Skip to main content
About the Institute
  • English
  • Français
  • Español
  • Russian
  • Portuguese

Breadcrumb

  1. Home
  2. Gynecology
  3. Vaginal microbiota: a marker for papillomavirus progression?
  • Our publications
    • News
    • Microbiota Mag
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • Partnerships
    • Press room
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
    • Xpeer App
  • Useful documents
    • Infographics
    About the Institute

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

Lay public section

Find here your dedicated section
Gastroenterology
Gynecology
Pediatrics
Dermatology

Breadcrumb

  1. Home
  2. Gynecology
  3. Vaginal microbiota: a marker for papillomavirus progression?
Gynecology

Vaginal microbiota: a marker for papillomavirus progression?

Vaginal condition
Gynecology

The presence of Gardnerella in the cervicovaginal microbiota of women with high-risk oncogenic papillomavirus may indicate an increase in microbial diversity and predict progression towards precancerous lesions.

Gastroenterology
Gynecology
Pediatrics
Dermatology
  • Our publications
    • News
    • Microbiota Mag
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • Partnerships
    • Press room
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
    • Xpeer App
  • Useful documents
    • Infographics
    About the Institute

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

Lay public section

Find here your dedicated section

Sources

This article is based on scientific information

Sharing is caring

Your colleagues might be interested in this topic. Why not share it?

  • Facebook
  • Twitter
  • LinkedIn
  • Mail
Photo : Vaginal microbiota: a marker for papillomavirus progression?

About this article

Created 02 June 2020
Updated 06 October 2021

The human papillomavirus (HPV) is the most common sexually transmitted infectious agent. While for most women HPV clears up quickly, a small fraction develops persistent infection with a high risk of progression towards precancerous lesions and cervical cancer. Certain environmental (smoking, hormonal contraception) and clinical (genetics, immune system, parity) factors have been linked to the progression or elimination of HPV. The cervicovaginal microbiota (CVM) has been shown to be involved in the prevalence of the disease but its influence on whether HPV is eliminated or progresses towards moderate to severe dysplasia ( (sidenote: Cervical intraepithelial neoplasia (CIN). CIN2+ involves Grade II precancerous lesions or moderate dysplasia, while CIN3+ entails high-grade precancerous lesions or severe dysplasia ) ) is not yet known.

Lactobacillus iners: a sign of HPV clearance

Taking advantage of a clinical trial in Costa Rica evaluating an HPV vaccine, researchers1 analyzed the microbial composition of cervical samples from the study’s placebo group. They studied the microbiota of 273 women with high-risk oncogenic HPV (HR-HPV) and assessed the changes one year later. At the first visit (V1), virus clearance was correlated with the presence of L. iners. On the other hand, progression of the disease was correlated with the presence of Gardnerella at V1 and with that of a polymicrobial vaginal community at the second visit (V2).

Gardnerella: a key role in the progression of HPV

The researchers then modelled the course of the disease by combining clinical features (age, smoking, virus genotype, etc.) with data on the structure of the CVM obtained at V1 and V2. Their bioinformatics analysis suggests that Gardnerella is involved in the development of precancerous lesions. However, instead of a direct role, Gardnerella is thought to induce an increase in bacterial diversity which in turn leads to the progression of infection towards precancerous lesions.

A strategy to prevent HPV progression?

A separate team had published similar results a few weeks earlier2. Both studies hypothesize that a vaginal dysbiosis may facilitate the progression of oncogenic HPV towards precancerous lesions. They also point out that the CVM contains biomarkers which help identify patients at risk. If future studies confirm a central role for the CVM in the evolution of HPV infection, therapeutic strategies to prevent the progression of the disease based on modulating the CVM could be contemplated.

 

Sources

1. Usyk M, Zolnik CP, Castle PE, et al. Cervicovaginal microbiome and natural history of HPV in a longitudinal study. PLoS Pathog. 2020;16(3):e1008376. 

2. Chao X, Sun T, Wang S, et al. Research of the potential biomarkers in vaginal microbiome for persistent high-risk human papillomavirus infection. Ann Transl Med. 2020;8(4):100. 

Tags
Candidiasis Dysbiosis Papillomavirus Cancer Vagina Virus

en_view en_sources

    Created 02 June 2020
    Updated 06 October 2021

    About this article

    To know more about this topic.

