Skip to main content
About the Institute
  • English
  • Français
  • Español
  • Russian

Breadcrumb

  1. Home
  2. Gut microbiota and immune defenses
  3. Pr. Patrice Debré
  • Our publications
    • News
    • Microbiota Mag
    • Thematic pages
    • Experts' point of view
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • About us
    • International Microbiota Observatory
    • Press room
    • Partnerships
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
  • Useful documents
    • How to talk about
    • Infographics
    • IBS Diagnosis Check List
    • Patients Stories

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube
    • Instagram
    • Bluesky

Lay public section

Find here your dedicated section
Gastroenterology
Gynecology
Pediatrics
General Medicine

Breadcrumb

  1. Home
  2. Gut microbiota and immune defenses
  3. Pr. Patrice Debré
Gastroenterology

Pr. Patrice Debré

Immunity
Gastroenterology

Patrice Debré is Professor Emeritus of Immunology at the Sorbonne University and member of the French National Academy of Medicine. He was Head of Immunology at the Hospital Pitié-Salpêtrière (AP-HP, Paris) and led research units at CNRS and Inserm. According to him, the study of the gut microbiota is key to better understand many non-transmissible human diseases, and especially those that involve the immune system.

Gastroenterology
Gynecology
Pediatrics
General Medicine
  • Our publications
    • News
    • Microbiota Mag
    • Thematic pages
    • Experts' point of view
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • About us
    • International Microbiota Observatory
    • Press room
    • Partnerships
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
  • Useful documents
    • How to talk about
    • Infographics
    • IBS Diagnosis Check List
    • Patients Stories

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube
    • Instagram
    • Bluesky

Lay public section

Find here your dedicated section

Sources

This article is based on scientific information

Sharing is caring

Your colleagues might be interested in this topic. Why not share it?

  • Facebook
  • Twitter
  • LinkedIn
  • Mail

Sections

About this article

Author

Défenses-immunitaires-expert-article-9 Prof. Patrice Debré
Created 30 September 2019
Updated 24 July 2024
Image
Patrice Debré

IMMUNE SYSTEM: TAKING INTO ACCOUNT THE GUT MICROBIOTA IS VITAL

What is the current state of research on the relations between immunity and gut microbiota?

Although the microbiota has been known since the days of Louis Pasteur, it was forgotten for a long time. However, it has been better understood in the past twenty years. Thanks to technical innovations (bacterial culture, metagenomics), bacteria from the gastrointestinal tract, which used to be poorly accessible, have been better characterized. We now have to refine our knowledge regarding their interactions with the body’s defense mechanisms, the way gut and other microbiotas are involved in the development of the immune system, which in turn has an impact on pathogen heterogeneity. The concept of “shaping” (or modulation of gut bacteria by the production of IgA in the gastrointestinal tract) is of foremost importance. This research approach is still poorly understood, but it should be critical in the years to come. Interactions between gut microbiota and immunity is a true shift in paradigm, and their results and study are not yet given their rightful place.

“Interactions between gut microbiota and immunity is a true shift in paradigm”

Do we know all the diseases associated with these relations?

There are many. Among those related to the immune system, in no hierarchical order, it is logical to mention autoimmune diseases and allergies, which are characterized by a breakdown of immune tolerance. Cancers are characterized by inflammatory processes and disruptions of the physiological balances between bacterial populations (dysbiosis). Less directly, regarding the role of the immune system, we should also mention obesity and metabolic disorders: bacteria-related inflammatory processes in the fatty tissue have been identified. Neuropsychiatric diseases could also be concerned: the intestinal production of serotonin that is transported to the brain through the vagus nerve should be further explored, but the link with immunity disorders is not obvious. Autism has also been mentioned: although the association with the gut microbiota is not crystal clear, it has already been suggested in several studies. Convincing mechanisms must be identified for the hypothesis to be confirmed.

Modulation of the gut microbiota: could it soon become a standard clinical practice?

One possibility could be to correct dysbioses or improve the gut flora with second-generation probiotics that are more targeted depending on the dysbiosis, compared to those from the first generation. Fecal microbiota transplants remain difficult because of the lack of standardization regarding protocol, sample collection or storage conditions. Modulation of the gut microbiota should rather be seen as an adjuvant: for instance, although the links between some bacterial populations and some types of cancer have been demonstrated, it would be unthinkable to manage without anticancer treatments. Standardized tests should be conducted to determine which populations should be grown and which should be destroyed. In a second phase, the efficacy of induced modifications should be confirmed and a durable colonization should be ensured. Before concluding anything, we should let research the time to progress.

