Gastroenterology

What to take away? Respiratory immunity

Immunity

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Created 24 November 2021
Updated 25 November 2021

The bidirectional communication axis between the gut and lungs, called the “gut–lung axis” influences the immune status of both organs.

Lung and gut microbiota influence each other and may have an impact on respiratory diseases.4

1 1 factor known to control vaccine efficacy can be gut microbiota.(5)

DYSBIOSIS

Lung and gut dysbiosis are observed during viral respiratory infections.6 Common definition of dysbiosis describes it as a compositional and functional alteration in the microbiota that is driven by a set of environmental and host-related factors that perturb the microbial ecosystem.7

Sources

4 Sencio V, Machado MG, Trottein F. The lung-gut axis during viral respiratory infections: the impact of gut dysbiosis on secondary disease outcomes. Mucosal Immunol. 2021 Mar;14(2):296-304.

5 Lynn DJ, Benson SC, Lynn MA, et al. Modulation of immune responses to vaccination by the microbiota: implications and potential mechanisms. Nat Rev Immunol. 2021 May 17:1–14. 

6 Dumas A, Bernard L, Poquet Y, et al. The role of the lung microbiota and the gut-lung axis in respiratory infectious diseases. Cell Microbiol. 2018 Dec;20(12):e12966. 

7 Levy M, Kolodziejczyk AA, Thaiss CA, et al. Dysbiosis and the immune system. Nat Rev Immunol. 2017;17(4):219-232.

Tags
Immunity Gut microbiota gut-lung axis Dysbiosis Lungs Respiratory infections Winter lung infection Virus Viral Coronavirus SARS-CoV-2

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    Focus

    Microbiota, a diplomatic immunity?

    Introduction

    Understanding the complex interplay between the microbiota and immunity is only just beginning

    Intestinal Immunity

    The infant's gut at the heart of immunity Factors influencing microbiota development and maturation of the immune system early in life The impact of western diet on the mucus layer Dampening gastrointestinal inflammation through nutrition

    Gut microbiota influences respiratory immunity

    The gut microbiota is involved in the lung’s defense against viral respiratory infections Gut-lung axis in viral respiratory infections The hygiene hypothesis and the COVID-19 pandemic Targeting the gut microbiota to optimize vaccine efficacy?

    Role of the microbiota in skin immunity and atopic dermatitis

    Expert interview: Pr. Brigitte Dréno

    Conclusion

    What to take away? Intestinal Immunity What to take away? Respiratory immunity What to take away? Skin immunity

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