Skip to main content
About the Institute
  • English
  • Français
  • Español
  • Russian

Breadcrumb

  1. Home
  2. Microbiota 13 - October 2021
  3. DDW congress
  • Our publications
    • News
    • Microbiota Mag
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • Partnerships
    • Press room
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
    • Xpeer App
  • Useful documents
    • Infographics
    • IBS Diagnosis Check List
    About the Institute

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

Lay public section

Find here your dedicated section
Gastroenterology
Gynecology
Pediatrics
Dermatology

Breadcrumb

  1. Home
  2. Microbiota 13 - October 2021
  3. DDW congress
Gastroenterology

DDW congress

Gastroenterology

Congress Review
By Dr. Ericka Montijo Barrios
Pediatric Gastroenterology and Endoscopist, Department of Gastroenterology and Nutrition, Instituto Nacional de Pediatría, Mexican council NASPGHAN, Mexico city, Mexico

Gastroenterology
Gynecology
Pediatrics
Dermatology
  • Our publications
    • News
    • Microbiota Mag
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • Partnerships
    • Press room
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
    • Xpeer App
  • Useful documents
    • Infographics
    • IBS Diagnosis Check List
    About the Institute

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

Lay public section

Find here your dedicated section

Sources

This article is based on scientific information

Sharing is caring

Your colleagues might be interested in this topic. Why not share it?

  • Facebook
  • Twitter
  • LinkedIn
  • Mail

Sections

NL13_DDW congress

About this article

Created 24 October 2021
Updated 06 January 2022

The Digestive disease week 2021 moves online this year and was held from May 21-23, 2021. It is the first meeting for physicians and researchers in the fields of gastroenterology, hepatology, endoscopy and surgery. DDW features more than 300 original lecture sessions and interesting posters [1-7].

Microbiota and Functional Gastrointestinal Disease

The gut microbiome can be viewed as a dynamic organ capable of mediating a wide variety of biochemical transformations that directly impact host physiology and disease. A disruption in this equilibrium can lead to alteration of host physiology resulting in disease such as functional gastrointestinal disorders (FGIDs).

Modifying factors in adult microbiota includes psychological stress, infectious gastroenteritis, physical activity, tobacco use, alcohol consumption, antibiotic exposure and the diet (including low fermentable oligosaccharides, disaccharides, monosaccharides and polyols diet). It is well known that antibiotic induced dysbiosis could lead to hyperalgesia. Jones et al. presented that more FGID patients are over prescribed antibiotics relative to non-FGID patients and more than 25% recorded antibiotic within prior their first FGDI diagnosis [4].

Microbial mediators of gastrointestinal motility are: short chain fatty acids (SCFAs) that increase serotonin biosynthesis, increase colonic hypersensitivity and decrease visceral sensitivity; bile acids, promotes propagating and non-propagating colonic contractions, stimulate secretion; methane augments small bowel contractility and slows intestinal transit and hydrogen gas shortens transit.

Gastrointestinal disorders with pain as the key symptoms

Pain in some FGIDs has been attributed to visceral hypersensitivity to mechanical and chemical stimuli. Most of the evidence for a role of the gut microbiome in regulating GI sensation comes from gnotobiotic studies showing that the visceral hypersensitivity phenotype can be transferred after transplantation of gut microbiota from patients with FGIDs into germ free mice.

FGIDs, are the most frequent diseases associated with visceral pain. Inflammatory pain results from the altered activity of ion channels within peripheral nociceptive sensory fibers by inflammatory mediators, which leads to increased excitability and pain. The list of pro-inflammatory mediators includes TNF-α, IL-1β, CCL2, chemokine, ligand 1 and prostaglandin E2. It has been shown that inflammatory pain induced by these mediators is lower in germ-free mice and showed increased levels of the anti- inflammatory cytokine IL-10.

Microbial dysbiosis can trigger a localized immune response associated with the production of dietary antigenic specific IgE antibodies, leading to mast cell mediated hyperalgesia. Bacterial histamine can induce hyperalgesia trough H4R mediated pathways. It is shown that injection of food antigens (gluten, wheat, soy and milk) into the rectosigmoid mucosa of patients with irritable bowel syndrome induced local oedema and mast cell activation.

Conclusion

Antibiotics frequently precede first diagnosis of functional gastrointestinal disorders. There is emerging evidence that small intestinal dysbiosis plays an important role in the pathophysiology of FGIDs. Accumulating data suggest that gut microbiota may play a role in the abdominal pain modulation. Microbial dysbiosis can trigger hyperalgesia inducing low grade inflammation.

Sources

1 Shin A, Preidis GA, Shulman R, Kashyap, P. The gut microbiome in adult and pediatric functional gastrointestinal disorders. Clin Gastroenterol Hepatol 2019; 17: 256-74.

2 Santoni M, Miccini F, Battelli N. Gut microbiota, immunity and pain. Immunol Lett 2021; 229: 44-7.

3 Gurusamy S, Shah A, Talley N, et al. Small Intestinal Bacterial Overgrowth in functional Dyspepsia: A systematic review and meta-analysis. DDW ePoster Library 2021; 320192; Sa389.

4 Jones M, Walker M, Holtmann G, et al. Antibiotics frequently precede first diagnosis of functional gastrointestinal disorders. DDW ePoster Library 2021; 319221; Fr071.

