Skip to main content
About the Institute
  • English
  • Français
  • Español
  • Russian
  • Portuguese
  • Polish

Breadcrumb

  1. Home
  2. Gastroenterology
  3. Aspirin: antibiotic effect in colorectal cancer?
  • Our publications
    • News
    • Microbiota Mag
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • Partnerships
    • Press room
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
    • Xpeer App
  • Useful documents
    • Infographics
    About the Institute

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

Lay public section

Find here your dedicated section
Gastroenterology
Gynecology
Pediatrics
Dermatology

Breadcrumb

  1. Home
  2. Gastroenterology
  3. Aspirin: antibiotic effect in colorectal cancer?
Gastroenterology

Aspirin: antibiotic effect in colorectal cancer?

Cancer
Gastroenterology Oncology

Known for its anti-inflammatory effects, aspirin also acts as an antibiotic on certain bacteria involved in colorectal cancer. It may even prevent tumorigenesis, both in vitro and in vivo.

Gastroenterology
Gynecology
Pediatrics
Dermatology
  • Our publications
    • News
    • Microbiota Mag
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • Partnerships
    • Press room
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
    • Xpeer App
  • Useful documents
    • Infographics
    About the Institute

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

Lay public section

Find here your dedicated section

Sources

This article is based on scientific information

Sharing is caring

Your colleagues might be interested in this topic. Why not share it?

  • Facebook
  • Twitter
  • LinkedIn
  • Mail

About this article

Created 16 November 2021
Updated 18 January 2022

There is increasing understanding of the clinical correlations and potential mechanistic roles of specific members of the gut and tumoral microbiota in colorectal cancer (CRC) initiation, progression, and survival. Despite this, we are still a long way from defining microbially-informed diagnostic, preventive, or therapeutic approaches. However, a step forward has just been made, with a team recently showing that aspirin, a chemopreventive agent recommended by the (sidenote: United States Preventive Services Task Force An independent, volunteer panel of US experts in disease prevention and evidence-based medicine. 
 
)
 for the prevention of CRC, has specific effects on (sidenote: Fusobacterium nucleatum Increased presence in human colonic adenomas and CRCs, responsible for tissue proliferation in vitro and in animal models. ) , a bacterium associated with this disease.

In vitro and in vivo effect

US researchers have recently shown that aspirin disrupts the growth of the Fn7-1 strain of F. nucleatum, and even kills it, in vitro, in human colonic adenoma tissue cultures. At levels that do not inhibit bacterial growth, aspirin influenced the gene expression of Fn7-1: 55 genes were upregulated and 155 genes downregulated.

To assess aspirin’s role as a modulator of F. nucleatum growth, the researchers also conducted in vivo experiments. In a murine model, Fn7-1 was orally inoculated daily to induce an intestinal tumor, but mice receiving an aspirin-enriched diet saw inhibited tumorigenesis when compared to those on a normal diet. The protective effect of aspirin was also found with other strains of F. nucleatum, including some isolates from human CRC tissues, the latter proving more sensitive than the Fn7-1 strain. Conversely, this protective effect was much milder with other CRC-associated microbes, such as enterotoxigenic Bacteroides fragilis and colibactin-producing Escherichia coli.

Lastly, a (sidenote: Quantitative PCR  Specific PCR (polymerase chain reaction) method used to measure the initial quantity of DNA. 
 
)
 performed on adenoma DNA samples of patients taking aspirin daily showed a 2 to 3-fold lower fusobacterial abundance than in samples taken from control patients. This result suggests that the modulatory effect observed in vitro also occurs in humans.

Antibiotic effect in addition to anti-inflammatory effect

These data confirm the direct antibiotic effect of aspirin on strains of F. nucleatum. Its protective effect against colorectal cancer and adenomas thus exceeds its anti-inflammatory role. Consideration of the potential effects of aspirin on the microbiome holds promise in optimizing risk-benefit assessments for the drug’s use in CRC prevention and management. However, it is unlikely that the anti-inflammatory effects of aspirin alone are enough to stop tumorigenesis in its entirety. Further research is required before its use to improve the prognosis of CRC – the second leading cause of cancer death worldwide – can be considered.

Sources

Brennan CA, Nakatsu G, Gallini Comeau CA, et al. Aspirin Modulation of the Colorectal Cancer-Associated Microbe Fusobacterium nucleatum. mBio. 2021 Apr 6;12(2):e00547-21. 

