Skip to main content
About the Institute
  • English
  • Français
  • Español
  • Russian
  • Portuguese
  • Polish

Breadcrumb

  1. Home
  2. Gynecology
  3. Postmenopause: the beneficial action of estradiol on the vaginal microbiota
  • Our publications
    • News
    • Microbiota Mag
    • Thematic pages
    • Experts' point of view
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • About us
    • International Microbiota Observatory
    • Press room
    • Partnerships
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
  • Useful documents
    • How to talk about
    • Infographics
    • IBS Diagnosis Check List
    • Patients Stories

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube
    • Instagram
    • Bluesky

Lay public section

Find here your dedicated section
Gastroenterology
Gynecology
Pediatrics
General Medicine

Breadcrumb

  1. Home
  2. Gynecology
  3. Postmenopause: the beneficial action of estradiol on the vaginal microbiota
Gynecology

Postmenopause: the beneficial action of estradiol on the vaginal microbiota

Menopause

Treating genitourinary symptoms of the menopause with vaginal estradiol appears to positively modify the vaginal microenvironment. Estradiol may have beneficial effects on the microbiota that are much more effective than simply treating symptoms.

Gastroenterology
Gynecology
Pediatrics
General Medicine
  • Our publications
    • News
    • Microbiota Mag
    • Thematic pages
    • Experts' point of view
    • Thematic folders
    • Overviews - Microbiota Magazine
  • About the Institute
    • About us
    • International Microbiota Observatory
    • Press room
    • Partnerships
  • Congresses
    • Congress calendar
    • Congress reviews
  • Continuing Medical Education
    • Accrediting courses
  • Useful documents
    • How to talk about
    • Infographics
    • IBS Diagnosis Check List
    • Patients Stories

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube
    • Instagram
    • Bluesky

Lay public section

Find here your dedicated section

Sources

This article is based on scientific information

Sharing is caring

Your colleagues might be interested in this topic. Why not share it?

  • Facebook
  • Twitter
  • LinkedIn
  • Mail
Photo: Postménopause : l'action bénéfique de l'estradiol sur le microbiote vaginal

About this article

Created 22 June 2022
Updated 25 March 2024

29% Only 1 in 4 women aged 60 and over said their doctor had ever taught them what vaginal microbiota was and what it was used for (vs. 35% overall)

Learn more:
What women know (and don't know) about their vaginal microbiota

Vaginal dryness, pain, itching: postmenopause often comes with genitourinary symptoms. Vaginal estradiol or a moisturizing cream are frequently prescribed to relieve these symptoms, but the impact of these treatments on the vaginal microenvironment is poorly understood.

A comparative study

In 2016-2017, 302 postmenopausal women (average age 64) with moderate to severe vulvovaginal discomfort took part in the MsFLASH Vaginal Health Trial, a multicenter double-blind randomized clinical trial.

The aim :

The aim was to compare at 12 weeks the effect of a 0.01 mg vaginal estradiol tablet (+ a placebo gel) and a vaginal moisturizing gel (+ a placebo tablet) with a double placebo. While there was surprisingly no major difference in the reduction of symptoms experienced, at 12 weeks, more participants in the estrogen group had a vaginal pH of less than 5 and more than 5% superficial cells on VMI (Vaginal Maturation Index) than the placebo group.

Should these changes be interpreted as a beneficial effect on the vaginal environment beyond the mere improvement of symptoms? This is what the researchers sought to find out via a post-hoc analysis of a sub-group of 144 postmenopausal women.

Towards a healthier vaginal microbiota?

At 12 weeks, 80% of women in the estradiol group had vaginal bacterial communities dominated by Lactobacillus and Bifidobacterium, compared to only 36% in the moisturizer group and 26% in the placebo group.
Another change observed in the estradiol group was a change in the composition of vaginal fluid metabolites (significant changes for more than half of the 171 metabolites tested), including an increase in lactate, most certainly contributing to the additional decrease in pH in this group.
The effect of estradiol was more pronounced in women who initially had a very diverse vaginal microbiota (considered less healthy), a high vaginal pH, and a low VMI. Estradiol may therefore stimulate the metabolic activity of beneficial lactic acid-producing bacteria, such as lactobacilli and bifidobacteria.

Multiple findings

  • The use of vaginal estradiol tablets appears to result in profound changes to the vaginal microbiota and metabolome.
  • The benefits of the low pH moisturizer and the double placebo (lubricating effect) are limited to symptoms only.They show no significant impact on the vaginal microbiota or metabolome, despite the decrease in vaginal pH they bring about. 
  • This study shows that an identical reduction in pH following two different types of treatment does not necessarily reflect the same underlying biological effect, and that reducing the vaginal pH is not enough to modify the vaginal microbiota in postmenopausal women. According to the authors, this puts the value of pH-balanced gels into perspective.
Sources

Srinivasan S, Hua X, Wu MC et al. Impact of Topical Interventions on the Vaginal Microbiota and Metabolome in Postmenopausal Women: A Secondary Analysis of a Randomized Clinical Trial. JAMA Netw Open. 2022 Mar 1;5(3):e225032.

Tags
Menopause Women health Oestradiol Microbiome Flora

    See also

    Actu PRO : Microbiote urinaire des femmes continentes : l’effet de l’âge Urinary microbiota in continent women: the effect of age
    Dysbiosis-related infections of the lower genital tract
    Created 22 June 2022
    Updated 25 March 2024

    About this article

    To know more about this topic.

