What to take away? Intestinal Immunity
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The microbiota plays critical roles in the development and education of the host’s innate and adaptive immune system components, while the immune system orchestrates the maintenance of key features of host-microbe symbiosis. Maintaining homeostasis between the gut microbiota and the immune system is essential, determinants interfering with neonatal gut establishment (antibiotics...) may potentially lead to negative health outcomes.1
80% At least 80% of the body Ig-producing cells are located in the gut (2)
2 Brandtzaeg P. (2017) Role of the Intestinal Immune System in Health. In: Baumgart D. (eds) Crohn's Disease and Ulcerative Colitis. Springer, Cham.
3 Johansson ME, Gustafsson JK, Holmén-Larsson J, et al. Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis. Gut. 2014 Feb;63(2):281-91.