Tags
Immunity Dysbiosis Gut health Microbiome Flora
    Focus
    Gut microbiota and immune defenses
    • Role of the gut microbiota in the development of the immune system
      • The gut microbiota, first bastion against aggressions
      • Role of the gut microbiota in immune regulation
    • Interactions and pathologies
      • Type I diabetes mellitus
      • Chronic inflammatory bowel diseases
      • Stem cell transplant and graft rejection
      • Respiratory infections
    • What is the potential role of microbiota modulation?
      • Preventing the risk of graft rejection
      • Stimulation of innate and adaptative immune responses
    • Expert interview
      • Pr. Patrice Debré
    Created 30 September 2019
    Updated 24 July 2024

    About this article

    To know more about this topic.

    Main topic

    Immunity

    Medical practice

    Gastroenterology

    Content type

    Expert opinion

    Author

    Défenses-immunitaires-expert-article-9 Prof. Patrice Debré
    Stimulation of innate and adaptative immune responses
    Focus

    Gut microbiota and immune defenses

    Role of the gut microbiota in the development of the immune system

    The gut microbiota, first bastion against aggressions Role of the gut microbiota in immune regulation

    Interactions and pathologies

    Type I diabetes mellitus Chronic inflammatory bowel diseases Stem cell transplant and graft rejection Respiratory infections

    What is the potential role of microbiota modulation?

    Preventing the risk of graft rejection Stimulation of innate and adaptative immune responses

    Expert interview

    Pr. Patrice Debré
    Gastroenterology
    Actu PRO : Malnutrition : agir sur le microbiote pour améliorer la croissance, un prototype à l’essai
    08.07.2021

    Malnutrition: acting on the microbiota in order to improve growth, a trial prototype

    Read the article
    07.05.2025

    The microbial-metabolic nexus in colon cancer

    Read the article
    07.02.2025

    Your functional dyspepsia diagnosis check list

    Read the article
    17.04.2025

    Sensitivity to the additive E466: the role of the microbiota

    Read the article
    Photo HCPs: Clinical context over quick fix: the fresh consensus on microbiome testing
    11.04.2025

    Clinical context over quick fix: the fresh consensus on microbiome testing

    Read the article
    22.11.2023

    Is vaginal microbiota transfer the new miracle for C-section babies?

    Read the article
    Actu PRO : Alcoolisme : expliquer les troubles sociaux grâce au microbiote
    27.01.2021

    Alcoholism: explaining social disorders thanks to the microbiota

    Read the article

    Association between fungal dysbiosis and environment

    The fungal portion of the gut microbiota (or mycobiota) has been much less studied than the bacterial...

    Find out more
    • Our publications
      • News
      • Microbiota Mag
      • Thematic pages
      • Experts' point of view
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • About us
      • International Microbiota Observatory
      • Press room
      • Partnerships
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
    • Useful documents
      • How to talk about
      • Infographics
      • IBS Diagnosis Check List
      • Patients Stories

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube
      • Instagram
      • Bluesky

    Lay public section

    Find here your dedicated section
    Gastroenterology
    Gynecology
    Pediatrics
    General Medicine
    • English
    • Français
    • Español
    • Russian

    Browse the site

    • Our publications
      • News
      • Microbiota Mag
      • Thematic pages
      • Experts' point of view
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • About us
      • International Microbiota Observatory
      • Press room
      • Partnerships
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
    • Useful documents
      • How to talk about
      • Infographics
      • IBS Diagnosis Check List
      • Patients Stories

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube
      • Instagram
      • Bluesky

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    General Medicine

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube
    • Instagram
    • Bluesky

    Lay public section

    Find here your dedicated section

    Redirection

    You are about to be redirected and leave our website

    • Be redirected
    • Stay on the Biocodex Microbiota Institute's website

    Stay with us !

    Join the Microbiota Community of HCPs and researchers and receive “Microbiota Digest” and "Microbiota Mag" to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    Explore

    14.05.2025

    Towards worldwide redefinition of healthy vaginal microbiota

    Read the article
    07.05.2025

    The microbial-metabolic nexus in colon cancer

    Read the article
    02.05.2025

    A new lens on chlamydia: beyond behavior, into the microbiome

    Read the article

    Stay updated

    Join the Microbiota Community of HCPs and researchers and receive “Microbiota Digest” and "Microbiota Mag" to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    • Our publications
      • News
      • Microbiota Mag
      • Thematic pages
      • Experts' point of view
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • About us
      • International Microbiota Observatory
      • Press room
      • Partnerships
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
    • Useful documents
      • How to talk about
      • Infographics
      • IBS Diagnosis Check List
      • Patients Stories

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube
      • Instagram
      • Bluesky

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    General Medicine

    Lay public section

    Find here your dedicated section

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube
    • Instagram
    • Bluesky

    © 2025 Biocodex. All rights reserved.

    • Legal notice
    • GTU
    • Data protection policy
    • Sitemap
    • Cookies settings
    • Digital accessibility : partially compliant
    Biocodex logo