Mood disorders

Depression and bipolar disorder indicate a mood disorder. Beyond classic psychiatric treatments, research is in progress to evaluate the impact of intestinal microbiota on these disorders.

Created 15 October 2020
Updated 03 November 2021

About this article

Created 15 October 2020
Updated 03 November 2021

Mood disorders are common: 300 million people in the world suffer from depression and 60 million have bipolar disorder.These disorders cause mental distress that can often be severe, which can lead to suicide. They are the #1 cause of professional and social disability in the world.

Inappropriate stress response

Each individual has their own vulnerability to depression or bipolar disorder, which is in part genetic.As a result, during unpleasant life events, some people experience an excessive response, with overly elevated secretion of the stress hormones cortisol and adrenaline. This situation can lead to nervous exhaustion and favor the onset of a depressive state. Recent research has also documented the role of intestinal flora (microbiota) in these inappropriate stress responses. Indeed in animals, microbiota participates in the regulation of emotions through communication between the intestine and the brain. In the case of dysbiosis (disruptions in the composition of the microbiota), this regulation is less effective and favors the onset of mood disorders.

A new avenue for treatment

Beyond classic treatments (antidepressants, mood regulators, psychotherapy, etc.), a new avenue is opening: rebalancing the microbiota to influence mood. A recent study also showed that taking probiotics daily, a combination of lactobacilli and bifidobacteria, improved mood and reduced the level of anxiety in healthy subjects.


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