Skip to main content
About the Institute
  • English
  • Français
  • Español
  • Portuguese
  • Polish

Breadcrumb

  1. Home
  2. Gastroenterology
  3. Does the gut microbiota influence vaccine efficacy?
  • Our publications
    • News
    • Microbiota Mag
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • Partnerships
    • Press room
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
    • Xpeer App
  • Useful documents
    • Infographics
    About the Institute

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

Lay public section

Find here your dedicated section
Gastroenterology
Gynecology
Pediatrics
Dermatology

Breadcrumb

  1. Home
  2. Gastroenterology
  3. Does the gut microbiota influence vaccine efficacy?
Gastroenterology

Does the gut microbiota influence vaccine efficacy?

Immunity
Pediatrics

Some children treated with vaccines fail to develop protective immunity, especially in low- and middle-income countries. The gut microbiota is intimately linked to immune function and may be one of the factors responsible for this variability in vaccine response.

Gastroenterology
Gynecology
Pediatrics
Dermatology
  • Our publications
    • News
    • Microbiota Mag
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • Partnerships
    • Press room
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
    • Xpeer App
  • Useful documents
    • Infographics
    About the Institute

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

Lay public section

Find here your dedicated section

Sources

This article is based on scientific information

Sharing is caring

Your colleagues might be interested in this topic. Why not share it?

  • Facebook
  • Twitter
  • Mail

About this article

Created 16 December 2022
Updated 03 January 2023

Vaccines are one of the greatest successes of public health, saving millions of lives worldwide, especially among young children (0-5 years), who are more vulnerable to infectious diseases. However, their efficacy varies from one population to another, with higher rates of protective immunity in European countries than in low- and middle-income countries (LMIC). Since the development of the gut microbiota in early life is intimately linked to the maturation of the immune system, and the microbiota of children in LMIC differ significantly from those of European children, researchers reviewed the evidence pointing to the gut microbiota’s role in disparities in vaccine response.

Immunomodulatory properties

A study on vaccines against tuberculosis, tetanus, hepatitis B, and poliomyelitis in Bangladeshi infants found that the presence of certain taxa is correlated with the rate of vaccine response, positively in the case of Actinobacteria, but negatively for Enterobacteriaceae. In addition, interventions to modify the microbiota (prebiotics, probiotics, antibiotics) provide further evidence of its involvement in vaccine response. A 2018 systematic review summarized the results of 26 studies in humans that used probiotics to enhance the efficacy of various vaccines. The review found positive outcomes in half the studies. Conversely, studies investigating the effects of antibiotics found either no improvement or a reduced immune response, which was attributed to disruption of the microbiota.

Two bacterial genera especially involved 

Two bacterial genera seem particularly capable of modulating responses to vaccines. Bifidobacterium and Bacteroides are essential for the development of a healthy microbiota in young children. However, young children can face significant microbiota disruptions (cesarean section, etc.). The effects of the microbiota on vaccine responses appear to be mediated by certain metabolites and/or cellular components, such as short-chain fatty acids, exopolysaccharides, or extracellular vesicles.

Towards a new generation of vaccine strategies

Although the relevant strains and products need to be better characterized, the intricate relationship between the microbiota and vaccine efficacy opens up rich clinical perspectives. This includes new vaccine stimulation therapies able to improve protection for children from LMIC without the use of adjuvants, which are often thought to have adverse side effects.

Sources

Jordan A, Carding SR, Hall LJ. The early-life gut microbiome and vaccine efficacy. Lancet Microbe. 2022 Oct;3(10):e787-e794. doi: 10.1016/S2666-5247(22)00185-9.

Tags
Vaccination Immunity Vaccine Antibiotic Prebiotic Probiotics

en_view en_sources

    See also

    Actu PRO : Vaccination post-antibiothérapie : effet sur l’immunité, rôle du microbiote Targeting the gut microbiota to optimize vaccine efficacy?
    Actu PRO : Vaccination post-antibiothérapie : effet sur l’immunité, rôle du microbiote Vaccination after antibiotic therapy: effect on immunity and role of the microbiota
    Created 16 December 2022
    Updated 03 January 2023

    About this article

    To know more about this topic.

