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  2. Mental health and gut microbiota, towards new therapeutic avenues?
  3. Bipolar disorders
The power of your gut

Bipolar disorders

Gut-brain axis
The gut microbiota Mood disorders

They are characterized by swings between phases of depression and phases of overexcitement called “manic episodes”. The composition of patients’ gut microbiota is different from that of healthy individuals and its diversity is particularly reduced in affected women.

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About this article

Created 17 September 2019
Updated 30 December 2021

Bipolar patients (as well as schizophrenics) have increased levels of antibodies against fungi (Saccharomyces cerevisiae and Candida albicans) that are naturally present in the gastrointestinal tract. The presence of a specific protein in the blood indicates that bacteria usually located in the intestines were able to migrate. Moreover, concentrations of anti- Saccharomyces cerevisiae antibodies are higher in treatment-naive patients than in those who are treated with antipsychotics. These observations strengthen the hypothesis of a link between disease and inflammation26.

Is nutrition education an avenue to pursue?

Yes, without a doubt, according to some psychiatrists who rely on diet to reduce inflammation and restore gut microbiota balance27. Actually, a link between Western diet (high intake of carbohydrates and fat) and a disruption of neural and inflammation activity has been demonstrated. On the contrary, Mediterranean diet is the example to follow: it could have a protective effect against bipolar disorders as well as depression. The same could be said of omega-3 intake.

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Bipolar disorders infography
Sources

26 Nguyen TT, Kosciolek T, Eyler LT, et al. Overview and systematic review of studies of microbiome in schizophrenia and bipolar disorder. Journal of Psychiatric Research, 2018

27 Beyer JL, Payne ME. Nutrition and Bipolar Depression. Psychiatric Clinics of North America, 2016

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    Created 17 September 2019
    Updated 30 December 2021

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