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Dermatology

Modulating the skin microbiota via topical applications

Skin health
Dermatology

Preventing and treating dysbiosis without eliminating pathogens: novel therapeutic strategies aim to rebalance the skin microbiota directly via topical applications, or indirectly via oral solutions that modulate the gut ecosystem.

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Staphylococcus epidermidis

About this article

Created 22 April 2021
Updated 27 October 2021

The first clinical trials seem to support the use of topical applications to rebalance the skin microbiota. However, further trials are needed to confirm these results.

In general, there have been few clinical trials evaluating the topical application of probiotics in skin diseases.12 For acne, creams containing S. epidermidis or bacteriophages of C. acnes that preferentially target pathogenic strains have shown positive results.12 The application of R. mucosa in patients with atopic dermatitis may reduce lesion severity, the need to use topical steroids and the presence of S. aureus.28,29 The limited availability of microbial candidates on the skin has forced researchers to also use other sources of microorganisms. Derived from thermal spring water, Vitreoscilla filiformis may be beneficial in seborrheic dermatitis: one study reported a reduction in erythema, desquamation and pruritus by soothing the inflammation.12 

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In acne, Nitrosomonas eutropha decreases lesion severity12, while the topical use of bacterial products (E. faecalis enterocins) reduces lesions by 60% compared to controls.12 An alternative strategy corrects the dysbiosis by using sucrose to promote the growth of S. epidermidis over C. acnes.9 Scientific data are scant for skin cancer and non-existent for rosacea. In murine models of UV-related cancers, a molecule produced by S. epidermidis was shown to inhibit tumor proliferation.12,16

Sources

12 Yu Y, Dunaway S, Champer J, et al. Changing our microbiome: probiotics in dermatology. Br J Dermatol. 2020;182(1):39-46.

16 Squarzanti DF, Zavattaro E, Pizzimenti S et al. Non-Melanoma Skin Cancer: news from microbiota research. Crit Rev Microbiol. 2020;46(4):433-449.

28 Myles IA, Earland NJ, Anderson ED, et al. First-in-human topical microbiome transplantation with Roseomonas mucosa for atopic dermatitis. JCI Insight. 2018;3(9):e120608

29 Drago L, Toscano M, De Vecchi E, et al. Changing of fecal flora and clinical effect of L. salivarius LS01 in adults with atopic dermatitis. J Clin Gastroenterol. 2012;46.Suppl:S56-S63.

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Tags
Psoriasis Acne Test Skin health Rosacea Gut-skin axis Atopic Dermatitis

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    Focus
    Skin under triple influences : gut, brain, skin microbiota
    • The skin microbiota
      • A unique set of skin microbiota for each individual
      • Factors affecting the skin microbiota
      • Functions of the microbiota and its interactions with the host
    • Skin diseases associated with a dysbiosis
      • Skin diseases associated with a dysbiosis
      • Non-pathological skin conditions associated with a dysbiosis
    • The gut-skin axis
      • Psoriasis, atopic dermatitis, rosacea: gut-skin axis involved
      • A gut-brain-skin axis?
    • Modulating the skin microbiota
      • Modulating the skin microbiota via topical applications
      • Modulating the skin microbiota with oral solutions
    • Expert opinion
      • Dr. Markus Eger : Probiotics, a complementary therapeutic option
    Created 22 April 2021
    Updated 27 October 2021

    About this article

    To know more about this topic.

    Main topic

    Skin health

    Medical practice

    Dermatology

    Content type

    Dossier detail
    A gut-brain-skin axis?
    Modulating the skin microbiota with oral solutions
    Focus

    Skin under triple influences : gut, brain, skin microbiota

    The skin microbiota

    A unique set of skin microbiota for each individual Factors affecting the skin microbiota Functions of the microbiota and its interactions with the host

    Skin diseases associated with a dysbiosis

    Skin diseases associated with a dysbiosis Non-pathological skin conditions associated with a dysbiosis

    The gut-skin axis

    Psoriasis, atopic dermatitis, rosacea: gut-skin axis involved A gut-brain-skin axis?

    Modulating the skin microbiota

    Modulating the skin microbiota via topical applications Modulating the skin microbiota with oral solutions

    Expert opinion

    Dr. Markus Eger : Probiotics, a complementary therapeutic option
    Dermatology

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