Public Area
Access Pro

Stomach cancer

Colorectal cancer and stomach cancer are two gastrointestinal cancers whose origins are most probably influenced by the intestinal microbiota. 

Colorectal cancer, the importance of environmental factors 

With 694,000 deaths per year around the world, colorectal cancer is the 2nd most deadly cancer. Genetic factors are a significant but minority cause of gastrointestinal cancer, which is most heavily attributed to environmental factors such as sedentary lifestyle, obesity, and, in particular unbalanced diet, which causes intestinal dysbiosis. Furthermore, the hypothesis of an imbalance between harmful and beneficial bacterial species with regard to this cancer is more than likely.

Colorectal cancer doesn’t show any symptoms for a long time, then manifests by persistent or sudden problems with intestinal transit: constipation, diarrhea, the pressing need to go, etc. 

Examining the stool for blood and colonoscopy are the two primary methods for detecting colorectal cancer.

Surgery forms the basis of treatment via the removal of part of the colon, sometimes supplemented with chemotherapy or radiation therapy. 

Bacteria responsible in 80% of stomach cancers

Although various risk factors have been identified (smoking, diet, family history, genetic predisposition), the primary cause of stomach cancer is Helicobacter pylori a pathogenic bacteria that causes chronic gastritis.

The symptoms are not very specific: stomach pain, repeated nausea and vomiting, and a change in general state. Only endoscopy of the stomach and esophagus can confirm the diagnosis.

Surgery is the reference treatment for localized tumors, with partial or total removal of the stomach. For locally advanced forms, physicians also add chemotherapy.

Restoring the microbiota, therapy of the future?

Since the existence of a connection between bacteria and gastrointestinal cancers seems more than likely, manipulating the microbiota with probiotics and prebiotics is being studied as a potential therapeutic treatment.  

Digestive system disruption

  • DAA

    Antibiotics can cause diarrhea during treatment or in the two months after the end of treatment. Although it is generally benign, this post-...
  • Functional gastrointestinal disorders

    Functional gastrointestinal disorders (FGDs), the most common intestinal afflictions, are a collection of chronic digestive symptoms that ar...
  • IBD

    Inflammatory bowel diseases (IBDs) include Crohn’s disease and ulcerative colitis. These diseases don’t have an effect on life expectancy, b...
  • Traveler's diarrhea

    Traveler’s diarrhea (or “turista”) is a generally benign infection, most often caused by bacteria, which temporarily disturbs intestinal mic...
  • Gastroenteritis

    Gastroenteritis, the primary cause of death in developing countries, is, in Western countries, generally benign and most often viral. Beyond...
  • Celiac disease

    Celiac disease is an autoimmune digestive disease caused by a gluten intolerance. Various factors are at work, including an imbalance in the...