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Our marvelous microbiota

Antibiotic resistance genes float in the clouds

Antibiotics
The gut microbiota

Antibiotic resistance is a major public health concern that reaches the whole world... including by air. Large quantities of genes from antibiotic-resistant bacteria have been found in clouds. As they spread into the atmosphere, they can travel long distances.

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About this article

Created 29 August 2023
Updated 02 May 2024

The fact that bacteria adapt to resist antibiotics is a natural evolutionary phenomenon. But the massive use of these drugs to treat human, animal and plant infections has greatly amplified it. And every year, a good proportion of the tons of antibiotics used end up in the environment, namely in soil, rivers, oceans, etc. Resistant bacteria can develop there, transmit their resistance genes to other bacteria and disperse with the wind and reach high altitudes. Although the atmosphere is not a suitable environment for their survival, fragments and genetic material can still reach the clouds, travel from one continent to another and return to dry land through rain.

Bacterial resistance to antibiotics is a public health issue

Antibiotic resistance has been ranked as one of the top 10 threats to human health in the near future. In 2019, nearly five million deaths were linked to antimicrobial resistance and almost 1.3 million were directly attributed to antibiotic-resistant infections. If nothing is done, 10 million people could die by 2050, making antibiotic resistance the world's leading cause of death. 

Clouds vacuumed up into test tubes

At the Puy-de-Dôme weather station located at an altitude of 1,465 meters in the French Massif Central, Franco-Canadian researchers spent two years taking 12 "cloud samples" with a special vacuum cleaner aimed at nimbus and cumulus clouds. For each sample, they measured the quantity of bacteria and 33 resistance genes corresponding to the main antibiotics used today. Of these, 29 were detected at least once and 6 were observed in at least 75% of the samples. The clouds contained an average of 8,000 bacteria mainly of plant origin, of which 5 to 50% could be alive and potentially active, and over 20,000 copies of antibiotic resistance genes per milliliter of water.1,2

Nature and microbiota: how does it affect your health? 08.07.2022 Nature and microbiota: how does it affect your health? Read more

The researchers found that the distribution of these genes varied according to the geographical origin of the air masses sampled. For example, genes for resistance to quinolones (antibiotics whose use has been restricted for several years due to the antibiotic resistance they promote) were more abundant in high ocean clouds. Sulfonamide and tetracycline resistance genes were more prevalent in clouds formed over continental surfaces, perhaps due to their widespread use in livestock farming.

Reservoirs of antibiotic resistance genes hovering over our heads

The researchers extrapolated their measurements to the total volume of clouds around the earth, assuming that all would have the same concentration of antibiotic resistance genes. The results showed that every year, around 70 trillions of trillions (1024) of these genes pass through the clouds, of which around 3% could potentially fall back down to the earth's surface.

This study highlights the role of the atmosphere as one of the routes by which antibiotic resistance factors are disseminated worldwide. Additional studies to pinpoint the sources of bacterial emissions could help limit their dispersion.

What is the World AMR Awareness Week?

Each year, since 2015, the WHO organizes the World AMR Awareness Week (WAAW), which aims to increase awareness of global antimicrobial resistance.

Antimicrobial resistance occurs when bacteria, viruses, parasites and fungi change over time and no longer respond to medicines. As a result of drug resistance, antibiotics and other antimicrobial medicines become ineffective and infections become increasingly difficult or impossible to treat, increasing the risk of disease spread, severe illness and death.
Held on 18-24 November, this campaign encourages the general public, healthcare professionals and decision-makers to use antibiotics, antivirals, antifungals and antiparasitics carefully, to prevent the further emergence of antimicrobial resistance.

Sources

1. Rossi F, Péguilhan R, Turgeon N, et al. Quantification of antibiotic resistance genes (ARGs) in clouds at a mountain site (puy de Dôme, central France). Sci Total Environ. 2023;865:161264

2. Université Laval : Scientists discover antibiotic resistance genes in clouds (27 avril 2023) https://pressroom.ulaval.ca/2023/04/27/scientists-discover-antibiotic-resistance-genes-in-clouds-nbsp-a:2f391f81-f319-4f15-9aca-11365f6b30db

Tags
Antibiotic resistance Environment Air explore Antibiotics Microbiome Flora

    See also

    6 things you should know about antibiotics
    Antibiotics: what impact on the microbiota and on our health? Antibiotics: what impact on the microbiota and on our health?
    Created 29 August 2023
    Updated 02 May 2024

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