    Main topic

    Immunity

    Medical practice

    Pediatrics

    Content type

    News
    Gastroenterology

    Your IBS Diagnosis Check List

    How many patients suffering from gut disorder do you see per week? How many are diagnosed with Irritable Bo...

    Find out more

    Everything you need to know about Irritable Bowel Syndrome (IBS)

    Accrediting training, infographics, expert’s video, thematic folder, news… Biocodex Microbiota Institute pr...

    Find out more

    Gut Microbiota #17

    By Pr. Satu PekkalaAcademy of Finland Research Fellow, Faculty of Sport and Health Sciences, University of ...

    Find out more

    Impact of beer and non alcoholic comsumption on the gut microbiota

    By Pr. Bernd SchnablDivision of Gastroenterology, San Diego Digestive Diseases Research Center (SDDRC), UC ...

    Find out more

    Gut Microbiota # 16

    By Pr. Satu PekkalaAcademy of Finland Research Fellow, Faculty of Sport and Health Sciences, University of ...

    Find out more

    Highlights from the UEGW

    By Dr. Lucas WautersGastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium

    Find out more

    The Gut-Brain axis

    By Pr. Sarkis K. Mazmanian, John W. Bostick, Nadia SuryawinataBiology and Biological Engineering, Californi...

    Find out more

    Human milk nutrient fortifiers alter the developing gastrointestinal microbiota of very-low-birth-weight infants

    Commented article - Children's section By Pr. Emmanuel M...

    Find out more

    Continue reading

    News
    23.01.2023

    Idiopathic urethritis in men: new infectious etiologies?

    Read the article
    13.01.2023

    Insomnia in seniors: a link with the gut microbiota

    Read the article
    03.01.2023

    Almonds: limited effects on the gut microbiota

    Read the article
    14.12.2022

    Microplastics in takeaway food put gut and oral flora at risk

    Read the article
    05.12.2022

    Can gut bacteria and metabolites help the earlier prediction of necrotizing enterocolitis in newborns?

    Read the article
    Photo: WAAW 2022 (HCPs)
    25.10.2022

    Microbiota at the forefront of antibiotic resistance

    Read the article
    25.10.2022

    Antibiotics: Dr Jekyll and Mr Hyde

    Read the article
    Everything you need to know about Microbiota & Dysbiosis
    27.07.2022

    Everything you need to know about Dysbiosis

    Read the article
    What's worth reading about microbiota
    Follow us on Twitter
    Read our thematic folder
    The Janus face of Antibiotics: Life Savers & Microbiota Disrupters
    NL13_cover
    Check out latest newsletter
    IBS, Microbiota & Covid-19
    • Our publications
      • News
      • Microbiota Mag
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographics
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube

    Lay public section

    Find here your dedicated section
    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology
    • English
    • Français
    • Español
    • Portuguese
    • Polish

    Browse the site

    • Our publications
      • News
      • Microbiota Mag
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographics
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

    Lay public section

    Find here your dedicated section

    Redirection

    You are about to be redirected and leave our website

    • Be redirected
    • Stay on the Biocodex Microbiota Institute's website

    Stay with us !

    Join the Microbiota Community of HCPs and researchers and receive “Microbiota Digest” and "Microbiota Mag" to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    Explore

    23.01.2023

    Idiopathic urethritis in men: new infectious etiologies?

    Read the article

    Impact of beer and non alcoholic comsumption on the gut microbiota

    By Pr. Bernd SchnablDivision of Gastroenterology, San Diego Digestive Diseases Research Center (SDDRC), UC ...

    Find out more

    Skin Microbiota #17

    By Pr. Satu PekkalaAcademy of Finland Research Fellow, Faculty of Sport and Health Sciences, University of ...

    Find out more

    Stay updated

    Join the Microbiota Community of HCPs and researchers and receive “Microbiota Digest” and "Microbiota Mag" to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    • Our publications
      • News
      • Microbiota Mag
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographics
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology

    Lay public section

    Find here your dedicated section

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

    © 2022 Biocodex. All rights reserved.

    • Cookies Policy
    • Data protection policy
    • GTU
    • Sitemap
    • Cookies settings
    Biocodex logo