourteen living strains over an eight week period produced a clear reduction in hepatic fat, some inflammatory markers and enzymes indicative of a diseased liver. These effects remain to be confirmed in a larger number of patients and over the long-term. But probiotics look very promising in the fight against these overdoses of fat for which our livers pay the price.

Sources

9 Kobyliak N, Abenavoli L, Mykhalchyshyn G, Kononenko L, Boccuto L, Kyriienko D, Dynnyk O. A Multi-strain. Probiotic Reduces the Fatty Liver Index, Cytokines and Aminotransferase levels in NAFLD Patients: Evidence from a Randomized Clinical Trial. J Gastrointestin Liver Dis. 2018 Mar;27(1):41-49.

10 Non-Alcoholic Fatty Liver Disease

11 Non-Alcoholic Steato-Hepatitis

Old sources

 

 

Tags
Probiotics

en_view en_sources

    See also

    Cholesterol-metabolizing gut bacteria?
    Bandeau_Article4_DTO Probiotics, a promising solution?
    Focus
    Diet and health: the role of the intestinal microbiota in metabolic diseases
    • A wide ranger of diseases
      • What are the links between intestinal microbiota and metabolic diseases?
      • Focus on diabetes
    • Diet: a key factor
      • Eating too much fat unbalances our intestinal flora
      • Diet and treatment: a history of microbial inequality
    • What are the therapeutic prospects?
      • Probiotics at the service of “fatty liver” syndrome
      • Fecal transplant: a promising route?
      • Expert interview : Pr Rémy Burcelin
    Created 26 September 2019
    Updated 30 December 2021

    About this article

    To know more about this topic.

    Main topic

    Diet

    Related microbiotas

    The gut microbiota

    Related topics

    Diet Probiotics
    Diet and treatment: a history of microbial inequality
    Fecal transplant: a promising route?
    Focus

    Diet and health: the role of the intestinal microbiota in metabolic diseases

    A wide ranger of diseases

    What are the links between intestinal microbiota and metabolic diseases? Focus on diabetes

    Diet: a key factor

    Eating too much fat unbalances our intestinal flora Diet and treatment: a history of microbial inequality

    What are the therapeutic prospects?

    Probiotics at the service of “fatty liver” syndrome Fecal transplant: a promising route? Expert interview : Pr Rémy Burcelin
    The power of your gut

    When bacteria and parasites attack the gut microbiota

    Viruses are not the only causes of diarrhea: there are other enteric pathogens (microorganisms infecting th...

    Find out more

    Expert Interview : Dr Julie Lemale

    Dr. Julie Lemale is a Pediatric Gastroenterologist at the Armand Trousseau Hospital (AP-HP, Paris) and a me...

    Find out more

    Diet: a key factor

    Viruses, bacteria, parasites: causes behind gastrointestinal infections are varied. The main associated sym...

    Find out more

    Diarrhea and use of antibiotics: case study

    Diarrhea is a common side effect of antibiotics, and it may compromise their efficacy, especially if the tr...

    Find out more

    Rotavirus and norovirus are to blame

    What causes these disorders? Among all infectious agents responsible for viral gastroenteritis, two viruses...

    Find out more

    What about the gut microbiota?

    The gut microbiota is a mix of microorganisms (bacteria, viruses, fungi…) making up a complex environment t...

    Find out more
    09.05.2022

    Is it normal that antibiotics give my child diarrhea?

