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  3. From birth to death, an exposome with different consequences on our health
Our marvelous microbiota

From birth to death, an exposome with different consequences on our health

Exposome
The gut microbiota Acne and microbiota Diet: a key factor Mood disorders Food allergies

Our sensitivity to the environment changes throughout life. From pregnancy onward, the exposome shapes immunity, influences the infant’s microbiota, and affects their future risk of asthma or allergies. During adolescence, it impacts mental and skin health. In adulthood, it influences inflammation and overall well-being. In seniors, it can either preserve or impair longevity, as shown in studies on the microbiota of centenarians.

Discover how every stage of life interacts with the exposome.

The power of your gut
My microbiota as a woman
Our marvelous microbiota
  • Learn all about microbiota
    • The gut microbiota
    • The ENT microbiota
    • The pulmonary microbiota
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    • The exposome
  • Microbiota and related conditions
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About this article

Created 20 May 2025
Updated 01 July 2025

Table of contents

Table of contents

First 1,000 days

We’ve known for some time that the microorganisms in the gut microbiota are essential to the development of our immune system. However, other mechanisms related to early exposure of the fetus and young child to environmental factors may be involved 33. 

Gut microbiota: our immune system’s best friend 22.07.2022 Gut microbiota: our immune system’s best friend Read more

Perinatal period

  • Pregnancy: a mother’s  microbiota (gut, skin, lung, and perhaps placental microbiota) appears to have important effects on the maturation of the immune function in her offspring. For example, one study showed that exposing pregnant women to bacteria from barns reduced the risk of their children subsequently developing asthma. The placental  microbiota, which more closely resembles the maternal oral  microbiota than the vaginal or gut  microbiota, may play a role in this maturation.
  • Birth: babies born vaginally are colonized by microbes similar to those present in their mother’s vagina. They also have a richer and more diverse gut  microbiota than those born by Cesarean section, which is associated with a lower risk of asthma.
  • Breastfeeding

Other factors in the perinatal exposome (antibiotic treatment, breastfeeding, diet, etc.) are also thought to be involved.

Image
The following infographic shows you how and when the gut microbiota and the immune system are developed and become mature

Tiny bacteria, big risks: how vaginal microbes shape pregnancy health

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Early childhood

Since the middle of the last century, the trend towards more affluent lifestyles and more modern and “hygienic” habitats has altered our exposure to microbes. These alterations may predispose children to chronic inflammatory diseases.

Indeed, there’s strong evidence that early exposure to rich, diverse microbial populations plays a protective role, provided it occurs early in life. This period is known as the “window of opportunity”. 

08.11.2023 Microbiota imbalance at age one predicts allergies at age five Read more

Various studies have counter-intuitively shown that the presence of pets, rodents, fungi, or bacteria in the living environment of infants and toddlers improves the bacterial diversity of their  microbiota and may protect them from asthma. 

Dogs and dust microbiota in asthma prevention: a masterstroke?

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Childhood and adolescence 

The value of the exposomic approach was highlighted by a study of 504 children aged 6 to 9, who were followed for eight years. Researchers measured the impact of different exposures (diet, physical activity, sleep, air pollution, socio-economic status) on blood markers (metabolites).

Exposome score

For each child, the researchers calculated an “exposome score” measuring the overall impact of various exposures on health. 

The results show that this score is associated with 31 metabolites, 12 of which were not linked to any individual exposure. This indicates that environmental and lifestyle exposures do not exert their physiological effects in isolation. 

Rather, there’s a complex interaction between external exposures and the associated internal physiological responses.

What’s more, a high exposome score is associated with lower levels of acetate, a (sidenote: Short chain fatty acids (SCFA) Short chain fatty acids (SCFA) are a source of energy (fuel) for an individual’s cells. They interact with the immune system and are involved in communication between the intestine and the brain. Silva YP, Bernardi A, Frozza RL. The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication. Front Endocrinol (Lausanne). 2020;11:25. ) produced by the gut microbiota. Studies suggest that acetate may play a beneficial role in metabolic, cardiovascular, and neuronal health 34 . 

After all, eating Big Brother's snot might not be a bad idea

Learn more

Acne

Another study, this time on teenagers, showed that numerous lifestyle factors (consumption of skimmed milk and whey protein supplements, stress, pollutants, medication, climate factors, etc.) had a clear impact on the progression and severity of acne, and on the efficacy of treatments. 

