The urinary microbiota

The urinary microbiota: what is it and why is it so important for our health?

The human urinary tract is inhabited by numerous microorganisms that can play a protective role in our health.1 Reduced diversity in the urinary flora may also be a risk factor for disease.2 In fact, urine was once thought to be sterile, but recent scientific research has shown the opposite to be the case.2 Continue reading to see how research on the urinary microbiota is evolving.

Created 02 August 2021
Updated 01 October 2021

About this article

Created 02 August 2021
Updated 01 October 2021

Table of contents

Table of contents

What is exactly the human urinary microbiota?

You have probably heard less about the urinary microbiota than its more well-known neighbors, the gut microbiota and the vaginal microbiota. This is no surprise, since it is a less rich and diverse environment3 whose role requires further research.1

However, recent studies have shown that the urinary tract is home to a unique urinary microbiota.4,5 Urine analyses based on culture-dependent methods have traditionally identified (sidenote: Pathogens A pathogen is a microorganism that causes, or may cause, disease. Pirofski LA, Casadevall A. Q and A: What is a pathogen? A question that begs the point. BMC Biol. 2012 Jan 31;10:6. ) responsible for urinary tract infections (UTIs), such as Escherichia coli.

Advances in detection technologies have led to the discovery of additional bacteria in the urinary microbiota. The genus Lactobacillus is frequently identified, while Gardnerella, Streptococcus, and Corynebacterium also tend to be present, although to a lesser degree.3 In addition, communities of fungi have also been observed.6 

Moreover, although the number of studies in the area remains limited, the composition of the urinary microbiota of women appears to be different from that of men7, which is not surprising given the anatomical and hormonal differences between the two sexes.

Why is the urinary microbiota a key player in our health?

(sidenote: Microorganisms Living organisms that are too small to be seen with the naked eye. They include bacteria, viruses, fungi, archaea and protozoa, and are commonly referred to as “microbes”. ) inhabiting the urinary microbiota can play a protective role in our health1. However, under certain conditions, they can also influence urinary tract infections.2

Several mechanisms have been described: for example, the bacterial genera Lactobacillus and Streptococcus secrete lactic acid, which is believed to play a protective role against pathogens.8 Lactic acid lowers the pH of urine (≈ 4.5), creating a microenvironment that is hostile to most pathogenic bacteria.

Furthermore, Lactobacillus produces additional substances, antibacterial metabolites such as hydrogen peroxide, which also protect against pathogens.9 As with the gut microbiota, the urinary microbiota acts as a barrier against pathogens.1

What diseases are associated with an unbalanced urinary microbiota?

As with all microbiota (gut microbiota, lung microbiota, etc.), when the composition of the urinary microbiota is disrupted, an imbalance, or “ (sidenote: Dysbiosis Generally defined as an alteration in the composition and function of the microbiota caused by a combination of environmental and individual-specific factors. ) 9, results. Studies comparing the urinary microbiota of healthy subjects to that of patients suffering from various urinary diseases have identified a link between these diseases and the composition of the urinary microbiota.

In fact, studies published to date have demonstrated a clear role for the urinary microbiota in urinary tract infections (UTIs).8,10 For example, decreased diversity in the urinary microbiota may be a risk factor for urinary tract infections.11

Furthermore, disorders such as urgency urinary incontinence12, interstitial cystitis13, and sexually transmitted infections14 have also been associated with an altered urinary microbiota.

How can we take care of our microbiota? We can have a direct influence on it.

  • Diet: it is common knowledge that dietary factors can influence the risk of urinary tract infections. Certain food and dietary products (such as cranberry juice or fermented dairy products containing probiotics) may help reduce the risk of recurrent infection by regulating the microbiota.8

  • Probiotics: oral and vaginal probiotic have been successful in decreasing recurrence rates for (sidenote: Urinary Tract Infections ) .15

  • Water: drinking plenty of water is important, but researchers have not yet confirmed that it can cure UTIs.1

All the information in this article comes from scientific approved sources. Keep in mind this is not exhaustive. Here are all the studies from which we took all of that information.

References

Whiteside SA, Razvi H, Dave S, et al. The microbiome of the urinary tract--a role beyond infection. Nat Rev Urol. 2015 Feb;12(2):81-90.

2 Morand A, Cornu F, Dufour JC, et al. Human Bacterial Repertoire of the Urinary Tract: a Potential Paradigm Shift. J Clin Microbiol. 2019 Feb 27;57(3). 

Brubaker L, Wolfe AJ. The female urinary microbiota, urinary health and common urinary disorders. Ann Transl Med. 2017 Jan;5(2):34.

4 Hilt EE, McKinley K, Pearce MM, et al. Urine is not sterile: use of enhanced urine culture techniques to detect resident bacterial flora in the adult female bladder. J Clin Microbiol. 2014 Mar;52(3):871-6.

Pearce MM, Hilt EE, Rosenfeld AB, et al. The female urinary microbiome: a comparison of women with and without urgency urinary incontinence. mBio. 2014 Jul 8;5(4):e01283-14.

6 Ackerman AL, Underhill DM. The mycobiome of the human urinary tract: potential roles for fungi in urology. Ann Transl Med. 2017 Jan;5(2):31. 

Lewis DA, Brown R, Williams J, et al. The human urinary microbiome; bacterial DNA in voided urine of asymptomatic adults. Front Cell Infect Microbiol. 2013 Aug 15;3:41.

8 Aragón IM, Herrera-Imbroda B, Queipo-Ortuño MI, et al. The Urinary Tract Microbiome in Health and Disease. Eur Urol Focus. 2018 Jan;4(1):128-138. 

9 Levy M, Kolodziejczyk AA, Thaiss CA, et al. Dysbiosis and the immune system. Nat Rev Immunol. 2017;17(4):219-232

10 Antunes-Lopes T, Vale L, Coelho AM, et al. The Role of Urinary Microbiota in Lower Urinary Tract Dysfunction: A Systematic Review. Eur Urol Focus. 2020 Mar 15;6(2):361-369. 

11 Horwitz D, McCue T, Mapes AC, et al. Decreased microbiota diversity associated with urinary tract infection in a trial of bacterial interference. J Infect. 2015 Sep;71(3):358-367.

12 Pearce MM, Hilt EE, Rosenfeld AB, et al. The female urinary microbiome: a comparison of women with and without urgency urinary incontinence. mBio. 2014 Jul 8;5(4):e01283-14.

13 Siddiqui H, Lagesen K, Nederbragt AJ, et al. Alterations of microbiota in urine from women with interstitial cystitis. BMC Microbiol. 2012 Sep 13;12:205.

14 Nelson DE, Van Der Pol B, Dong Q, et al. Characteristic male urine microbiomes associate with asymptomatic sexually transmitted infection. PLoS One. 2010 Nov 24;5(11):e14116.

15 Stapleton AE, Au-Yeung M, Hooton TM, et al. Randomized, placebo-controlled phase 2 trial of a Lactobacillus crispatus probiotic given intravaginally for prevention of recurrent urinary tract infection. Clin Infect Dis. 2011 May;52(10):1212-7.

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