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Gynecology

Vaginal microbiota #14

Period
Gynecology

By Pr. Markku Voutilainen
Turku University Faculty of Medicine; Turku University Hospital, Department of Gastroenterology, Turku, Finland

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Created 15 December 2021
Updated 20 January 2022

Is the vaginal microbiota to blame for dysmenorrhea?

Chen CX, Carpenter JS, Gao X, et al. Associations Between Dysmenorrhea Symptom Based Phenotypes and Vaginal Microbiome: A Pilot Study. Nurs Res 2021 [Epub ahead of print].

In a pilot study - the first to focus on the link between the composition of the vaginal microbiota during menstruation and the intensity of period pain - 20 women were classified into three groups accordingto the pain they experienced during their period: “mild localized pain”, “severe localized pain”, or “severe multiple pain and gastrointestinal symptoms”. The vaginal microbiota was analyzed both during menstruation and outside of menstruation. The results showed that the vaginal microbiota composition significantly varied between women as well as over the course of the menstrual cycle, but the composition during menstruation varied even more depending on intensity of pain. In particular, during menstruation, women with more severe dysmenorrhea had a
lower abundance of lactobacilli and a higher abundance of potentially pro inflammatory bacteria. Although limited in terms of size, age groups studied and ethnic diversity, this pilot study is a first step towards larger studies on associations between the intensity of pain during menstruation and the composition of the vaginal microbiota. The researchers hypothesize that during menstruation endometrial tissue is broken down, releasing compounds (prostaglandins) that may cause uterine muscle contractions and increased sensitivity, thus contributing to menstrual pain. Certain bacteria in the vaginal microbiota may promote the release of these compounds and of pro-inflammatory cytokines that exacerbate the symptoms of dysmenorrhea. If these hypotheses are confirmed, the pilot study would underline the importance of taking into account inter-individual differences and the dynamics of the vaginal microbiota during the menstrual cycle.

Cervicovaginal microbiota: a marker for persistent papillomavirus infection?

Qingqing B, Jie Z, Songben Q, et al. Cervicovaginal microbiota dysbiosis correlates with HPV persistent infection. Microb Pathog 2020; 152: 104617.

In this new study, the cervicovaginal microbiota of 15 women was analyzed via 16S rRNA gene sequencing, and HPV genotyping was performed. Six of the women showed persistent infection (infection with the same HPV type for more than 12 months), four showed transient infection (infection cleared in less than 12 months) and five were HPV-negative. The three groups showed significant differences in the composition of the cervicovaginal microbiota. In the healthy women and those with transient infection, the Lactobacillus genus predominated, whereas women with persistent infection had a more diverse cervicovaginal microbiota. A statistical analysis revealed 36 bacteria to be associated with transient or persistent infection status, with these bacteria having the potential to serve as biomarkers. Among them, and in line with previous studies, the genera Acinetobacter, Prevotella and Pseudomonas were correlated with persistent infection. On the other hand, Lactobacillus iners was correlated with transient infection. The women with persistent HPV infection had significantly higher concentrations of IL-6 and TNF-α in their cervical secretions and a higher number of regulatory T cells and myeloid-derived suppressor cells in their peripheral blood. The results of this study suggest that changes in the cervicovaginal microbiota may be linked to persistent HPV infection. However, it is not known whether dysbiosis induces persistence of the infection or vice versa. Despite this, the identification of a microbial signature for persistent HPV infection may allow earlier diagnosis, ultimately leading to earlier intervention to eradicate the infection and reduce the likelihood of developing malignant cervical lesions.

Tags
Vaginal microbiota Period Dysmenorrhea Papillomavirus Lactobacillus

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    Focus
    Microbiota 14 - December 2021
    • Overview
      • Plausibility of a pathophysiological role for altered gut microbiota in the irritable bowel syndrome
      • Could the gut microbiome be targeted to optimized SARS-CoV-2 vaccine efficacy?
    • Commented article
      • Gut-microbiota-targeted diets modulate human immune status
      • Ethnicity associations with food sensitisation are mediated by gut microbiota development in the first year of life
    • Congress Review
      • Highlights from the APDW 2021
      • Highlights from the UEG week 2021
    • Press Review
      • Gut microbiota #14
      • Vaginal microbiota #14
    Created 15 December 2021
    Updated 20 January 2022

    About this article

    To know more about this topic.

    Main topic

    Period

    Medical practice

    Gynecology

    Content type

    Press review
    Gut microbiota #14
    Focus

    Microbiota 14 - December 2021

    Overview

    Plausibility of a pathophysiological role for altered gut microbiota in the irritable bowel syndrome Could the gut microbiome be targeted to optimized SARS-CoV-2 vaccine efficacy?

    Commented article

    Gut-microbiota-targeted diets modulate human immune status Ethnicity associations with food sensitisation are mediated by gut microbiota development in the first year of life

    Congress Review

    Highlights from the APDW 2021 Highlights from the UEG week 2021

    Press Review

    Gut microbiota #14 Vaginal microbiota #14
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