Skip to main content
About the Institute
  • English
  • Français
  • Español
  • Russian
  • Portuguese
  • Polish

Breadcrumb

  1. Home
  2. The power of your gut
  3. Obesity: beware of B vitamin deficiency!
  • Learn all about microbiota
    • The gut microbiota
    • The ENT microbiota
    • The pulmonary microbiota
    • The urinary microbiota
    • The skin microbiota
    • The vaginal microbiota
  • Microbiota and related conditions
    • Digestive disorders
    • Women disorders
    • Metabolic disorders
    • Skin disorders
    • Pediatric disorders
    • Psychiatric disorders
    • Neurological disorders
    • Respiratory disorders
    • Urinary disorders
  • Act on your microbiota
    • Probiotics
    • Prebiotics
    • Fecal Microbiota Transplant
    • Diet
  • Publications
    • News
    • Thematics folders
    • Thematic pages
    • Microbiota Q & A
    • Patients Stories
    • Experts' point of view
  • About the Institute
    • About us
    • International Microbiota Observatory
    • Press room
    • Partnerships

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube
    • Instagram
    • Bluesky

Healthcare professionals section

Find here your dedicated section
Biocodex logo
The power of your gut
My microbiota as a woman
Our marvelous microbiota

Breadcrumb

  1. Home
  2. The power of your gut
  3. Obesity: beware of B vitamin deficiency!
The power of your gut

Obesity: beware of B vitamin deficiency!

Obesity
The gut microbiota Obesity Diet Prebiotics: what you need to know

Contrary to popular belief, obesity is not necessarily synonymous with excess. Vitamin B7 (biotin) deficiencies can trigger a vicious circle between gut bacteria and obesity. Explanation. 

The power of your gut
My microbiota as a woman
Our marvelous microbiota
  • Learn all about microbiota
    • The gut microbiota
    • The ENT microbiota
    • The pulmonary microbiota
    • The urinary microbiota
    • The skin microbiota
    • The vaginal microbiota
  • Microbiota and related conditions
    • Digestive disorders
    • Women disorders
    • Metabolic disorders
    • Skin disorders
    • Pediatric disorders
    • Psychiatric disorders
    • Neurological disorders
    • Respiratory disorders
    • Urinary disorders
  • Act on your microbiota
    • Probiotics
    • Prebiotics
    • Fecal Microbiota Transplant
    • Diet
  • Publications
    • News
    • Thematics folders
    • Thematic pages
    • Microbiota Q & A
    • Patients Stories
    • Experts' point of view
  • About the Institute
    • About us
    • International Microbiota Observatory
    • Press room
    • Partnerships

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube
    • Instagram
    • Bluesky

Healthcare professionals section

Find here your dedicated section
Biocodex logo

Sources

This article is based on scientific information

Sharing is caring

Your friends might be interested in this topic. Why not share it?

  • Facebook
  • Twitter
  • Mail
Obesity isn't just excess

About this article

Created 15 April 2022
Updated 16 August 2024

Although we need only very small quantities, vitamins are no less essential to our health—if we do not get enough vitamin C, for example, we can develop scurvy, a disease from which many sailors died when a lemon would have been enough to save them. To a lesser extent, cognitive disorders, numbness or a persistent state of fatigue can also be signs of a vitamin B deficiency. Moreover, the etymology of the word reveals something of its “vital function”: “vitamin” comes from the Latin “vita,” meaning life.

The B7 engine

Among the many vitamins essential for our body to function properly are the B vitamins, including the famous vitamin B7, also called (sidenote: Biotin Called vitamin B7, or B8 in certain countries. This vitamin plays a key role in the metabolism of carbohydrates, lipids and amino acids. It is also involved in the biosynthesis of other vitamins (B9 and B12). Many foods are good sources of biotin (whole grains, eggs, milk, nuts, etc.). This vitamin is also synthesized by the bacteria in gut flora. Biotin_NIH National Cancer Institut ) . One of our main sources of biotin is food, but that’s not all! The bacteria in gut microbiota also produce it... or not, as the case may be. And this has consequences for our health, especially in the case of obesity.

x11 Severe obesity increased 11-fold in men

x3 and 3-fold in women worldwide between 1975 and 2014.

