Microbiota and associated disorders

“ (sidenote: Dysbiosis Generally defined as an alteration in the composition and function of the microbiota caused by a combination of environmental and individual-specific factors. Levy M, Kolodziejczyk AA, Thaiss CA, et al. Dysbiosis and the immune system. Nat Rev Immunol. 2017;17(4):219-232.   ) ”, have you ever heard this word?

The dysbiosis is generally defined as an alteration in the composition and function of the microbiota caused by a combination of environmental and individual-specific factors1.
Many factors can disrupt the balance of our microbiota2.

This imbalance can have an impact on our health, and have been associated with a variety of diseases, such as diarrhea3, Crohn’s disease4, bacterial vaginosis5, atopic dermatitis6…

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    Disorders related to disruption of microbiota

    Digestive disorders

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    • Irritable bowel syndrome (IBS)
    • Antibiotics-associated diarrhea
    • Celiac disease
    • Gastroenteritis
    • IBD
    • Infantile colic
    • Stomach Cancer
    • Traveler's diarrhea
    • Food allergies
    • Functional gastrointestinal disorders

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    Metabolic disorders

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    • Obesity
    • Type 2 diabetes
    • Metabolic syndrome
    • Liver diseases

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    Women disorders

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    • Vaginal yeast infections
    • Bacterial vaginosis
    • Cystitis

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    Skin disorders

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    • Acne
    • Psoriasis
    • Allergic eczema

    Neurological disorders

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    • Alzheimer's disease
    • Parkison's disease
    • Autism-spectrum disorders

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    Psychiatric disorders

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    • Anxiety disorders
    • Mood disorders
    • Schizophrenia

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    Pediatric disorders

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    • Antibiotic-associated diarrhea
    • Gastroenteritis
    • Infantile colic

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    Respiratory disorders

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    • Allergic rhinitis
    • Winter respiratory infections
    • Asthma
    • Cystic fibrosis

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    Urinary disorders

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    • Cystitis
    • Prostatitis

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    Sources
    1. Levy M, Kolodziejczyk AA, Thaiss CA, et al. Dysbiosis and the immune system. Nat Rev Immunol. 2017;17(4):219-232.
    2. Hasan N, Yang H. Factors affecting the composition of the gut microbiota, and its modulation. PeerJ. 2019 Aug 16;7:e7502.
    3. McFarland LV. Antibiotic-associated Diarrhea: Epidemiology, Trends and Treatment. Future Microbiol. 2008 Oct;3(5):563-78.
    4. Bejaoui M, Sokol H, Marteau P. Targeting the Microbiome in Inflammatory Bowel Disease: Critical Evaluation of Current Concepts and Moving to New Horizons. Dig Dis. 2015;33 Suppl 1:105-112
    5. Greenbaum S, Greenbaum G, Moran-Gilad J, et al. Ecological dynamics of the vaginal microbiome in relation to health and disease. Am J Obstet Gynecol. 2019 Apr;220(4):324-335.
    6. Langan SM, Irvine AD, Weidinger S. Atopic dermatitis. Lancet. 2020 Aug 1;396(10247):345-360
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