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The power of your gut

Antibiotics and neurodevelopmental disorders: does the microbiota play a role?

Antibiotics
The gut microbiota Autism-spectrum disorders

Antibiotics are often essential to treating certain infections from an early age. But by creating microbiota imbalances, might they influence the development of a child’s nervous system and contribute to disorders such as autism? A recent experimental study1 on mice provides the first – tentative – elements of an answer.

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This article is based on scientific information

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About this article

Created 22 November 2021
Updated 03 November 2022

Neurodevelopmental disorders (NDD) such as autism or attention deficit hyperactivity disorder (ADHD) may be caused by disturbances in the first months of life when the central nervous system (brain, nerves, spinal cord, etc.) is under development. Their origin is still poorly understood, but many genetic and environmental factors are thought to be involved. Might antibiotics be among them? 

28.10.2021 6 things you should know about antibiotics Read more

Antibiotics

They have saved millions of lives but their excessive and inappropriate use has now raised serious concerns for health, notably with antibiotic resistance and microbiota dysbiosis. ach year, the WHO organizes the World Antimicrobial Awareness Week (WAAW) to increase awareness of antimicrobial resistance. Let’s take a look at this dedicated page:

Antibiotics: what impact on the microbiota and on our health?

Learn more

Gut-brain axis suspected

According to a team of scientists in the US, a number of indications suggest this may be the case. The incidence of NDD has been rising sharply over the last few decades, with exposure to antibiotics only widespread since 1945. In the US, an average child receives nearly 3 courses of antibiotics before the age of 2, a critical period for neurodevelopment.

Image
Infog: Perinatal Period - EN

We also know that the gut acts as our “second brain” thanks to a biochemical “axis” of communication between the two organs. Recent research suggests that antibiotics taken during childhood disrupt the developing gut microbiota.2 At the same time, a link has been found between dysbiosis and various diseases, including neurological and psychiatric disorders.2

03.11.2021 Have you heard of "dysbiosis"? Read more

The researchers therefore administered very low doses of penicillin to newborn mice for three weeks. By comparing their microbiota to that of untreated mice, they found an alteration in their gut flora, notably a decrease in “good” bacteria, lactobacilli. Furthermore, they identified different activity between the two groups in 74 frontal cortex genes and 23 amygdala genes. These two parts of the brain are highly involved in emotional and cognitive functions and are also vulnerable to early disturbances. The researchers were also able to discover a link between certain microorganisms in the microbiota and genetic expressions in these brain areas.

Image
Infog: Dysbiosis and pathologies - EN

Role and impact of antibiotics on childhood neurodevelopment not yet explored 

Therefore, in mice, antibiotics taken very early in life may, even at low doses, affect the activity of certain genes in brain areas (frontal cortex and amygdala) that are involved in NDD in humans. But the scientists remain cautious: they have not determined with certainty whether these changes in gene expression are directly caused by the antibiotics or by their effects on the microbiota. It also remains to be shown that these changes are significant for neurodevelopment. Moreover, results obtained in mice are not necessarily translatable to humans. They rather open new paths of research.

What is the World Antimicrobial Awareness Week?

Each year, since 2015, the WHO organizes the World Antimicrobial Awareness Week (WAAW), which aims to increase awareness of global antimicrobial resistance. 

Antimicrobial resistance occurs when bacteria, viruses, parasites and fungi change over time and no longer respond to medicines. As a result of drug resistance, antibiotics and other antimicrobial medicines become ineffective and infections become increasingly difficult or impossible to treat, increasing the risk of disease spread, severe illness and death.
Held on 18-24 November, this campaign encourages the general public, healthcare professionals and decision-makers to use antibiotics, antivirals, antifungals and antiparasitics carefully, to prevent the further emergence of antimicrobial resistance.

Sources

1 Volkova A, Ruggles K, Schulfer A, et al.“Effects of early-life penicillin exposure on the gut microbiome and frontal cortex and amygdala gene expression.” iScience vol. 24,7 102797.

2 Skonieczna-Żydecka K, Marlicz W, Misera A, et al. “Microbiome-The Missing Link in the Gut-Brain Axis: Focus on Its Role in Gastrointestinal and Mental Health.” Journal of clinical medicine vol. 7,12 521. 

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Antibiotics Autism Child Gut-brain axis WAAW World Antimicrobial Awareness Week Dysbiosis ASDs

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    See also

    Microbiota and Autism spectrum disorders
    Actu GP : Autisme : quand l’intestin fait la pluie et le beau temps Autism: when the gut calls the shots
    Created 22 November 2021
    Updated 03 November 2022

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