    Read the article
    Obésité et microbiote : une bactérie aggrave l’effet d’une alimentation riche en graisses
    15.05.2023

    Obesity and microbiota: A bacterium worsens the effect of a high-fat diet

    Read the article
    My health, my microbiota
    Follow our Facebook page
    Our marvelous microbiota
    Get to understand our microbiota and the role they play in our body
    Find your dedicated section
    Healthcare professionals
    • Learn all about microbiota
      • The gut microbiota
      • The ENT microbiota
      • The pulmonary microbiota
      • The urinary microbiota
      • The skin microbiota
      • The vaginal microbiota
    • Microbiota and related conditions
      • Digestive disorders
      • Women disorders
      • Metabolic disorders
      • Skin disorders
      • Pediatric disorders
      • Psychiatric disorders
      • Neurological disorders
      • Respiratory disorders
      • Urinary disorders
    • Act on your microbiota
      • Probiotics
      • Prebiotics
      • Fecal Microbiota Transplant
      • Diet
    • Publications
      • News
      • Thematics folders
      • Thematic pages
      • Microbiota Q & A
      • Patients Stories
      • Experts' point of view
    • About the Institute
      • About us
      • International Microbiota Observatory
      • Press room
      • Partnerships

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube

    Healthcare professionals section

    Find here your dedicated section
    Biocodex logo
    The power of your gut
    My microbiota as a woman
    Our marvelous microbiota
    • English
    • Français
    • Español
    • Russian
    • Portuguese
    • Polish

    Browse the site

    • Learn all about microbiota
      • The gut microbiota
      • The ENT microbiota
      • The pulmonary microbiota
      • The urinary microbiota
      • The skin microbiota
      • The vaginal microbiota
    • Microbiota and related conditions
      • Digestive disorders
      • Women disorders
      • Metabolic disorders
      • Skin disorders
      • Pediatric disorders
      • Psychiatric disorders
      • Neurological disorders
      • Respiratory disorders
      • Urinary disorders
    • Act on your microbiota
      • Probiotics
      • Prebiotics
      • Fecal Microbiota Transplant
      • Diet
    • Publications
      • News
      • Thematics folders
      • Thematic pages
      • Microbiota Q & A
      • Patients Stories
      • Experts' point of view
    • About the Institute
      • About us
      • International Microbiota Observatory
      • Press room
      • Partnerships

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube

    Healthcare professionals section

    Find here your dedicated section
    Biocodex logo

    Discover

    The power of your gut
    My microbiota as a woman
    Our marvelous microbiota

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

    Healthcare professionals section

    Find here your dedicated section

    Redirection

    You are about to be redirected and leave our website

    • Be redirected
    • Stay on the Biocodex Microbiota Institute's website

    Stay with us !

    Join the microbiota community and receive "The Essentials" once a month to stay up to date with the latest news on the microbiota.

    * Mandatory Fields

    BMI 20-35

    Explore

    23.11.2023

    Antimicrobial resistance: Doctor, your role is essential! Patient, your behavior is key!

    Read the article
    15.11.2023

    Like to tan? Mind your skin microbiota!

    Read the article
    08.11.2023

    Microbiota imbalance at age one predicts allergies at age five

    Read the article

    Stay updated

    Join the Microbiota Community and receive once a month “The Essential” to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    • Learn all about microbiota
      • The gut microbiota
      • The ENT microbiota
      • The pulmonary microbiota
      • The urinary microbiota
      • The skin microbiota
      • The vaginal microbiota
    • Microbiota and related conditions
      • Digestive disorders
      • Women disorders
      • Metabolic disorders
      • Skin disorders
      • Pediatric disorders
      • Psychiatric disorders
      • Neurological disorders
      • Respiratory disorders
      • Urinary disorders
    • Act on your microbiota
      • Probiotics
      • Prebiotics
      • Fecal Microbiota Transplant
      • Diet
    • Publications
      • News
      • Thematics folders
      • Thematic pages
      • Microbiota Q & A
      • Patients Stories
      • Experts' point of view
    • About the Institute
      • About us
      • International Microbiota Observatory
      • Press room
      • Partnerships

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube

    Healthcare professionals section

    Find here your dedicated section
    Biocodex logo

    Discover

    The power of your gut
    My microbiota as a woman
    Our marvelous microbiota

    Healthcare professionals section

    Find here your dedicated section

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

    © 2022 Biocodex. All rights reserved.

    • Cookies Policy
    • Data protection policy
    • GTU
    • Sitemap
    • Cookies settings
    • Digital accessibility : partially compliant
    Biocodex logo