The vicious circle of obesity

A team of researchers has just shown that the gut bacteria that produce and transport biotin are absent in severely obese patients ( (sidenote: Body Mass Index (BMI) Body Mass Index (BMI) assesses the corpulence of an individual by estimating the body fat mass calculated by a ratio between weight ((kg) and height squared (m2). https://www.nhlbi.nih.gov/health/educational/lose_wt/BMI/bmicalc.htm https://www.euro.who.int/en/health-topics/disease-prevention/nutrition/a-healthy-lifestyle/body-mass-index-bmi ) > 35). Their obese host is thus deprived of this additional non-dietary source, despite actually needing more than the average person (vitamin B being necessary for well-balanced adipose tissue). Experiments in animals show that the (sidenote: Western diet Diet rich in processed foods, refined sugar, salt, saturated fats (red meats) and trans fats (pastries) Zinöcker MK, Lindseth IA. The Western Diet-Microbiome-Host Interaction and Its Role in Metabolic Disease. Nutrients. 2018 Mar 17;10(3):365.  ) , well known for promoting obesity, reduces both the quantity of biotin-producing gut bacteria and the circulating levels of this vitamin in serum. Also, paradoxically, the gut inflammation observed in obese patients limits the absorption of biotin supplied by the diet.

In cases of severe obesity, a vicious circle is thus set in motion, since gut dysbiosis is believed to aggravate inflammation (and obesity) as well as tissue biotin deficiency.

03.08.2021 Obesity Read more
03.11.2021 Have you heard of "dysbiosis"? Read more

Boosting biotin production

How can we break this vicious circle? Weight-loss surgery (bariatric surgery), which improves metabolism and inflammation, stimulates growth of biotin-producing bacteria, resulting in an increase—at least during the first year—in the level of biotin circulating in the body. Another approach involves supplementing with prebiotics (fructo-oligosaccharide type fibers) and biotin. This has been tested in mice fed a high-fat diet, and was found to improve the diversity of gut microbiota and boost bacterial production of biotin and other B vitamins, while limiting weight gain and deterioration of blood sugar levels.

The gut microbiota

Find out more

Recommended by our community

"Interesting" - Christine Lange (From My health, my microbiota) 

Sources

NCD Risk Factor Collaboration (NCD-RisC). Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants. Lancet. 2016;387:1377–96

Belda E, Voland L, Tremaroli V et al. Impairment of gut microbial biotin metabolism and host biotin status in severe obesity: effect of biotin and prebiotic supplementation on improved metabolism. Gut. 2022 Jan 11:gutjnl-2021-325753.

Tags
Obesity Weight Vitamines Prebiotics Microbiome Flora

    See also

    Is there a link between gut microbiota and weight?
    Actu GenPu: L’avocat, mon partenaire minceur ? Can avocados help us lose weight?
    Created 15 April 2022
    Updated 16 August 2024

    About this article

    To know more about this topic.

    Main topic

    Obesity

    Related microbiotas

    The gut microbiota

    Related topics

    Obesity Diet Prebiotics: what you need to know
    The power of your gut

    Microbiotalk : short conferences on antimicrobial resistance

    Breaking the silence: a global conversation on antimicrobial resistance Antimicrobial resistance (AM...

    Find out more

    Functional dyspepsia

    Despite its strange-sounding name, functional dyspepsia is a common digestive disorder. Characteristi...

    Find out more

    The gut microbiota

    Gut microbiota: why is it that important for your health? We have trillions1 of bacteria that po...

    Find out more

    Travelers’ diarrhea

    It's not what you think... Notice to globetrotters and travelers who’ve fallen victim to the dreaded...

    Find out more

    Fecal transplant: a promising route?

    This will surprise more than one person: using stool for therapeutic purposes did not start yesterday...

    Find out more

    Expert Interview : Dr Julie Lemale

    Dr. Julie Lemale is a Pediatric Gastroenterologist at the Armand Trousseau Hospital (AP-HP, Paris) an...

    Find out more

    Probiotics, a promising solution?

    Probiotics are “live microorganisms (bacteria, yeasts) that, upon ingestion in sufficient concentrati...

    Find out more

    Expert interview : Pr Patrice D. Cani

    Modulating the gut microbiota: effective for losing weight? While the study of gut microbiota opens ...

    Find out more

    Latest news

    News
    13.05.2025

    When sodas harm your microbiota and your health

    Read the article
    07.05.2025

    Downside of fruit and vegetable juices for gut health

    Read the article
    Allergies : et si tout venait du microbiote ?
    28.03.2023

    Allergies: and what if it all started with the microbiota?

    Read the article
    Photo LP: Sensibles à l’E466 ? Votre microbiote a son mot à dire
    15.04.2025

    Sensitive to E466? Your microbiota plays a role

    Read the article
    23.04.2024

    Bacterial diarrhea: the only case where antibiotics can be used

    Read the article
    Patients stories - logo
    21.11.2022

    Patients stories: living with Irritable Bowel Syndrome (IBS)

    Read the article
    Actu GP : Bière sans alcool, le microbiote intestinal en raffole !
    15.10.2019

    Non-alcoholic beer: the gut microbiota just loves it!