Tags
Colorectal cancer Antibiotic Aspirin

en_view en_sources

    See also

    Newsletter 4 - article 1 The role of Fusobacterium in colorectal cancer
    Actu PRO : E. coli signe son rôle dans le cancer colorectal Mutational signature of E. coli in colorectal cancer
    Created 16 November 2021
    Updated 18 January 2022

    About this article

    To know more about this topic.

    Main topic

    Cancer

    Medical practice

    Gastroenterology Oncology

    Content type

    News
    Gastroenterology

    Your IBS Diagnosis Check List

    How many patients suffering from gut disorder do you see per week? How many are diagnosed with Irritable Bo...

    Find out more

    Human milk nutrient fortifiers alter the developing gastrointestinal microbiota of very-low-birth-weight infants

    Commented article - Children's section By Pr. Emmanuel M...

    Find out more

    Impact of beer and non alcoholic consumption on the gut microbiota

    By Pr. Bernd SchnablDivision of Gastroenterology, San Diego Digestive Diseases Research Center (SDDRC), UC ...

    Find out more

    Everything you need to know about Irritable Bowel Syndrome (IBS)

    Accrediting training, infographics, expert’s video, thematic folder, news… Biocodex Microbiota Institute pr...

    Find out more

    Gut Microbiota #17

    By Pr. Satu PekkalaAcademy of Finland Research Fellow, Faculty of Sport and Health Sciences, University of ...

    Find out more

    Gut Microbiota # 16

    By Pr. Satu PekkalaAcademy of Finland Research Fellow, Faculty of Sport and Health Sciences, University of ...

    Find out more

    Highlights from the UEGW

    By Dr. Lucas WautersGastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium

    Find out more

    The Gut-Brain axis

    By Pr. Sarkis K. Mazmanian, John W. Bostick, Nadia SuryawinataBiology and Biological Engineering, Californi...

    Find out more

    Continue reading

    News
    14.03.2023

    Positive impact of running on gut microbiota and adolescent depression

    Read the article
    09.03.2023

    Each subtype of Irritable Bowel Syndrome (IBS) has its own dysbiosis

    Read the article
    Parkinson : le microbiote intestinal, chef d’orchestre des mécanismes pathogéniques ?
    27.02.2023

    Does the gut microbiota orchestrate pathogenic mechanisms in Parkinson’s disease?

    Read the article
    Everything you need to know about Microbiota & Immunity
    15.09.2022

    Everything you need to know about Microbiota & Immunity

    Read the article
    The psychobiotic diet: modulating gut microbiota to reduce stress
    13.02.2023

    The psychobiotic diet: modulating gut microbiota to reduce stress

    Read the article
    30.01.2023

    Schizophrenia and aggressive behavior: what involvement of the intestinal microbiota?

    Read the article
    23.01.2023

    Idiopathic urethritis in men: new infectious etiologies?

    Read the article
    13.01.2023

    Insomnia in seniors: a link with the gut microbiota

    Read the article
    What's worth reading about microbiota
    Follow us on Twitter
    Read our thematic folder
    The Janus face of Antibiotics: Life Savers & Microbiota Disrupters
    NL13_cover
    Check out latest newsletter
    IBS, Microbiota & Covid-19
    • Our publications
      • News
      • Microbiota Mag
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographics
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube

    Lay public section

    Find here your dedicated section
    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology
    • English
    • Français
    • Español
    • Russian
    • Portuguese
    • Polish

    Browse the site

    • Our publications
      • News
      • Microbiota Mag
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographics
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

    Lay public section

    Find here your dedicated section

    Redirection

    You are about to be redirected and leave our website

    • Be redirected
    • Stay on the Biocodex Microbiota Institute's website

    Stay with us !

    Join the Microbiota Community of HCPs and researchers and receive “Microbiota Digest” and "Microbiota Mag" to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    Explore

    14.03.2023

    Positive impact of running on gut microbiota and adolescent depression

    Read the article
    09.03.2023

    Each subtype of Irritable Bowel Syndrome (IBS) has its own dysbiosis

    Read the article
    Parkinson : le microbiote intestinal, chef d’orchestre des mécanismes pathogéniques ?
    27.02.2023

    Does the gut microbiota orchestrate pathogenic mechanisms in Parkinson’s disease?

    Read the article

    Stay updated

    Join the Microbiota Community of HCPs and researchers and receive “Microbiota Digest” and "Microbiota Mag" to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    • Our publications
      • News
      • Microbiota Mag
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographics
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology

    Lay public section

    Find here your dedicated section

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

    © 2022 Biocodex. All rights reserved.

    • Cookies Policy
    • Data protection policy
    • GTU
    • Sitemap
    • Cookies settings
    Biocodex logo