Skin care products and cosmetics are part of the external exposome. They can activate inflammation and cause acne flare ups by altering the skin barrier and the balance of the skin  microbiota, promoting sebum secretion, modifying microbes, and activating the innate immune system 35. 

28.08.2019 Severe acne: what role does the skin microbiota play? Read more

Mental health

We also know that during adolescence, stress – often more intense than at other times of life – and the increased production of androgens (such as testosterone) are likely to modify the  microbiota and, consequently, the gut-brain axis. 

Research suggests that these internal exposome changes may play a role in the emergence of psychiatric illnesses, many of which first appear during adolescence 36. 

Image

What role does the microbiota play in the gut-brain axis?

Learn more

Adulthood 

It’s becoming increasingly clear that the gut microbiota is involved in various aspects of physical and mental well-being, and that its structure and function largely depend on lifestyle. 

While the impact of the exposome is crucial early in life, we know that its harmful effects can continue into adulthood. A Western diet (low in fruit, vegetables, and whole grains; high in animal products and ultra-processed foods) can, for example, disrupt the biofilm and gut barrier, making the gut more permeable. 

15.01.2024 The surprising source of your gut bacteria? It could be your next salad! Read more

This can allow pieces of bacteria (endotoxins or lipopolysaccharides) to enter the bloodstream, leading to chronic low-grade inflammation, with potentially harmful metabolic and behavioral consequences. Conversely, a diet rich in fiber and phytochemicals from plants can promote microbial diversity and reduce oxidative stress and inflammatory load. 

13.06.2024 Resistant starch: a superfood that reshapes gut microbiota and boosts weight loss! Read more

An unbalanced diet combined with stress, a lack of contact with nature, a microbe-poor environment, and a lack of outdoor physical activity can also alter the microbial diversity of the gut and skin  microbiota. A lessdiverse  microbiota means immune dysfunction and chronic inflammation, which can affect all organs and pave the way for chronic disease.  

How to keep a healthy microbiota?

Learn more

Among seniors

Aging is generally associated with alterations in the gut  microbiota. Over time, the gut microbiota tends to lose its diversity and balance (dysbiosis), contributing to an accentuation of inflammatory processes and increased susceptibility to diseases that make the elderly more fragile. 

Image

On the other hand, maintaining a balanced  microbiota over time promotes a healthy metabolism and immune system, and preserves heart, bone, and cognitive health. 

While the causes of  microbiota alterations with age are still under research, the study of centenarians’  microbiota tells us that certain exposome factors may be involved. 

26.05.2021 Is the gut microbiota a good indicator of longevity? Read more

Eating habits, such as adherence to the Mediterranean diet (rich in fiber and antioxidants), are correlated with gut microbial species linked to longevity 38,39. Physical activity, not smoking, and satisfactory working conditions may also play a part.

Read the rest of the article

Towards a more favorable exposome

Continue reading

Back to previous page

Exposure to air pollution disturbs the microbiota of babies 20.05.2025 Microbiota under pressure: how the exposome promotes chronic disease Read more
Sources

1. Renz H, Holt PG, Inouye M, et al. An exposome perspective: Early-life events and immune development in a changing world. J Allergy Clin Immunol. 2017 Jul;140(1):24-40.

2. Healy DR, Zarei I, Mikkonen S, et al. Longitudinal associations of an exposome score with serum metabolites from childhood to adolescence. Commun Biol. 2024 Jul 22;7(1):890.

3. Dréno B, Bettoli V, Araviiskaia E, et al. The influence of exposome on acne. J Eur Acad Dermatol Venereol. 2018 May;32(5):812-819.

4. McVey Neufeld SF, Ahn M, Kunze WA, McVey Neufeld KA. Adolescence, the Microbiota-Gut-Brain Axis, and the Emergence of Psychiatric Disorders. Biol Psychiatry. 2024 Feb 15;95(4):310-318.

5. Renz H, Holt PG, Inouye M, et al. An exposome perspective: Early-life events and immune development in a changing world. J Allergy Clin Immunol. 2017 Jul;140(1):24-40.

6. Buettner D, Skemp S. Blue Zones: Lessons From the World's Longest Lived. Am J Lifestyle Med. 2016 Jul 7;10(5):318-321

7. Pang S, Chen X, Lu Z et al. Longevity of centenarians is reflected by the gut microbiome with youth-associated signatures. Nat Aging. 2023 Apr;3(4):436-449.

Tags
Exposome Nature Environment Microbiome Flora Baby Senior Gut-brain axis Immunity Aging Teenagers Mood disorders Allergies Food allergies

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