    Read the article
    Actu GP : Le régime méditerranéen contre la fragilité des seniors ?
    28.05.2020

    Does the Mediterranean diet protect the elderly against frailty?

    Read the article
    • Learn all about microbiota
      • The gut microbiota
      • The ENT microbiota
      • The pulmonary microbiota
      • The urinary microbiota
      • The skin microbiota
      • The vaginal microbiota
    • Microbiota and related conditions
      • Digestive disorders
      • Women disorders
      • Metabolic disorders
      • Skin disorders
      • Pediatric disorders
      • Psychiatric disorders
      • Neurological disorders
      • Respiratory disorders
      • Urinary disorders
    • Act on your microbiota
      • Probiotics
      • Prebiotics
      • Fecal Microbiota Transplant
      • Diet
    • Publications
      • News
      • Thematics folders
      • Thematic pages
      • Microbiota Q & A
      • Patients Stories
      • Experts' point of view
    • About the Institute
      • About us
      • International Microbiota Observatory
      • Press room
      • Partnerships

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube
      • Instagram
      • Bluesky

    Healthcare professionals section

    Find here your dedicated section
    Biocodex logo
    The power of your gut
    My microbiota as a woman
    Our marvelous microbiota
    • English
    • Français
    • Español
    • Russian
    • Portuguese
    • Polish

    Browse the site

    • Learn all about microbiota
      • The gut microbiota
      • The ENT microbiota
      • The pulmonary microbiota
      • The urinary microbiota
      • The skin microbiota
      • The vaginal microbiota
    • Microbiota and related conditions
      • Digestive disorders
      • Women disorders
      • Metabolic disorders
      • Skin disorders
      • Pediatric disorders
      • Psychiatric disorders
      • Neurological disorders
      • Respiratory disorders
      • Urinary disorders
    • Act on your microbiota
      • Probiotics
      • Prebiotics
      • Fecal Microbiota Transplant
      • Diet
    • Publications
      • News
      • Thematics folders
      • Thematic pages
      • Microbiota Q & A
      • Patients Stories
      • Experts' point of view
    • About the Institute
      • About us
      • International Microbiota Observatory
      • Press room
      • Partnerships

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube
      • Instagram
      • Bluesky

    Healthcare professionals section

    Find here your dedicated section
    Biocodex logo

    Discover

    The power of your gut
    My microbiota as a woman
    Our marvelous microbiota

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube
    • Instagram
    • Bluesky

    Healthcare professionals section

    Find here your dedicated section

    Redirection

    You are about to be redirected and leave our website

    • Be redirected
    • Stay on the Biocodex Microbiota Institute's website

    Stay with us !

    Join the microbiota community and receive "The Essentials" once a month to stay up to date with the latest news on the microbiota.

    * Mandatory Fields

    BMI 20-35

    Explore

    13.05.2025

    When sodas harm your microbiota and your health

    Read the article
    07.05.2025

    Downside of fruit and vegetable juices for gut health

    Read the article
    Photo LP: Sensibles à l’E466 ? Votre microbiote a son mot à dire
    15.04.2025

    Sensitive to E466? Your microbiota plays a role

    Read the article

    Stay updated

    Join the Microbiota Community and receive once a month “The Essential” to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    • Learn all about microbiota
      • The gut microbiota
      • The ENT microbiota
      • The pulmonary microbiota
      • The urinary microbiota
      • The skin microbiota
      • The vaginal microbiota
    • Microbiota and related conditions
      • Digestive disorders
      • Women disorders
      • Metabolic disorders
      • Skin disorders
      • Pediatric disorders
      • Psychiatric disorders
      • Neurological disorders
      • Respiratory disorders
      • Urinary disorders
    • Act on your microbiota
      • Probiotics
      • Prebiotics
      • Fecal Microbiota Transplant
      • Diet
    • Publications
      • News
      • Thematics folders
      • Thematic pages
      • Microbiota Q & A
      • Patients Stories
      • Experts' point of view
    • About the Institute
      • About us
      • International Microbiota Observatory
      • Press room
      • Partnerships

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube
      • Instagram
      • Bluesky

    Healthcare professionals section

    Find here your dedicated section
    Biocodex logo

    Discover

    The power of your gut
    My microbiota as a woman
    Our marvelous microbiota

    Healthcare professionals section

    Find here your dedicated section

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube
    • Instagram
    • Bluesky

    © 2025 Biocodex. All rights reserved.

    • Legal notice
    • GTU
    • Data protection policy
    • Sitemap
    • Cookies settings
    • Digital accessibility : partially compliant
    Biocodex logo