The eradication of H. pylori has a lasting effect on the gastric flora


The treatment against Helicobacter pylori infection has a lasting effect on the composition of the intestinal and throat microbiotas. This is what a Chinese team, who studied and described these disruptions in 30 patients, reports. The treatment to eradicate H. pylori includes the administration of several antibiotics, which can have unwanted effects like diarrhea, nausea/vomiting, and Clostridium difficile infection due to disruptions in the intestinal microbiota. Researchers analyzed the intestinal and throat microbiotas in patients aged 18 to 65 who were treated for two weeks with esomeprazole, amoxicillin, clarithromycin, and tinidazole (H. pylori eradication treatment). The 30 patients were divided into 3 groupsarms: one arm where probiotics (including Saccharomyces boulardii) were given during the eradication treatment, one arm where probiotics (including S. boulardii) were given for two weeks post treatment, and lastly one arm that only received the eradication treatment. Treatment effectiveness was the same in all three arms and was associated with significant changes in the microbiota (intestinal and throat). Probiotics supplementation was associated with a reduction in disruptions, particularly in the throat (non-significant difference). The simultaneous administration of probiotics and antibiotics was associated to a reduction in side effects, particularly diarrhea, when compared with antibiotics alone. After two months, the intestinal microbiota had returned at least partially to normal, but the throat still presented significant dysbiosis.


Wang ZJ et al. Effects of anti-Helicobacter pylori concomitant therapy and probiotic supplementation on the throat and gut microbiota in humans. Microb Pathog. 2017;109:156-161.