    Main topic

    Vaginal condition

    Medical practice

    Gynecology

    Content type

    News
    Gynecology

    From diarrhea to chronic diseases: the well-documented consequences of antibiotic-related gut microbiota dysbiosis

    Antibiotic treatment may sometimes take place without any...

    Find out more

    Vaginal Microbiota # 16

    By Pr. Satu PekkalaAcademy of Finland Research Fellow, Faculty of Sport and Health Sciences, University of ...

    Find out more

    Vaginal microbiota # 14

    By Pr. Markku VoutilainenTurku University Faculty of Medicine; Turku University Hospital, Department of Gas...

    Find out more

    Vaginal Microbiota #15

    By Pr. Markku VoutilainenTurku University Faculty of Medicine; Turku University Hospital, Department of Gas...

    Find out more

    Urinary tract infections

    Infections of the lower urogenital tract are extremely common amongst women: seven out of ten women will su...

    Find out more

    Vaginal microbiota #10

    By Pr. Markku VoutilainenTurku University Faculty of Medicine; Turku University Hospital, Department of Gas...

    Find out more

    Targeting the gut microbiota to optimize vaccine efficacy?

    by Dr Genelle Healey

    Find out more

    The hygiene hypothesis and the COVID-19 pandemic

    by Dr Genelle Healey

    Find out more

    Continue reading

    News
    Cancer du col de l’utérus : l’étau se resserre sur L. iners
    14.02.2023

    Cervical cancer: the walls are closing in on L. iners

    Read the article
    Pregnancy: is vaginal dysbiosis responsible for complications in case of COVID-19?
    06.01.2023

    Pregnancy: is vaginal dysbiosis responsible for complications in case of COVID-19?

    Read the article
    Photo: WAAW 2022 (HCPs)
    25.10.2022

    Microbiota at the forefront of antibiotic resistance

    Read the article
    25.10.2022

    Antibiotics: Dr Jekyll and Mr Hyde

    Read the article
    Everything you need to know about Microbiota & Dysbiosis
    27.07.2022

    Everything you need to know about Dysbiosis

    Read the article
    Photo: Antibiotic resistance is a web of several problems (HCPs)
    02.11.2022

    Antibiotic resistance is a web of several problems

    Read the article
    Actu PRO : Une antibiothérapie prophylactique péri-partum appauvrit le lait maternel en Bifidobacterium
    12.03.2019

    Peripartum prophylactic antibiotic therapy decreases bifidobacterium levels in breast milk

    Read the article
    28.10.2021

    6 things you should know about antibiotics

    Read the article
    What's worth reading about microbiota
    Follow us on Twitter
    Read our thematic folder
    The Janus face of Antibiotics: Life Savers & Microbiota Disrupters
    NL13_cover
    Check out latest newsletter
    IBS, Microbiota & Covid-19
    • Our publications
      • News
      • Microbiota Mag
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographics
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube

    Lay public section

    Find here your dedicated section
    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology
    • English
    • Français
    • Español
    • Russian
    • Portuguese

    Browse the site

    • Our publications
      • News
      • Microbiota Mag
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographics
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

    Lay public section

    Find here your dedicated section

    Redirection

    You are about to be redirected and leave our website

    • Be redirected
    • Stay on the Biocodex Microbiota Institute's website

    Stay with us !

    Join the Microbiota Community of HCPs and researchers and receive “Microbiota Digest” and "Microbiota Mag" to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    Explore

    L’axe intestin-cerveau dans le stress lié à la discrimination
    20.03.2023

    The gut-brain axis and discrimination-related stress

    Read the article
    20.03.2023

    The role of Bifidobacteria in irritable bowel syndrome (IBS)

    Read the article
    14.03.2023

    Positive impact of running on gut microbiota and adolescent depression

    Read the article

    Stay updated

    Join the Microbiota Community of HCPs and researchers and receive “Microbiota Digest” and "Microbiota Mag" to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    • Our publications
      • News
      • Microbiota Mag
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • Partnerships
      • Press room
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
      • Xpeer App
    • Useful documents
      • Infographics
      About the Institute

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    Dermatology

    Lay public section

    Find here your dedicated section

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube

    © 2022 Biocodex. All rights reserved.

    • Cookies Policy
    • Data protection policy
    • GTU
    • Sitemap
    • Cookies settings
    Biocodex logo