Skip to main content
  • English
  • Français
  • Español
  • Russian

Breadcrumb

  1. Home
  2. Microbiota and child health
  3. Infectious diarrhea and intestinal microbiota
  • Our publications
    • News
    • Microbiota Mag
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • Partnerships
    • Press room
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
    • Xpeer App
  • Useful documents
    • Infographic
    About the Institute

    Join the microbiota community

    • Facebook
    • Twitter
    • YouTube

Lay public section

Find here your dedicated section
Gastroenterology
Gynecology
Pediatrics
Dermatology

Breadcrumb

  1. Home
  2. Microbiota and child health
  3. Infectious diarrhea and intestinal microbiota
Pediatrics

Infectious diarrhea and intestinal microbiota

Diarrhea
Pediatrics Gastroenterology

A close relationship has been established between childhood gastrointestinal disorders and intestinal microbiota. The composition of the intestinal microbiota impacts the risk of developing certain disorders, and conversely, a dysbiosis caused by a gastrointestinal disorder can play a role in promoting, worsening or increasing the recurrence of the underlying disorder. Research is focused on gaining a better knowledge of etiopathogenesis in order to develop new therapeutic and prophylactic solutions.

Gastroenterology
Gynecology
Pediatrics
Dermatology
  • Our publications
    • News
    • Microbiota Mag
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • Partnerships
    • Press room
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
    • Xpeer App
  • Useful documents
    • Infographic
    About the Institute

    Join the microbiota community

    • Facebook
    • Twitter
    • YouTube

Lay public section

Find here your dedicated section

Sources

This article is based on scientific information

Sharing is caring

Your colleagues might be interested in this topic. Why not share it?

  • Facebook
  • Twitter
  • Mail

Sections

About this article

Created 21 October 2019
Updated 12 October 2021

The fight against infectious diarrhea is a priority of healthcare systems in developing countries, since this pathology is the second cause of child mortality in these regions. Describing the intestinal microbiota and its dysbioses are part of this fight and could help offer personalized treatments.

RISKS ASSOCIATED TO DIARRHEA

Recurrent or prolonged diarrhea episodes increase the risk of malnutrition and stunted growth. They are also associated to numerous comorbidities: cognitive disorders, cardiovascular diseases, glucose intolerance, etc. Despite a regular decrease, near 525,000 children under 5 years of age die every year in the world. Understanding the etiology of diarrhea is a health priority, but the wide variety of types and potential causes requires further investigation, especially in terms of correlation with the intestinal microbiota. A recent study focused on Vietnamese population was added to the existing body of scientific literature on infectious diarrhea. It characterized the bacterial communities of 145 children with diarrhea and 54 controls.17

Image
Infectious-diarrhea-infographie-1

ETIOLOGIC AGENTS WERE IDENTIFIED

Bacterial analysis of fecal samples revealed four major types of bacterial predominance in children with diarrhea: Bifidobacterium, Bacteroides, Streptococcus and Escherichia. The first two categories, usually asymptomatic, are close to the composition of the microbiota of control children. Predominance of Streptococcus and Escherichia in the microbiota of children who had the most severe symptoms, confirmed previous studies that associated these microorganisms with a higher risk of gastrointestinal disorders. Bacterial depletion was also observed in all categories. Nineteen taxa are concerned (mainly belonging to the Clostridiales and Erysipelotrichales orders) and especially Blautia hansenji which is known for its ability to produce SCFA19, essential to homeostasis.

INDIVIDUAL VULNERABILITIES

Age, nutritional status, intake of breast milk and etiology seem to contribute to the composition of bacterial communities during the early phase of diarrhea episodes. Streptococcus are more largely associated to young children (under 2) and bacterial infections, while Escherichia are found in older children and/or children with poor nutritional status. This extensive characterization is part of the analysis of the complex influences of infectious diarrheas on the intestinal microbiota and guides research towards new therapeutic approaches.

KEY FIGURES FOR DIARRHEA

Definition: passage of three or more loose or watery stools per day

  • Acute watery diarrhea lasting several hours or days
  • Watery and bloody diarrhea, or dysentery
  • Persistent diarrhea (14 or more consecutive days)

 

There are about 1.7 billion cases of diarrhea annually in children in the world.

2nd cause of death and major cause of malnutrition in children under.

525,000 deaths per year of children aged 5 or less in the world.

[Source] : WHO: Fact sheets on diarrhoeal-disease, mai 2017
Sources

17 The HC, Florez de Sessions P, Jie S, et al. Assessing gut microbiota perturbations during the early phase of infectious diarrhea in Vietnamese children. Gut Microbes. 2018;9(1):38-54.

18 Pop M, Walker AW, Paulson J, et al. Diarrhea in young children from low-income countries leads to large-scale alterations in intestinal microbiota composition. Genome Biol. 2014;15(6):R76. 