    Main topic

    Menopause

    Content type

    News
    Gynecology

    Dysbiosis-related infections of the lower genital tract

    Unlike the urinary microbiota and many other microbiotas, the vaginal microbiota, when healthy, has l...

    Find out more

    Urinary area: efficacy to be confirmed in clinical trials

    Since lower urogenital infections seem closely related to a dysbiosis of the urinary or vaginal micro...

    Find out more

    Urinary tract infections

    Infections of the lower urogenital tract are extremely common amongst women: seven out of ten women w...

    Find out more

    Dysbiosis-related urinary tract infections

    The microbiota seems to play an important role in infections of the lower urogenital system, whether ...

    Find out more

    The infant's gut at the heart of immunity

    By Dr Travis J. De Wolfe

    Find out more

    Factors influencing microbiota development and maturation of the immune system early in life

    Birth represents the biggest substantial environmen...

    Find out more

    From diarrhea to chronic diseases: the well-documented consequences of antibiotic-related gut microbiota dysbiosis

    Antibiotic treatment may sometimes take place witho...

    Find out more

    Urogenital microbiota: the spectrum of mycosis or urinary tract infections after each antibiotic treatment

    A vicious circle. Vaginal tract infections such as ...

    Find out more

    Continue reading

    News
    14.05.2025

    Towards worldwide redefinition of healthy vaginal microbiota

    Read the article
    02.05.2025

    A new lens on chlamydia: beyond behavior, into the microbiome

    Read the article
    02.04.2025

    A type of vaginal dysbiosis for each type of infertility?

    Read the article
    13.02.2025

    How do I deal with menopause?

    Read the article
    13.02.2025

    “I'm 45, why do I have all these symptoms now (hot flashes, insomnia, dryness, swollen belly)? Is it menopause?”

    Read the article
    13.02.2025

    Will having too much sex affect my pH, or give me vaginitis or thrush? Or will it give me a STI?

    Read the article
    13.02.2025

    "Help, I don't want to have sex anymore: I'm too tired, stressed, I don't feel sexy, what is wrong with me?"

    Read the article
    13.02.2025

    Why is it itching down there?

    Read the article
    • Our publications
      • News
      • Microbiota Mag
      • Thematic pages
      • Experts' point of view
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • About us
      • International Microbiota Observatory
      • Press room
      • Partnerships
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
    • Useful documents
      • How to talk about
      • Infographics
      • IBS Diagnosis Check List
      • Patients Stories

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube
      • Instagram
      • Bluesky

    Lay public section

    Find here your dedicated section
    Gastroenterology
    Gynecology
    Pediatrics
    General Medicine
    • English
    • Français
    • Español
    • Russian
    • Portuguese
    • Polish

    Browse the site

    • Our publications
      • News
      • Microbiota Mag
      • Thematic pages
      • Experts' point of view
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • About us
      • International Microbiota Observatory
      • Press room
      • Partnerships
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
    • Useful documents
      • How to talk about
      • Infographics
      • IBS Diagnosis Check List
      • Patients Stories

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube
      • Instagram
      • Bluesky

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    General Medicine

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube
    • Instagram
    • Bluesky

    Lay public section

    Find here your dedicated section

    Redirection

    You are about to be redirected and leave our website

    • Be redirected
    • Stay on the Biocodex Microbiota Institute's website

    Stay with us !

    Join the Microbiota Community of HCPs and researchers and receive “Microbiota Digest” and "Microbiota Mag" to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    Explore

    14.05.2025

    Towards worldwide redefinition of healthy vaginal microbiota

    Read the article
    07.05.2025

    The microbial-metabolic nexus in colon cancer

    Read the article
    02.05.2025

    A new lens on chlamydia: beyond behavior, into the microbiome

    Read the article

    Stay updated

    Join the Microbiota Community of HCPs and researchers and receive “Microbiota Digest” and "Microbiota Mag" to stay up to date on the latest news about microbiota.

    * Mandatory Fields

    BMI 20-35

    • Our publications
      • News
      • Microbiota Mag
      • Thematic pages
      • Experts' point of view
      • Thematic folders
      • Overviews - Microbiota Magazine
    • About the Institute
      • About us
      • International Microbiota Observatory
      • Press room
      • Partnerships
    • Congresses
      • Congress calendar
      • Congress reviews
    • Continuing Medical Education
      • Accrediting courses
    • Useful documents
      • How to talk about
      • Infographics
      • IBS Diagnosis Check List
      • Patients Stories

      Join the microbiota community

      • Facebook
      • Twitter
      • LinkedIn
      • YouTube
      • Instagram
      • Bluesky

    Lay public section

    Find here your dedicated section

    Discover

    Gastroenterology
    Gynecology
    Pediatrics
    General Medicine

    Lay public section

    Find here your dedicated section

    Join the microbiota community

    • Facebook
    • Twitter
    • LinkedIn
    • YouTube
    • Instagram
    • Bluesky

    © 2025 Biocodex. All rights reserved.

    • Legal notice
    • GTU
    • Data protection policy
    • Sitemap
    • Cookies settings
    • Digital accessibility : partially compliant
    Biocodex logo