Gastroenterology

What to take away? Intestinal Immunity

Immunity

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Created 24 November 2021
Updated 25 November 2021

The microbiota plays critical roles in the development and education of the host’s innate and adaptive immune system components, while the immune system orchestrates the maintenance of key features of host-microbe symbiosis. Maintaining homeostasis between the gut microbiota and the immune system is essential, determinants interfering with neonatal gut establishment (antibiotics...) may potentially lead to negative health outcomes.1

80% At least 80% of the body Ig-producing cells are located in the gut (2)

MUCUS

The intestinal mucus layer is at the crucial interface between host and gut microbiota. Its disruption leads increased penetration or passage of potentially harmful bacteria that can eventually cause inflammation and infection.3

Sources

1 Robertson RC, Manges AR, Finlay BB, et al. The Human Microbiome and Child Growth - First 1000 Days and Beyond. Trends Microbiol. 2019 Feb;27(2):131-147. 

2 Brandtzaeg P. (2017) Role of the Intestinal Immune System in Health. In: Baumgart D. (eds) Crohn's Disease and Ulcerative Colitis. Springer, Cham. 

3 Johansson ME, Gustafsson JK, Holmén-Larsson J, et al. Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis. Gut. 2014 Feb;63(2):281-91.

Tags
Immunity Gut microbiota Dysbiosis Antibiotics Diversity Mucus

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    Focus

    Microbiota, a diplomatic immunity?

    Introduction

    Understanding the complex interplay between the microbiota and immunity is only just beginning

    Intestinal Immunity

    The infant's gut at the heart of immunity Factors influencing microbiota development and maturation of the immune system early in life The impact of western diet on the mucus layer Dampening gastrointestinal inflammation through nutrition

    Gut microbiota influences respiratory immunity

    The gut microbiota is involved in the lung’s defense against viral respiratory infections Gut-lung axis in viral respiratory infections The hygiene hypothesis and the COVID-19 pandemic Targeting the gut microbiota to optimize vaccine efficacy?

    Role of the microbiota in skin immunity and atopic dermatitis

    Expert interview: Pr. Brigitte Dréno

    Conclusion

    What to take away? Intestinal Immunity What to take away? Respiratory immunity What to take away? Skin immunity

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