19 Short-chain fatty acids. They are products of carbohydrate fermentation (organic anions and saturated fatty acids) carried out by anaerobic bacteria in the colon

 

Old sources

 

 

Tags
Diarrhea Gut health Children & baby health

en_view en_sources

    Focus
    Microbiota and child health
    • Impact of antibiotics
      • Antibiotics, child microbiota and long-term health effects
      • Focus on the risks of excess weight and obesity
      • Zoom on the risks of IBD
    • Behavioral disorders
      • The role of oral and intestinal microbiota and mycobiome in autism
      • Gut-brain axis and ADHD in adolescents
    • Respiratory diseases
      • Respiratory microbiota and pulmonary infections associated with cystic fibrosis
      • Nasal microbiota: a reliable marker of bronchiolitis severity
    • Gastrointestinal disorders
      • Infectious diarrhea and intestinal microbiota
      • Is intestinal dysbiosis the cause of persistent diarrhea?
    • Expert opinion
      • Pr. Olivier Goulet : Gastrointestinal disorders in children, the need to act
    Created 21 October 2019
    Updated 12 October 2021

    About this article

    To know more about this topic.

    Main topic

    Diarrhea

    Medical practice

    Pediatrics Gastroenterology

    Content type

    Dossier detail
    Nasal microbiota: a reliable marker of bronchiolitis severity
    Is intestinal dysbiosis the cause of persistent diarrhea?
    Focus

    Microbiota and child health

    Impact of antibiotics

    Antibiotics, child microbiota and long-term health effects Focus on the risks of excess weight and obesity Zoom on the risks of IBD

    Behavioral disorders

    The role of oral and intestinal microbiota and mycobiome in autism Gut-brain axis and ADHD in adolescents

    Respiratory diseases

    Respiratory microbiota and pulmonary infections associated with cystic fibrosis Nasal microbiota: a reliable marker of bronchiolitis severity

    Gastrointestinal disorders

    Infectious diarrhea and intestinal microbiota Is intestinal dysbiosis the cause of persistent diarrhea?

    Expert opinion

    Pr. Olivier Goulet : Gastrointestinal disorders in children, the need to act

    Continue reading

    News
    26.04.2022

    Severe obesity: the vicious circle of biotin metabolism

    Read the article
    22.04.2022

    SCFAs: new intestinal markers of Parkinson’s disease?

    Read the article

    The blue poop challenge: a reliable method to evaluate gut transit?

    By Pr. Gianluca Ianiro Gastroenterology Department, Fondazione Policlinico Universitario Agostino Gemelli- ...

    Find out more

    New perspectives in autism: the role of microbiota in social communication

    Overview By Dr. Vincent Trebossen Child and Adolescent P...

    Find out more

    Infographics to share with your patients!

    Download original graphic material to explain to your patients the role of the microbiota in their daily he...

    Find out more
    15.04.2022

    Multiple sclerosis and microbiota: does meat consumption play a role?

    Read the article

    Association between fungal dysbiosis and environment

    The fungal portion of the gut microbiota (or mycobiota) has been much less studied than the bacterial porti...

    Find out more
    08.04.2022

    Inflammatory Bowel Disease (IBD): do microplastics condition severity?

    Read the article
    What's worth reading about microbiota
    Follow us on Twitter
    Read our thematic folder
    The Janus face of Antibiotics: Life Savers & Microbiota Disrupters
    NL13_cover
    Check out latest newsletter
    IBS, Microbiota & Covid-19
    • Our publications
      • News
      • Microbiota Mag
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographic
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • YouTube

    Lay public section

    Find here your dedicated section
    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology
    • English
    • Français
    • Español
    • Russian

    Browse the site

    • Our publications
      • News
      • Microbiota Mag
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographic
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • YouTube

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology

    Join the microbiota community

    • Facebook
    • Twitter
    • YouTube

    Lay public section

    Find here your dedicated section

    en_redirection

    en_you_are_about_to_leave

    • en_be_redirected
    • en_stay_on_biocodex

    Stay with us !

    Join the Microbiota Community of HCPs and researchers and receive once a month the “Microbiota Digest” to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    Explore

    04.05.2022

    Miscarriage: Is vaginal dysbiosis a suspect?

    Read the article
    26.04.2022

    Severe obesity: the vicious circle of biotin metabolism

    Read the article
    22.04.2022

    SCFAs: new intestinal markers of Parkinson’s disease?

    Read the article

    Stay updated

    Join the Microbiota Community of HCPs and researchers and receive once a month the “Microbiota Digest” to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    • Our publications
      • News
      • Microbiota Mag
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographic
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • YouTube

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology

    Lay public section

    Find here your dedicated section

    Join the microbiota community

    • Facebook
    • Twitter
    • YouTube

    © 2022 Biocodex. All rights reserved.

    • Cookies Policy
    • Data protection policy
    • GTU
    • Sitemap
    • Cookies settings
    Biocodex logo