Public Area
Access Pro

Mood disorders

Depression and bipolar disorder indicate a mood disorder. Beyond classic psychiatric treatments, research is in progress to evaluate the impact of intestinal microbiota on these disorders.

Mood disorders are common: 300 million people in the world suffer from depression and 60 million have bipolar disorder.  These disorders cause mental distress that can often be severe, which can lead to suicide. They are the #1 cause of professional and social disability in the world.

Inappropriate stress response

Each individual has their own vulnerability to depression or bipolar disorder, which is in part genetic.  As a result, during unpleasant life events, some people experience an excessive response, with overly elevated secretion of the stress hormones cortisol and adrenaline. This situation can lead to nervous exhaustion and favor the onset of a depressive state. Recent research has also documented the role of intestinal flora (microbiota) in these inappropriate stress responses. Indeed in animals, microbiota participates in the regulation of emotions through communication between the intestine and the brain. In the case of dysbiosis (disruptions in the composition of the microbiota), this regulation is less effective and favors the onset of mood disorders.

A new avenue for treatment

Beyond classic treatments (antidepressants, mood regulators, psychotherapy, etc.), a new avenue is opening: rebalancing the microbiota to influence mood. A recent study also showed that taking probiotics daily, a combination of lactobacilli and bifidobacteria, improved mood and reduced the level of anxiety in healthy subjects.

Diseases related to the nervous system

  • Alzheimer's disease

    Alzheimer's disease, whose factors are still poorly understood, still has no effective treatment. However, a hypothesis around the role of ...
  • Parkinson's disease

    Parkinson’s disease is the second most common neurodegenerative disease in France. It progressively destroys the dopamine neurons in the bra...
  • Autism-spectrum disorders

    Autism-spectrum disorders (ASDs) refer to the collection of neurobiological diseases that affect social interactions. They may have a gastro...
  • Anxiety disorders

    Certain anxiety disorders, which a great number of people suffer from, may be linked to activity in the gastrointestinal microbiota through ...
  • Schizophrenia

    Chronic inflammation in the brain is suspected in schizophrenia. Disruptions in the gastrointestinal microbiota and the immune system may a...