5 Bercik P. Host-microbe interactions as a means of understanding visceral hypersensivity. Conference. DDW2021 virtual. May 21-23.

6 Kashyap P. Small Intestinal Bacterial Overgrowth Hype: Role of dietary fiber. Conference. DDW2021 virtual. May 21-23.

7 Microbes and functional GI disease: The science behind the hype. Lecture. DDW2021 virtual. May 21-23.

Tags
Digestive disorder

en_view en_sources

    Focus
    Microbiota 13 - October 2021
    • Overview
      • Microbiota gut-brain axis in Irritable Bowel Syndrome
      • What is the impact of Covid-19 on the human microbiome?
    • Commented article
      • Faecal microbiota transplantation overcomes resistance to anti-PD-1 treatment in patients with melanoma
      • High-fibre diet mitigates maternal obesity-induced cognitive and social dysfunction in the offspring via gut-brain axis
    • Congress Review
      • DDW congress
      • Microbiota highlights from the 6th WCPGHAN 2021 Summit
    • Press Review
      • Gut microbiota #13
      • Vaginal microbiota #13
      • Skin microbiota #13
    Created 24 October 2021
    Updated 06 January 2022

    About this article

    To know more about this topic.

    Main topic

    Gastroenterology

    Content type

    Congress review
    High-fibre diet mitigates maternal obesity-induced cognitive and social dysfunction in the offspring via gut-brain axis
    Microbiota highlights from the 6th WCPGHAN 2021 Summit
    Focus

    Microbiota 13 - October 2021

    Overview

    Microbiota gut-brain axis in Irritable Bowel Syndrome What is the impact of Covid-19 on the human microbiome?

    Commented article

    Faecal microbiota transplantation overcomes resistance to anti-PD-1 treatment in patients with melanoma High-fibre diet mitigates maternal obesity-induced cognitive and social dysfunction in the offspring via gut-brain axis

    Congress Review

    DDW congress Microbiota highlights from the 6th WCPGHAN 2021 Summit

    Press Review

    Gut microbiota #13 Vaginal microbiota #13 Skin microbiota #13
    Gastroenterology
    Everything you need to know about the microbiota gut-brain axis
    22.05.2023

    Everything you need to know about the microbiota gut-brain axis

    Read the article
    SII, microbiote intestinal et dépression : un triptyque pour mieux comprendre la maladie
    27.07.2022

    IBS, gut microbiota and depression: a trio shedding light on the disease

    Read the article
    Actu PRO : Cancer du poumon : le microbiote intestinal signerait un stade précoce
    02.07.2020

    Gut microbiota could be an indicator of early-stage lung cancer

    Read the article
    Obesity: Is a bacterial fatty acid involved?
    15.05.2023

    Obesity: Is a bacterial fatty acid involved?

    Read the article
    Photo: Endométriose : une clé de sa progression au sein du microbiote intestinal
    09.05.2023

    Endometriosis: A key to its progression in the gut microbiota?

    Read the article
    16.11.2022

    Alcohol use disorders: in microbiota veritas?

    Read the article
    Photo: Atténuer la dénutrition avec des biotiques ?
    26.04.2023

    Mitigating malnutrition with biotics?

    Read the article
    25.04.2023

    F. prausnitzii : a biomarker of chronic fatigue syndrome

    Read the article
    What's worth reading about microbiota
    Follow us on Twitter
    Read our thematic folder
    The Janus face of Antibiotics: Life Savers & Microbiota Disrupters
    Microbiota 17 EN
    Check out our latest magazine
    The first 1000 days of life
    • Our publications
      • News
      • Microbiota Mag
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographics
      • IBS Diagnosis Check List
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube

    Lay public section

    Find here your dedicated section
    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology
    • English
    • Français
    • Español
    • Russian

    Browse the site

    • Our publications
      • News
      • Microbiota Mag
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographics
      • IBS Diagnosis Check List
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

    Lay public section

    Find here your dedicated section

    Redirection

    You are about to be redirected and leave our website

    • Be redirected
    • Stay on the Biocodex Microbiota Institute's website

    Stay with us !

    Join the Microbiota Community of HCPs and researchers and receive “Microbiota Digest” and "Microbiota Mag" to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    Explore

    Everything you need to know about the microbiota gut-brain axis
    22.05.2023

    Everything you need to know about the microbiota gut-brain axis

    Read the article
    Obesity: Is a bacterial fatty acid involved?
    15.05.2023

    Obesity: Is a bacterial fatty acid involved?

    Read the article
    Photo: Endométriose : une clé de sa progression au sein du microbiote intestinal
    09.05.2023

    Endometriosis: A key to its progression in the gut microbiota?

    Read the article

    Stay updated

    Join the Microbiota Community of HCPs and researchers and receive “Microbiota Digest” and "Microbiota Mag" to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    • Our publications
      • News
      • Microbiota Mag
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographics
      • IBS Diagnosis Check List
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology

    Lay public section

    Find here your dedicated section

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

    © 2022 Biocodex. All rights reserved.

    • Cookies Policy
    • Data protection policy
    • GTU
    • Sitemap
    • Cookies settings
    Biocodex logo